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In Person Seminar: A Novel Metabolic-Epigenetic Axis in Vascular Remodeling Processes

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Sébastien Bonnet, Ph.D.

Department of Medicine
Director, Canadian Research Chair in Translational Research in Pulmonary and Vascular Diseases
University of Laval

Pioneers in Biomedical Research Seminar: A Novel Metabolic-Epigenetic Axis in Vascular Remodeling Processes


Date: Feb. 3, 2023

Time: 11 a.m. - 12 p.m.

Location: Fralin Biomedical Research Institute at VTC, Room G101A/B, 4 Riverside Circle, Roanoke, Virginia

Virtual attendance:  Join via Zoom.

About this Seminar

Vascular remodeling is a common feature to many vascular diseases including coronary artery diseases (CAD) and pulmonary arterial hypertension (PAH). Although current therapies improve outcomes in patients, both diseases remain deadly. Developing novel treatment aimed to decrease the excess of cell proliferation causing vascular remodeling is thus critical. Dr. Bonnet and his lab identified the enzyme ATP-citrate lyase (ACLY) as novel signaling hub controlling both metabolism and epigenetic reprogramming of vascular cells implicated in vascular lesions. Blocking ACLY showed interesting therapeutic effects in both CAD and PAH.

Additional Details

This is a free event hosted by the Fralin Biomedical Research Institute and co-sponsored by the institute's Center for Vascular and Heart Research. The Pioneers in Biomedical Research Seminar Series, which runs annually from September to May, has featured leading biomedical researchers from throughout the country since the program began in 2012. The lectures are also open to all members of the Virginia Tech community including graduate students, undergraduates, faculty, and staff, as well as the public.

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