Dr. Van der Heijden's Publications
View Dr. Van der Heijden publications on Google Scholar
* = Equal contributions; ^ = Corresponding author
Van der Heijden, ME*^, Brown, AM*, Kizek, DJ, Sillitoe, RV^. (2023) Neural spike signatures determine the behavioral presentation of cerebellar disease. Preprint on: bioRxiv. DOI:10.1101/2023.05.07.539767. Reviewed preprint at eLife. PMID: 37214855
Van der Heijden, ME*, Rey Hipolito, AG*, Kim, LH, Kizek, DJ, Perez, RM, Lin, T, Sillitoe, RV. (2023) Glutamatergic cerebellar neurons differentially contribute to the acquisition of motor and social behaviors. – Article in: Nature Communications. DOI: 10.1038/s41467-023-38475-9. PMID: 37188723
Zhou, J., Van der Heijden, M. E., Salazar Leon, L.E., Lin, T., Miterko, L.N., Kizek, D.J., Perez. R.M., Pavešković, M., Brown, A.M. Sillitoe, R.V. (2022) Propranolol modulates cerebellar circuit activity and reduces tremor. – Article in: Cells – DOI: 10.3390/cells11233889. PMID: 36497147
Van der Heijden, ME, Brown, AM, Sillitoe, RV. (2022) Influence of data sampling methods on the representation of neural spiking activity in vivo. Article in: iScience – DOI: 10.1016/j.isci.2022.105429. PMID: 36388953
Van der Heijden, ME, Gill, JS, Rey Hipolito, AG, Salazar Leon, LE, Sillitoe, RV. (2022) Quantification of Behavioral Deficits in Developing Mice with Dystonia-like Behaviors. Article in: Dystonia – DOI: 10.3389/dyst.2022.10494. PMID: 36960404
Brown, AM, Van der Heijden, ME, Jinnah, HA, Sillitoe, RV (2022). Cerebellar dysfunction as a source of dystonic phenotypes in mice. Article in: Cerebellum – DOI: 10.1007/s12311-022-01441-0. PMID: 35821365
Orengo, JP, Nitschke, L, Van der Heijden, ME, Ciaburri, N, Orr, H, Zoghbi, H (2022) Reduction of mutant ATXN1 rescues premature death in a conditional SCA1 mouse model. Article in: JCI Insight – DOI: 10.1172/jci.insight.154442. PMID: 35290244.
Liu, Y, McAfee, SS, Van der Heijden, ME, Dhamala, M, Sillitoe, RV, Heck, DH. (2022). Causal evidence for cerebellar role in prefrontal-hippocampal interaction in spatial working memory decision-making. Article in: Cerebellum – DOI: 10.1007/s12311-022-01383-7. PMID: 35218525
Stevens, SR, Van der Heijden, ME, Ogawa, Y, Lin, T, Sillitoe, RV, Rasband, MN. (2022) Ankyrin-R links Kv3.3 to the spectrin cytoskeleton and is required for Purkinje neuron survival. Article in: Journal of Neuroscience – DOI:10.1523/JNEUROSCI.1132-21. PMID: 34785580 #Cover image
Van der Heijden, ME, Lackey, EP, Perez, R, Ișleyen, FS, Brown, AM, Lin, T, Zoghbi, HY, Sillitoe, RV (2021). Maturation of Purkinje cell firing properties relies on neurogenesis of excitatory neurons. Article in: eLife – DOI:10.7554/eLife.68045. PMID: 34542409
eLife Digest: https://elifesciences.org/digests/68045/protecting-preterm-brains
Miterko, LN, Lin, T, Zhou, J, Van der Heijden, ME, Beckenhausen, J, White, JJ, Sillitoe, RV (2021). Neuromodulation of the cerebellum rescues movement in a mouse model of ataxia. Article in: Nature Communications – DOI:10.1038/ s41467-021-21417-8. PMID: 33637754
Van der Heijden, ME, Kizek, DJ, Perez, R, Ruff, EK, Ehrlich, ME, Sillitoe, RV (2021). Abnormal cerebellar function and tremor in a mouse model for non-manifesting DYT6. Article in: Journal of Physiology – DOI: 10.1113/JP280978. PMID: 33369735 #Cover image
Alcott, CE, Yalamanchili, HK, Ji, P, Van der Heijden, ME, Saltzman, AB, Leng, M, Bhatt, B, Hao, S, Wang, Q, Saliba, A, Tang, J, Malovannaya, A, Wagner, E, Liu, Z, Zoghbi, HY (2020) Partial loss of CFIm25 causes learning deficits and aberrant neuronal alternative polyadenylation. Article in: eLife - DOI: 10.7554/eLife.50895. PMID: 32319885
Brown, AM, White, JJ, Van der Heijden, ME, Zhou, J, Lin, T, Sillitoe, RV (2020) Purkinje cell misfiring generates high-amplitude action tremors that are corrected by cerebellar deep brain stimulation. Article in: eLife – DOI: 10.7554/eLife.51928. PMID: 32319885
Chen, CA, Wang, W, Pedersen, SE, Raman, A, Seymour, ML, Ruiz, FR, Van der Heijden, ME, Wang, L, Yin, J, Lopez, J, Rech, ME, Lewis, RA, Wu, SM, Liu, Z, Pereira, FA, Pautler, RG, Zoghbi, HY, Schaaf, CP (2020). Nr2f1 heterozygous knockout mice recapitulate neurological phenotypes of Bosch-Boonstra-Schaaf optic atrophy syndrome and show impaired hippocampal synaptic plasticity. Article in: Human Molecular Genetics – DOI: 10.1093/hmg.ddz233. PMID: 31600777
Van der Heijden, ME, Zoghbi, HY (2018) Loss of Atoh1 from neurons regulating hypoxic and hypercapnic chemoresponses causes neonatal respiratory failure in mice. Article in: eLife – DOI: 10.7554/eLife.38455. PMID: 29972353
eLife Digest: https://doi.org/10.7554/eLife.38455.002.
Orengo, JP, Van der Heijden, ME, Hao, S, Tang, J, Orr, HT, Zoghbi, HY (2018) Motor neuron degeneration correlates with respiratory dysfunction in SCA1. Article in: Disease models & mechanisms – DOI: 10.1242/dmm.032623. PMID: 29419414
Yeh, SY, Huang, WH, Wang, W, Ward, CS, Chao, E, Wu, Z, Tang, B, Tang, J, Sun, JJ, Van der Heijden, ME, Gray, PA, Xue, M, Ray, RS, Ren, D, Zoghbi, HY (2017) Respiratory network stability and modulatory response to substance P require Nalcn. Article in: Neuron – DOI: 10.1016/j.neuron.2017.03.024. PMID: 28392070
Van der Heijden, ME, Shah, P, Yang, Z, Cowan, C.S., Wu, SM, Frankfort, BJ (2016) Effect of Elevated Intraocular Pressure on Photopic and Scotopic Contrast Sensitivity in Mice. Article in: Investigative Ophthalmology & Visual Sciences – DOI:10.1167/iovs.16-19312. PMID: 27286365
Cowan, CS, Abd-El-Barr, M, Van der Heijden, ME, Lo, EM, Paul, D, Bramblett, DE, Lem, J, Simons, D, Wu, SM. (2016) Connexin 36 and Rod Bipolar Cell-Independent Rod Pathways Drive Retinal Ganglion Cells and Optokinetic Reflexes. Article in: Vision Research – DOI: 10.1016/j.visres.2015.11.006. PMID: 26718442
Khan, AK, Tse, DY, Van der Heijden, ME, Shah, P, Nusbaum, DM, Yang, Z, Wu, SM & Frankfort, BJ (2015) Prolonged elevation of intraocular pressure results in retinal ganglion cell loss and abnormal retinal function in mice. Article in: Experimental Eye Research – DOI:10.1016/j.exer.2014.11.00. PMID: 25450059
Published Review Articles / Book Chapters
Rey Hipolito, AG*, Van der Heijden, ME*, Sillitoe, RV. (2023) Physiology of Dystonia: Animal Models. – Book chapter in: The neurobiology of dystonia (editors: Jinnah, Albanese, and Bhatia). DOI: 10.1016/bs.irn.2023.05.004. PMID: 37482392
Van der Heijden, ME, Brown, AM, Sillitoe, RV (2022) Silencing the output of cerebellar neurons using cell type-specific genetic deletion of vesicular GABA and glutamate transporters. Book Chapter in: Neuromethods: Measuring Cerebellar Function – DOI:10.1007/978-1-0716-2026-7_3
Van der Heijden, ME**, Gill, JS, Sillitoe, RV** (2021) Abnormal cerebellar development in autism spectrum disorders. Review in: Developmental Neuroscience – DOI: 10.1159/000515189. PMID: 33823515
Van der Heijden, ME, Sillitoe, RV (2021) Interactions between Purkinje cells and granule cells coordinate the development of functional cerebellar circuits. Review in: Neuroscience – DOI: 10.1016/j.neuroscience.2020.06.010. PMID: 32554107
Van der Heijden, ME, Zoghbi, HY (2020) Development of the brainstem respiratory circuit. Review in: WIREs Dev Biol. – DOI: 10.1002/wdev.366. PMID: 31816185
Published Editorials / Previews / Blogs
Van der Heijden, ME (2023). Things I wish I knew before entering the Academic Job Market. Blog on: ecrLife. - https://ecrlife.org/things-to-know-academic-job-market/
Gill, JS, Van der Heijden, ME, Shaikh, AG, Sillitoe, RV (2023). Editorial: Models, mechanisms, and maturation in developmental dystonia. Editorial in: Dystonia – DOI: 10.3389/dyst.2023.11922.
Van der Heijden, ME, Brown, AM, Sillitoe, RV (2021) Motor control: Internalizing your place in the world. Dispatch in: Current Biology – DOI:10.1016/j.cub.2021.10.043. PMID: 34932966
Preprints / Articles in Review / Articles in Press / Articles in Preparation
Van der Heijden, ME^, Sillitoe, RV^. Cerebellar dysfunction in dystonia – the conundrum of one brain region’s involvement in multiple movement disorders. (2023) Invited mini-review, submitted to: Dystonia.
Gill, JS, Nguyen, MX, Hull, M, Van der Heijden, ME, Nguyen, K, Thomas, S, Sillitoe, RV. Function and dysfunction of the dystonia network: an exploration of the circuits underpinning the acquired and isolated dystonias. Submitted to: Dystonia
Van der Heijden, ME^ Converging and Diverging Cerebellar Pathways for Motor and Social Behaviors in Mice. Invited review in Cerebellum. In preparation.
Lackey, EP*, Van der Heijden, ME*, Lin, T, Sillitoe, RV. Loss of cerebellar input signals that control ongoing movement kinematics causes dystonia. Submitted to: Dystonia