Kevin Pridham, Ph.D.
- Gourdie Lab
Dr. Pridham's research primarily focuses on Glioblastoma Multiforme (GBM). GBM is a lethal and incurable brain cancer as it often recurs after conventional treatments. His research focuses on combating drug resistance in Glioblastoma (GBM), developing therapeutics to treat GBM, and implementing novel methods to deliver drugs to the brain to treat GBM.
For a more complete list of publications, visit the following publication sites: PubMed
Sheng KL, Pridham KJ, Sheng Z, Lamouille S, and Varghese RT. Functional blockade of the small GTPase RAN inhibits glioblastoma viability. Frontiers in Oncology. Frontiers in Oncology. 2019 Jan 8;8:662. PMID: 30671385.
Liang Y, Dearnaley WJ, Alden NA, Solares MJ, Gilmore BL, Pridham KJ, Varano AC, Sheng Z, Alli E, Kelly DF. Correcting errors in the BRCA1 warning system. DNA Repair. 2019 Jan;73:120-128. PMID: 30503669.
Varghese RT, Young S, Pham LC, Liang Y, Pridham KJ, Guo S, Murphy SF, Kelly DF, and Sheng Z. Casein kinase 1 epsilon regulates glioblastoma cell survival. Scientific Reports. 2018 Sep 11;8(1):13621. PMID: 30206363.
Pridham KJ, Le L, Guo S, Varghese RT, Algino S, Liang Y, Fajardin R, Rodgers CM, Simonds GR, Kelly DF, and Sheng Z. PIK3CB/p110β is a selective survival factor for glioblastoma. Neuro-Oncology. 2018 Mar 27;20(4):494-505. PMID: 29016844.
Guo S, Pridham KJ, Virbasius CM, Hee B, Zhang L, Varmark H, Green MR, and Sheng Z. A large-scale RNA interference screen identifies genes that regulate autophagy at different stages. Scientific Reports. 2018 Feb 12;8(1):2822. PMID: 29434216.
Pridham KJ, Varghese RT, and Sheng Z. The role of class IA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunits in glioblastoma. Frontiers in Oncology. 2017 Dec 15;7:312. PMID: 29326882.
Guo S, Pridham KJ, and Sheng Z. Detecting autophagy and autophagy flux in chronic myeloid leukemia cells using a cyto-ID fluorescence spectrophotometric assay. Methods in Molecular Biology. 2016 Sep 2;(1465):95-109. PMID: 27581142.
Brzeska H, Koech H, Pridham KJ, and Korn ED. Selective localization of myosin-I proteins in macropinosomes and actin waves. Cytoskeleton. 2016 Feb 7;73(2):68-82. PMID: 26801966.
Murphy SF, Varghese RT, Lamouille S, Guo S, Pridham KJ, Kanabur P, Osimani AM, Sharma S, Jourdan J, Rodgers CM, Simonds GR, Gourdie RG, and Sheng Z. Connexin 43 inhibition sensitizes chemoresistant glioblastoma cells to temozolomide. Cancer Research. 2016 Jan 1;76(1):139-149. PMID: 26542214.
Brzeska H, Pridham KJ, Chery G, Titus MA, and Korn ED. The association of myosin IB with actin waves in dictyostelium requires both the plasma membrane-binding site and actin-binding region in the myosin tail. PLoS One. 2014 Apr 18;9(4):e94306. PMID: 24747353.
Cherkasova V, Maury LL, Bacikova D, Pridham KJ, Bahler J, and Maraia RJ. Altered nuclear tRNA metabolism in La-deleted Schizosaccharomyces pombe is accompanied by a nutritional stress response involving Atf1p and Pcr1p that is suppresible by Xpo-t/Los1p. Molecular Biology of the Cell. 2012 Feb 23;(3):480-491. PMID: 22160596.
- Ph.D., Translational Biology, Medicine, and Health, Virginia Tech
- B.S., Biochemistry, Loyola University Maryland
- VTCRI research team identifies a potential strategy in fight against brain cancer
- First students earn degrees through innovative translational biology, medicine, and health program
- VTCRI scientists identify new target for developing precision treatment in malignant brain tumors
- TBMH students contribute to brain cancer research finding
- Researchers find way to make resistant brain cancer cells sensitive to treatment
THE GOURDIE LAB