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Dr. Weston's Publications

View Dr. Weston's publications on PubMed

Tobin WF, Weston MC. Distinct Features of Interictal Activity Predict Seizure Localization and Burden in a Mouse Model of Childhood Epilepsy. J Neurosci. 2023 Jul 5;43(27):5076-5091. doi: 10.1523/JNEUROSCI.2205-22.2023. Epub 2023 Jun 8. PMID: 37290938; PMCID: PMC10324994.

Cullen ER, Tariq K, Shore AN, Luikart BW, Weston MC. (2022) mTORC2 inhibition improves morphological effects of PTEN loss, but does not correct synaptic dysfunction or prevent seizures. Journal of Neuroscience. Dec 16. doi: 10.1523/JNEUROSCI.1354-22.2022. Epub ahead of print. PMID: 36526374.

Tariq K, Cullen E, Getz SA, Conching AK, Goyette AR, Prina ML, Wang W, Li M, Weston MC, Luikart BW. (2022) Disruption of mTORC1 rescues neuronal overgrowth and synapse function dysregulated by Pten loss. Cell Reports. Nov 1;41: 111574.

Tobin WF, Weston MC. (2021) Excess interictal activity marks seizure prone cortical areas and mice in a genetic epilepsy model. bioRxiv. doi:

McCabe MP, Shore AN, Frankel WN, Weston MC. Altered Fast Synaptic Transmission in a Mouse Model of DNM1-Associated Developmental Epileptic Encephalopathy. eNeuro. 2021 Mar-Apr;8(2). doi: 10.1523/ENEURO.0269-20.2020. Print 2021 Mar-Apr. PubMed PMID: 33372033; PubMed Central PMCID: PMC7986544.

Shore AN, Colombo S, Tobin WF, Petri S, Cullen ER, Dominguez S, Bostick CD, Beaumont MA, Williams D, Khodagholy D, Yang M, Lutz CM, Peng Y, Gelinas JN, Goldstein DB, Boland MJ, Frankel WN, Weston MC. Reduced GABAergic Neuron Excitability, Altered Synaptic Connectivity, and Seizures in a KCNT1 Gain-of-Function Mouse Model of Childhood Epilepsy. Cell Rep. 2020 Oct 27;33(4):108303. doi: 10.1016/j.celrep.2020.108303. PubMed PMID: 33113364; PubMed Central PMCID: PMC7712469.

Sah M, Shore AN, Petri S, Kanber A, Yang M, Weston MC, Frankel WN. Altered excitatory transmission onto hippocampal interneurons in the IQSEC2 mouse model of X-linked neurodevelopmental disease. Neurobiol Dis. 2020 Apr;137:104758. doi: 10.1016/j.nbd.2020.104758. Epub 2020 Jan 21. PubMed PMID: 31978606; PubMed Central PMCID: PMC7315256.

McCabe MP, Cullen ER, Barrows CM, Shore AN, Tooke KI, Laprade KA, Stafford JM, Weston MC. Genetic inactivation of mTORC1 or mTORC2 in neurons reveals distinct functions in glutamatergic synaptic transmission. Elife. 2020 Mar 3;9. doi: 10.7554/eLife.51440. PubMed PMID: 32125271; PubMed Central PMCID: PMC7080408.

Weston M. KCC2 Much Chloride Might Not Be the Only Problem. Epilepsy Curr. 2020 Jan-Feb;20(1):43-44. doi: 10.1177/1535759719890333. Epub 2019 Dec 12. PubMed PMID: 31826658; PubMed Central PMCID: PMC7020531.

Weston M. Jumping to Conclusions About Focal Seizure Spread. Epilepsy Curr. 2018 Nov-Dec;18(6):394-395. doi: 10.5698/1535-7597.18.6.394. PubMed PMID: 30568559; PubMed Central PMCID: PMC6278727.

Weston M. Trading up to a New Model of STXBP-Encephalopathy. Epilepsy Curr. 2018 Jul-Aug;18(4):257-259. doi: 10.5698/1535-7597.18.4.257. PubMed PMID: 30254526; PubMed Central PMCID: PMC6145383.

Tobin WF, Weston MC. Focusing on the Big Picture: Induced Focal Seizures Propagate Along Synaptic Pathways. Epilepsy Curr. 2018 Jan-Feb;18(1):47-48. doi: 10.5698/1535-7597.18.1.47. PubMed PMID: 29844765; PubMed Central PMCID: PMC5967589.

Weston MC. GRIN and Bear the Diverse Functional Effects of Rare NMDA Receptor Variants. Epilepsy Curr. 2017 Nov-Dec;17(6):381-383. doi: 10.5698/1535-7597.17.6.381. PubMed PMID: 29217988; PubMed Central PMCID: PMC5706366.

Barrows CM, McCabe MP, Chen H, Swann JW, Weston MC. PTEN Loss Increases the Connectivity of Fast Synaptic Motifs and Functional Connectivity in a Developing Hippocampal Network. J Neurosci. 2017 Sep 6;37(36):8595-8611. doi: 10.1523/JNEUROSCI.0878-17.2017. Epub 2017 Jul 27. PubMed PMID: 28751459; PubMed Central PMCID: PMC5588456.

Weston MC. Two Targets Are Better Than One: A New Strategy to Increase the Specificity of Anti-Epileptic Drugs. Epilepsy Curr. 2017 Jul-Aug;17(4):235-236. doi: 10.5698/1535-7597.17.4.235. PubMed PMID: 29225530; PubMed Central PMCID: PMC5716119.

Weston MC. The Role of PRRT2 in Synaptic Transmission May Not Be So Benign. Epilepsy Curr. 2017 May-Jun;17(3):165-166. doi: 10.5698/1535-7511.17.3.165. PubMed PMID: 28684951; PubMed Central PMCID: PMC5486426.

John Lin CC, Yu K, Hatcher A, Huang TW, Lee HK, Carlson J, Weston MC, Chen F, Zhang Y, Zhu W, Mohila CA, Ahmed N, Patel AJ, Arenkiel BR, Noebels JL, Creighton CJ, Deneen B. Identification of diverse astrocyte populations and their malignant analogs. Nat Neurosci. 2017 Mar;20(3):396-405. doi: 10.1038/nn.4493. Epub 2017 Feb 6. PubMed PMID: 28166219; PubMed Central PMCID: PMC5824716.

McCabe MP, Weston MC. Riding the Calcium Wave to a Better Understanding of Ictal Events. Epilepsy Curr. 2016 Sep-Oct;16(5):333-334. doi: 10.5698/1535-7511-16.5.333. PubMed PMID: 27799866; PubMed Central PMCID: PMC5083059.

Shore AN, Chang CH, Kwon OJ, Weston MC, Zhang M, Xin L, Rosen JM. PTEN is required to maintain luminal epithelial homeostasis and integrity in the adult mammary gland. Dev Biol. 2016 Jan 1;409(1):202-217. doi: 10.1016/j.ydbio.2015.10.023. Epub 2015 Oct 23. PubMed PMID: 26526198; PubMed Central PMCID: PMC4688181.

Weston MC, Chen H, Swann JW. Loss of mTOR repressors Tsc1 or Pten has divergent effects on excitatory and inhibitory synaptic transmission in single hippocampal neuron cultures. Front Mol Neurosci. 2014;7:1. doi: 10.3389/fnmol.2014.00001. eCollection 2014. PubMed PMID: 24574959; PubMed Central PMCID: PMC3922082.

Weston MC, Chen H, Swann JW. Multiple roles for mammalian target of rapamycin signaling in both glutamatergic and GABAergic synaptic transmission. J Neurosci. 2012 Aug 15;32(33):11441-52. doi: 10.1523/JNEUROSCI.1283-12.2012. PubMed PMID: 22895726; PubMed Central PMCID: PMC3432956.

Weston MC, Nehring RB, Wojcik SM, Rosenmund C. Interplay between VGLUT isoforms and endophilin A1 regulates neurotransmitter release and short-term plasticity. Neuron. 2011 Mar 24;69(6):1147-59. doi: 10.1016/j.neuron.2011.02.002. PubMed PMID: 21435559.

Chaudhry C, Weston MC, Schuck P, Rosenmund C, Mayer ML. Stability of ligand-binding domain dimer assembly controls kainate receptor desensitization. EMBO J. 2009 May 20;28(10):1518-30. doi: 10.1038/emboj.2009.86. Epub 2009 Apr 2. PubMed PMID: 19339989; PubMed Central PMCID: PMC2688536.

Martens H, Weston MC, Boulland JL, Grønborg M, Grosche J, Kacza J, Hoffmann A, Matteoli M, Takamori S, Harkany T, Chaudhry FA, Rosenmund C, Erck C, Jahn R, Härtig W. Unique luminal localization of VGAT-C terminus allows for selective labeling of active cortical GABAergic synapses. J Neurosci. 2008 Dec 3;28(49):13125-31. doi: 10.1523/JNEUROSCI.3887-08.2008. PubMed PMID: 19052203; PubMed Central PMCID: PMC6671625.

Albright MJ, Weston MC, Inan M, Rosenmund C, Crair MC. Increased thalamocortical synaptic response and decreased layer IV innervation in GAP-43 knockout mice. J Neurophysiol. 2007 Sep;98(3):1610-25. doi: 10.1152/jn.00219.2007. Epub 2007 Jun 20. PubMed PMID: 17581849.

Weston MC, Schuck P, Ghosal A, Rosenmund C, Mayer ML. Conformational restriction blocks glutamate receptor desensitization. Nat Struct Mol Biol. 2006 Dec;13(12):1120-7. doi: 10.1038/nsmb1178. Epub 2006 Nov 19. PubMed PMID: 17115050.

Moechars D, Weston MC, Leo S, Callaerts-Vegh Z, Goris I, Daneels G, Buist A, Cik M, van der Spek P, Kass S, Meert T, D'Hooge R, Rosenmund C, Hampson RM. Vesicular glutamate transporter VGLUT2 expression levels control quantal size and neuropathic pain. J Neurosci. 2006 Nov 15;26(46):12055-66. doi: 10.1523/JNEUROSCI.2556-06.2006. PubMed PMID: 17108179; PubMed Central PMCID: PMC6674853.

Weston MC, Gertler C, Mayer ML, Rosenmund C. Interdomain interactions in AMPA and kainate receptors regulate affinity for glutamate. J Neurosci. 2006 Jul 19;26(29):7650-8. doi: 10.1523/JNEUROSCI.1519-06.2006. PubMed PMID: 16855092; PubMed Central PMCID: PMC6674271.

Stornetta RL, Rosin DL, Simmons JR, McQuiston TJ, Vujovic N, Weston MC, Guyenet PG. Coexpression of vesicular glutamate transporter-3 and gamma-aminobutyric acidergic markers in rat rostral medullary raphe and intermediolateral cell column. J Comp Neurol. 2005 Nov 28;492(4):477-94. doi: 10.1002/cne.20742. PubMed PMID: 16228993.

Mulkey DK, Stornetta RL, Weston MC, Simmons JR, Parker A, Bayliss DA, Guyenet PG. Respiratory control by ventral surface chemoreceptor neurons in rats. Nat Neurosci. 2004 Dec;7(12):1360-9. doi: 10.1038/nn1357. Epub 2004 Nov 21. PubMed PMID: 15558061; NIHMSID:NIHMS439751.

Weston MC, Stornetta RL, Guyenet PG. Glutamatergic neuronal projections from the marginal layer of the rostral ventral medulla to the respiratory centers in rats. J Comp Neurol. 2004 May 17;473(1):73-85. doi: 10.1002/cne.20076. PubMed PMID: 15067719.

Wang H, Weston MC, McQuiston TJ, Stornetta RL, Guyenet PG. Neurokinin-1 receptor-expressing cells regulate depressor region of rat ventrolateral medulla. Am J Physiol Heart Circ Physiol. 2003 Dec;285(6):H2757-69. doi: 10.1152/ajpheart.00528.2003. Epub 2003 Aug 21. PubMed PMID: 12933345.

Rosin DL, Weston MC, Sevigny CP, Stornetta RL, Guyenet PG. Hypothalamic orexin (hypocretin) neurons express vesicular glutamate transporters VGLUT1 or VGLUT2. J Comp Neurol. 2003 Oct 27;465(4):593-603. doi: 10.1002/cne.10860. PubMed PMID: 12975818.

Weston M, Wang H, Stornetta RL, Sevigny CP, Guyenet PG. Fos expression by glutamatergic neurons of the solitary tract nucleus after phenylephrine-induced hypertension in rats. J Comp Neurol. 2003 Jun 9;460(4):525-41. doi: 10.1002/cne.10663. PubMed PMID: 12717712.

Stornetta RL, Rosin DL, Wang H, Sevigny CP, Weston MC, Guyenet PG. A group of glutamatergic interneurons expressing high levels of both neurokinin-1 receptors and somatostatin identifies the region of the pre-Bötzinger complex. J Comp Neurol. 2003 Jan 20;455(4):499-512. doi: 10.1002/cne.10504. PubMed PMID: 12508323.

Guyenet PG, Sevigny CP, Weston MC, Stornetta RL. Neurokinin-1 receptor-expressing cells of the ventral respiratory group are functionally heterogeneous and predominantly glutamatergic. J Neurosci. 2002 May 1;22(9):3806-16. doi: 20026330. PubMed PMID: 11978856; PubMed Central PMCID: PMC6758383.