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Inter-Organelle Communication Pathways and Dynamics Revealed by Imaging

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Jennifer Lippincott-Schwartz, Ph.D.

Senior Group Leader
Interim Head of 4D Cellular Physiology
Howard Hughes Medical Institute, Janelia Research Campus

Pioneers in Biomedical Research Seminar: Inter-Organelle Communication Pathways and Dynamics Revealed by Imaging

Date: Sept. 9, 2022

Time: 11 a.m. - 12 p.m.

Location: Fralin Biomedical Research Institute at VTC, Room G101A/B, 4 Riverside Circle, Roanoke, Virginia

Virtual attendance:  Join via Zoom.

About this Seminar

Powerful new ways to image the internal structures and complex dynamics of cells are revolutionizing cell biology and bio-medical research. In this talk, Dr. Lippincott-Schwartz will focus on how emerging fluorescent technologies are increasing spatio-temporal resolution dramatically, permitting simultaneous multispectral imaging of multiple cellular components. In addition, results will be discussed from whole cell milling using Focused Ion Beam Electron Microscopy (FIB-SEM), which reconstructs the entire cell volume at 4 voxel resolution. Using these tools, it is now possible to begin constructing an “organelle interactome”, describing the interrelationships of different cellular organelles as they carry out critical functions. The same tools are also revealing new properties of organelles and their trafficking pathways, and how disruptions of their normal functions due to genetic mutations may contribute to important diseases.

Additional Details

This is a free event hosted by the Fralin Biomedical Research Institute and co-sponsored by the institute's Center for Neurobiology Research. The Pioneers in Biomedical Research Seminar Series, which runs annually from September to May, has featured leading biomedical researchers from throughout the country since the program began in 2012. The lectures are also open to all members of the Virginia Tech community including graduate students, undergraduates, faculty, and staff, as well as the public.

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