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Human brain organoid

Oct. 20, 2026

Iron deficiency may explain psychiatric outcomes of a rare genetic condition

The image on Ryan Purcell’s monitor shows what looks like yellow sunbursts among threads of magenta and green. It’s a research image of a microscopic cluster of human neurons reaching for one another across the dark of a petri dish.

Together, this cluster of cells is called a brain organoid, and Purcell, an assistant professor at the Fralin Biomedical Research Institute at VTC, uses them to study a question that brought him to the institute: Why do some people born with a rare genetic deletion develop serious psychiatric disorders, while others with the same variant do not?

With the support of a research grant from the National Institute of Mental Health, Purcell is working to understand why 3q29 deletion syndrome can result in vastly different outcomes between individuals.

He suspects it may have something to do with iron.

 

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The Fralin Biomedical Research Institute at VTC is one of the nation’s fastest-growing academic biomedical research enterprises and a destination for world-class biomedical, behavioral, and computational researchers focused on advancing scientific understanding of human health through groundbreaking research in preventing, diagnosing, and treating the world’s leading causes of death and suffering.


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Giving to the Research Institute

Your generous support of the Fralin Biomedical Research Institute's rigorous biomedical research enterprise makes a difference for our faculty, students, and patients. Every donation helps accelerate the pace of new discoveries to help patients with cancer, neurological disorders, heart disease, and even rare genetic disorders. Private donations fast-track our progress.