Hodja Kalikulov, Ph.D.
- Friedlander Lab
Synaptic plasticity is widely considered to be a cellular mechanism underlying learning and memory. Intracellular calcium signaling plays a key role in the regulation of synaptic plasticity in many brains system. We previously showed that pairing of pre- and postsynaptic activity in layer 2/3 pyramidal neurons in visual cortex at a fixed temporal delay produces variable plasticity outcomes - long-term potentiation (LTP), long-term depression (LTD), or no change (NC) - in different cells. The major goal of my research is to determine whether these different plasticity outcomes are a function of the individual cell’s intracellular calcium signaling in response to the pairings.
Zhu PJ, Huang W, Kalikulov D, Yoo JW, Placzek AN, Stoica L, Zhou H, Bell JC, Friedlander MJ, Krnjević K, Noebels JL, Costa-Mattioli M. (2011). Suppression of PKR Promotes Network Excitability and Enhanced Cognition by Interferon-γ-Mediated Disinhibition. Cell 147(6): 1384-96.
Ismailov I, Kalikulov D, Inoue T, Friedlander MJ. (2004). The kinetic profile of intracellular calcium predicts long-term potentiation and long-term depression. J Neurosci 24(44): 9847-61.
Kalikulov D, Ayar A, Nuritova F, Frenguelli BG, McClelland Martin DJ, Davidson I, Scott RH. (2001). Venom from Anemesia species of spider modulates high voltage-activated Ca2+ currents from rat cultured sensory neurones and excitatory postsynaptic currents from rat hippocampal slices. Cell Calcium 30(3): 212-21.
- Institute of Biochemistry, Academy of Sciences of Uzbekistan: Ph.D., Biophysics
- Baylor College of Medicine: Postdoctoral Fellowship, Neuroscience
THE FRIEDLANDER LAB