Dr. Gourdie's Publications

For a more complete list of publications, visit the following publication sites: PubMed

Zhang A, Hitomi M, Bar-Shain N, Dalimov Z, Ellis L, Velpula KK, Fraizer GC, Gourdie RG, Lathia JD. Correction: Connexin 43 expression is associated with increased malignancy in prostate cancer cell lines and functions to promote migration. Oncotarget. 2023 May 4;14:417-418. doi: 10.18632/oncotarget.28411. Erratum for: 11640-11651. PMID: 37141414; PMCID: PMC10159365.

Teng ACT, Gu L, Di Paola M, Lakin R, Williams ZJ, Au A, Chen W, Callaghan NI, Zadeh FH, Zhou YQ, Fatah M, Chatterjee D, Jourdan LJ, Liu J, Simmons CA, Kislinger T, Yip CM, Backx PH, Gourdie RG, Hamilton RM, Gramolini AO. Tmem65 is critical for the structure and function of the intercalated discs in mouse hearts. Nat Commun. 2022 Oct 18;13(1):6166. doi: 10.1038/s41467-022-33303-y. PMID: 36257954; PMCID: PMC9579145.

Tasdemiroglu Y, Gourdie RG, He JQ. In vivo degradation forms, anti-degradation strategies, and clinical applications of therapeutic peptides in non-infectious chronic diseases. Eur J Pharmacol. 2022 Oct 15;932:175192. doi: 10.1016/j.ejphar.2022.175192. Epub 2022 Aug 16. PMID: 35981605.

Pridham KJ, Shah F, Hutchings KR, Sheng KL, Guo S, Liu M, Kanabur P, Lamouille S, Lewis G, Morales M, Jourdan J, Grek CL, Ghatnekar GG, Varghese R, Kelly DF, Gourdie RG, Sheng Z. Connexin 43 confers chemoresistance through activating PI3K. Oncogenesis. 2022 Jan 12;11(1):2. doi: 10.1038/s41389-022-00378-7. PMID: 35022385; PMCID: PMC8755794.

Gourdie RG. The enigmatic role of macrophages in cardiac electrical signaling. Cardiovasc Res. 2021 Dec 11:cvab358. doi: 10.1093/cvr/cvab358. Epub ahead of print. PMID: 34894215.

Morningstar JE, Gensemer C, Moore R, Fulmer D, Beck TC, Wang C, Moore K, Guo L, Sieg F, Nagata Y, Bertrand P, Spampinato RA, Glover J, Poelzing S, Gourdie RG, Watts K, Richardson WJ, Levine RA, Borger MA, Norris RA. Mitral Valve Prolapse Induces Regionalized Myocardial Fibrosis. J Am Heart Assoc. 2021 Dec 21;10(24):e022332. doi: 10.1161/JAHA.121.022332. Epub 2021 Dec 7. PMID: 34873924.

Wu X, Hoeker GS, Blair GA, King DR, Gourdie RG, Weinberg SH, Poelzing S. Hypernatremia and intercalated disc edema synergistically exacerbate long-QT syndrome type 3 phenotype. Am J Physiol Heart Circ Physiol. 2021 Dec 1;321(6):H1042-H1055. doi: 10.1152/ajpheart.00366.2021. Epub 2021 Oct 8. PMID: 34623182.

Strauss RE, Mezache L, Veeraraghavan R, Gourdie RG. The Cx43 Carboxyl-Terminal Mimetic Peptide αCT1 Protects Endothelial Barrier Function in a ZO1 Binding-Competent Manner. Biomolecules. 2021 Aug 12;11(8):1192. doi: 10.3390/biom11081192. PMID: 34439858; PMCID: PMC8393261.

Marsh SR, Pridham KJ, Jourdan J, Gourdie RG. Novel Protocols for Scalable Production of High Quality Purified Small Extracellular Vesicles from Bovine Milk. Nanotheranostics 2021; 5(4):488-498. doi:10.7150/ntno.62213.

Montgomery J, Richardson WJ, Marsh S, Rhett JM, Bustos F, Degen K, Ghatnekar GS, Grek CL, Jourdan LJ, Holmes JW, Gourdie RG. The connexin 43 carboxyl terminal mimetic peptide αCT1 prompts differentiation of a collagen scar matrix in humans resembling unwounded skin. FASEB J. 2021 Aug;35(8):e21762. doi: 10.1096/fj.202001881R. PMID: 34246197.

Marsh SR, Williams ZJ, Pridham KJ, Gourdie RG. Peptidic Connexin43 Therapeutics in Cardiac Reparative Medicine. J Cardiovasc Dev Dis. 2021 May 5;8(5):52. doi: 10.3390/jcdd8050052. PMID: 34063001; PMCID: PMC8147937.

Olejnickova V, Kocka M, Kvasilova A, Kolesova H, Dziacky A, Gidor T, Gidor L, Sankova B, Gregorovicova M, Gourdie RG, Sedmera D. Gap Junctional Communication via Connexin43 between Purkinje Fibers and Working Myocytes Explains the Epicardial Activation Pattern in the Postnatal Mouse Left Ventricle. Int J Mol Sci. 2021 Mar 1;22(5):2475. doi: 10.3390/ijms22052475. PMID: 33804428; PMCID: PMC7957598.

Strauss RE, Gourdie RG. Cx43 and the Actin Cytoskeleton: Novel Roles and Implications for Cell-Cell Junction-Based Barrier Function Regulation. Biomolecules. 2020 Dec 10;10(12):1656. doi: 10.3390/biom10121656. PMID: 33321985; PMCID: PMC7764618.

Hoeker GS, James CC, Tegge AN, Gourdie RG, Smyth JW, Poelzing S. Attenuating loss of cardiac conduction during no-flow ischemia through changes in perfusate sodium and calcium. Am J Physiol Heart Circ Physiol. 2020 Aug 1;319(2):H396-H409. doi: 10.1152/ajpheart.00112.2020. Epub 2020 Jul 17. PMID: 32678707; PMCID: PMC7473923.

Roberts R, Smyth JW, Will J, Roberts P, Grek CL, Ghatnekar GS, Sheng Z, Gourdie RG, Lamouille S, Foster EJ. Development of PLGA nanoparticles for sustained release of a connexin43 mimetic peptide to target glioblastoma cells. Mater Sci Eng C Mater Biol Appl. 2020 Mar;108:110191. doi: 10.1016/j.msec.2019.110191. Epub 2019 Sep 12. PMID: 31923988.

Jiang J, Hoagland D, Palatinus JA, He H, Iyyathurai J, Jourdan LJ, Bultynck G, Wang Z, Zhang Z, Schey K, Poelzing S, McGowan FX, Gourdie RG. Interaction of α Carboxyl Terminus 1 Peptide With the Connexin 43 Carboxyl Terminus Preserves Left Ventricular Function After Ischemia-Reperfusion Injury. J Am Heart Assoc. 2019 Aug 20;8(16):e012385. doi: 10.1161/JAHA.119.012385. Epub 2019 Aug 19. PMID: 31422747; PMCID: PMC6759879.

Schultz F, Swiatlowska P, Alvarez-Laviada A, Sanchez-Alonso JL, Song Q, de Vries AAF, Pijnappels DA, Ongstad E, Braga VMM, Entcheva E, Gourdie RG, Miragoli M, Gorelik J. (2019). Cardiomyocyte-myofibroblast contact dynamism is modulated by connexin-43. FASEB J 33(9): 10453-10468. doi: 10.1096/fj.201802740RR.

Jiang J, Hoagland D, Palatinus JA, He H, Iyyathurai J, Jourdan LJ, Bultynck G, Wang Z, Zhang Z, Schey K, Poelzing S, McGowan FX, Gourdie RG. (2019). Interaction of α Carboxyl Terminus 1 Peptide With the Connexin 43 Carboxyl Terminus Preserves Left Ventricular Function After Ischemia-Reperfusion Injury. J Am Heart Assoc 8(6): e012385. doi: 10.1161/JAHA.119.012385.

Hoagland DT, Santos W, Poelzing S, Gourdie RG. (2019). The role of the gap junction perinexus in cardiac conduction: Potential as a novel anti-arrhythmic drug target. Prog Biophys Mol Biol 144: 41-50. doi: 10.1016/j.pbiomolbio.2018.08.003.

George SA, Hoeker G, Calhoun PJ, Entz M 2nd, Raisch TB, King DR, Khan M, Baker C, Gourdie RG, Smyth JW, Nielsen MS, Poelzing S. (2019). Modulating cardiac conduction during metabolic ischemia with perfusate sodium and calcium in guinea pig hearts. Am J Physiol Heart Circ Physiol 316(4): H849-H861. doi: 10.1152/ajpheart.00083.2018.

Gourdie RG. (2019). The Cardiac Gap Junction has Discrete Functions in Electrotonic and Ephaptic Coupling. Anat Rec (Hoboken) 302(1): 93-100. doi: 10.1002/ar.24036.

Veeraraghavan R, Hoeker GS, Alvarez-Laviada A, Hoagland D, Wan X, King DR, Sanchez-Alonso J, Chen C, Jourdan J, Isom LL, Deschenes I, Smyth JW, Gorelik J, Poelzing S, Gourdie RG. (2018). The adhesion function of the sodium channel beta subunit (β1) contributes to cardiac action potential propagation. Elife: 7. pii: e37610. doi: 10.7554/eLife.37610.

Grek CL, Sheng Z, Naus CC, Sin WC, Gourdie RG, Ghatnekar GG. (2018). Novel approach to temozolomide resistance in malignant glioma: connexin43-directed therapeutics. Curr Opin Pharmacol: 41:79-88. doi: 10.1016/j.coph.2018.05.002.

Raisch TB, Yanoff MS, Larsen TR, Farooqui MA, King DR, Veeraraghavan R, Gourdie RG, Baker JW, Arnold WS, AlMahameed ST, Poelzing S. (2018). Intercalated Disk Extracellular Nanodomain Expansion in Patients With Atrial Fibrillation. Front Physiol: 9:398. doi: 10.3389/fphys.2018.00398.

Lindsey ML, Bolli R, Canty JM Jr, Du XJ, Frangogiannis NG, Frantz S, Gourdie RG, Holmes JW, Jones SP, Kloner RA, Lefer DJ, Liao R, Murphy E, Ping P, Przyklenk K, Recchia FA, Schwartz Longacre L, Ripplinger CM, Van Eyk JE, Heusch G. (2018). Guidelines for experimental models of myocardial ischemia and infarction. Am J Physiol Heart Circ Physiol 314(4): H812-H838. doi: 10.1152/ajpheart.00335.2017.

Rhett JM, Calder BW, Fann SA, Bainbridge H, Gourdie RG, Yost MJ. (2017). Mechanism of action of the anti-inflammatory connexin43 mimetic peptide JM2. Am J Physiol Cell Physiol 313(3): C314-C326. doi: 10.1152/ajpcell.00229.2016.

Greer K, Chen J, Brickler T, Gourdie R, Theus MH. (2017). Modulation of gap junction-associated Cx43 in neural stem/progenitor cells following traumatic brain injury. Brain Res Bull 134: 38-46. doi: 10.1016/j.brainresbull.2017.06.016.

George SA, Calhoun PJ, Gourdie RG, Smyth JW, Poelzing S. (2017). TNFα Modulates Cardiac Conduction by Altering Electrical Coupling between Myocytes. Front Physiol: 8:334. doi: 10.3389/fphys.2017.00334.

Obert E, Strauss R, Brandon C, Grek C, Ghatnekar G, Gourdie R, Rohrer B. (2017). Targeting the tight junction protein, zonula occludens-1, with the connexin43 mimetic peptide, αCT1, reduces VEGF-dependent RPE pathophysiology. J Mol Med (Berl) 95(5): 535-552. doi: 10.1007/s00109-017-1506-8.

Grek CL, Montgomery J, Sharma M, Ravi A, Rajkumar JS, Moyer KE, Gourdie RG, Ghatnekar GS. (2017). A Multicenter Randomized Controlled Trial Evaluating a Cx43-Mimetic Peptide in Cutaneous Scarring. J Invest Dermatol 137(3): 620-630. doi: 10.1016/j.jid.2016.11.006.

Kanabur P, Guo S, Simonds GR, Kelly DF, Gourdie RG, Verbridge SS, Sheng Z. (2016). Patient-derived glioblastoma stem cells respond differentially to targeted therapies. Oncotarget 7(52): 86406-86419. doi: 10.18632/oncotarget.13415.

Veeraraghavan R, Gourdie RG. (2016). Stochastic Optical Reconstruction Microscopy-based Relative Localization Analysis (STORM-RLA) for Quantitative Nanoscale Assessment of Spatial Protein Organization. Mol Biol Cell. 

Murphy SF, Varghese RT, Lamouille S, Guo S, Pridham KJ, Kanabur P, Osimani AM, Sharma S, Jourdan J, Rodgers CM, Simonds GR, Gourdie RG, Sheng Z. (2016). Connexin 43 Inhibition Sensitizes Chemoresistant Glioblastoma Cells to Temozolomide. Cancer Research 76(1): 139-49.

Veeraraghavan R, Lin J, Keener JP, Gourdie RG, Poelzing S. (2016). Potassium Channels in the Cx43 Gap Junction Perinexus Modulate Ephaptic Coupling: An Experimental and Modeling Study. Pflugers Archiv.

Kuczma M, Wang CY, Ignatowicz L, Gourdie RG, Kraj P. (2015). Altered connexin 43 expression underlies age-dependent decrease of regulatory T cell suppressor function in nonobese diabetic mice. Journal of Immunology 194(11): 5261-71.

Gourdie RG, Dimmeler S, Kohl P. (2015). Novel therapeutic strategies targeting fibroblasts in heart disease. Nature Reviews: Drug Discover.

Veeraraghavan R, Lin J, Hoeker GS, Keener JP*, Gourdie RG*, Poelzing S*. (2015). Sodium channels in the Cx43 gap junction perinexus may constitute a cardiac ephapse: an experimental and modeling study. Pflugers Archive - European Journal of Physiology.

Ghatnekar GS, Grek CL, Armstrong DG, Desai SC, Gourdie RG. (2015). The effect of a connexin43-based peptide on the healing of chronic venous leg ulcers: a multi center randomized trial. Journal of Investigative Dermatology (Nature) 135(1): 289-98.

Veeraraghavan R, Poelzing S, Gourdie RG. (2014). Novel ligands for zipping and unzipping the intercalated disk: today's experimental tools, tomorrow's therapies? Cardiovasc Res 104(2): 229-30.

Veeraraghavan R, Poelzing S, Gourdie RG. (2014). Intercellular electrical communication in the heart: a new, active role for the intercalated disk. Cell Commun Adhes.

Veeraraghavan R, Gourdie RG, Poelzing S. (2014). Mechanisms of Cardiac Conduction: A History of Revisions. Am J Physiol Heart Circ Physiol 306(5): H619-27.

Veeraraghavan R, Poelzing S, Gourdie RG. (2014). Old Cogs, New Tricks: A Scaffolding Role For Connexin43 And A Junctional Role For Sodium Channels?. FEBS Lett.

Gourdie RG, Myers TA. (2013). Methods in Molecular Biology. Humana Press.

Rhett JM, Veeraraghavahan S, Poelzing S, Gourdie RG. (2013). The perinexus: Sign-post on the path to a new model of cardiac conduction? Trends in Cardiovascular Medicine.

D'hondt C, Iyyathurai J, Wang N, Gourdie RG, Himpens B, Leybaert L, Bultynck G. (2013). Negatively charged residues (Asp278 and Asp279) in the last ten amino acids of the C-terminal tail of Cx43 hemichannels are essential for loop/tail interactions. Biochem Biophys Res Commun. 

Ongstad EL, Yost MJ, Fann SA, Ghatnekar GS, Gourdie RG. (2013). Regenerative pharmacology of implanted materials and tissue engineered constructs. In: Christ G (Ed.), Regenerative Pharmacology. Cambridge University Press.

Degen KE, Gourdie RG. (2012). Embryonic wound healing: A primer for engineering novel therapies for tissue repair. Birth Defects Res C Embryo Today 96(3): 258-70. 

Palatinus JA, Rhett JM, Gourdie RG. (2012). The connexin43 carboxyl terminus and cardiac gap junction organization. Biochimica et Biophysica Acta: in press.

Rhett JM, Jourdan J, Gourdie RG. (2011). Connexin 43 connexon to gap junction transition is regulated by zonula occludens-1. Molecular Biology of the Cell 22(9): 1516-28.

O'Quinn MP, Palatinus JA, Harris BS, Hewett KW, Gourdie RG. (2011). A peptide mimetic of the connexin43 carboxyl terminus reduces gap junction remodeling and induced arrhythmia following ventricular injury. Circulation Research 108(6): 704-15.

Ghatnekar GS*, O'Quinn MP*, Jourdan LJ, Gurjarpadhye AA*, Draughn RL, Gourdie RG. (2009). Connexin43 carboxyl-terminal peptides reduce scar progenitor and promote regenerative healing following skin wounding. Regenerative Medicine 4(2): 205-23.

Hunter AW, Barker RJ, Zhu C, Gourdie RG. (2006). Zonula occludens-1 alters connexin43 gap junction size and organization by influencing channel accretion. Molecular Biology of the Cell 16(12): 5686-98.