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Dr. Johnstone's Publications

For a more complete list of publications, visit the following publication sites: ResearchGate or ORCiD

Sedovy MW, Renton MC, Roberts K, Leng X, Dennison CL, Toler CO, Leaf MR, Lampe PD, Best AK, Isakson BE, Johnstone SR. Injury-induced connexin 43 expression regulates endothelial wound healing. Am J Physiol Heart Circ Physiol. 2025 Nov 1;329(5):H1361-H1377. doi: 10.1152/ajpheart.00153.2025. Epub 2025 Oct 8. PubMed PMID: 41060772; NIHMSID:NIHMS2116817.

Sedovy MW, Renton MC, Roberts K, Leng X, Dennison CL, Leaf MR, Lampe PD, Best AK, Isakson BE, Johnstone SR. Injury Induced Connexin 43 Expression Regulates Endothelial Wound Healing. bioRxiv. 2025 Feb 28;. doi: 10.1101/2025.02.24.639946. PubMed PMID: 40060672; PubMed Central PMCID: PMC11888281.

Sreedevi K, Zaitsev AV, Doku A, Thomas R, James A, Do S, Zhang M, Sedovy MW, Leng X, Dennison CL, Johnstone SR, Kirk JA, Yan Z, Warren JS. Adeno-associated virus-mediated gene delivery of Perm1 enhances cardiac contractility in mice. Am J Physiol Heart Circ Physiol. 2024 Oct 1;327(4):H1112-H1118. doi: 10.1152/ajpheart.00545.2024. Epub 2024 Sep 13. PubMed PMID: 39269449; PubMed Central PMCID: PMC11482265.

Luse MA, Dunaway LS, Nyshadham S, Carvalho A, Sedovy MW, Ruddiman CA, Tessema R, Hirschi K, Johnstone SR, Isakson BE. Endothelial-adipocyte Cx43 Mediated Gap Junctions Can Regulate Adiposity. Function (Oxf). 2024 Sep 10;5(5). doi: 10.1093/function/zqae029. PubMed PMID: 38984993; PubMed Central PMCID: PMC11384900.

Wolpe AG, Luse MA, Baryiames C, Schug WJ, Wolpe JB, Johnstone SR, Dunaway LS, Juśkiewicz ZJ, Loeb SA, Askew Page HR, Chen YL, Sabapathy V, Pavelec CM, Wakefield B, Cifuentes-Pagano E, Artamonov MV, Somlyo AV, Straub AC, Sharma R, Beier F, Barrett EJ, Leitinger N, Pagano PJ, Sonkusare SK, Redemann S, Columbus L, Penuela S, Isakson BE. Pannexin-3 stabilizes the transcription factor Bcl6 in a channel-independent manner to protect against vascular oxidative stress. Sci Signal. 2024 Jan 30;17(821):eadg2622. doi: 10.1126/scisignal.adg2622. Epub 2024 Jan 30. PubMed PMID: 38289985; PubMed Central PMCID: PMC11960805.

Sedovy MW, Leng X, Iqbal F, Renton MC, Leaf M, Roberts K, Malek A, Arnold WS, Wyatt DA, Choate CW, Rowe JF, Baker JW, Johnstone SR, Joseph M. Preserving Endothelial Integrity in Human Saphenous Veins during Preparation for Coronary Bypass Surgery. J Vasc Res. 2024;61(2):68-76. doi: 10.1159/000535843. Epub 2024 Jan 12. PubMed PMID: 38219725.

Mezache L, Soltisz AM, Johnstone SR, Isakson BE, Veeraraghavan R. Vascular Endothelial Barrier Protection Prevents Atrial Fibrillation by Preserving Cardiac Nanostructure. JACC Clin Electrophysiol. 2023 Dec;9(12):2444-2458. doi: 10.1016/j.jacep.2023.10.013. Epub 2023 Nov 29. PubMed PMID: 38032579; PubMed Central PMCID: PMC11134328.

Scott H, Dong L, Stevenson A, MacDonald AI, Srinivasan S, Massimi P, Banks L, Martin PE, Johnstone SR, Graham SV. The human discs large protein 1 interacts with and maintains connexin 43 at the plasma membrane in keratinocytes. J Cell Sci. 2023 Jun 1;136(11). doi: 10.1242/jcs.259984. Epub 2023 Jun 8. PubMed PMID: 37288673; PubMed Central PMCID: PMC10309592.

Payne LB, Abdelazim H, Hoque M, Barnes A, Mironovova Z, Willi CE, Darden J, Houk C, Sedovy MW, Johnstone SR, Chappell JC. A Soluble Platelet-Derived Growth Factor Receptor-β Originates via Pre-mRNA Splicing in the Healthy Brain and Is Upregulated during Hypoxia and Aging. Biomolecules. 2023 Apr 21;13(4). doi: 10.3390/biom13040711. PubMed PMID: 37189457; PubMed Central PMCID: PMC10136073.

Payne LB, Abdelazim H, Hoque M, Barnes A, Mironovova Z, Willi CE, Darden J, Jenkins-Houk C, Sedovy MW, Johnstone SR, Chappell JC. A Soluble Platelet-Derived Growth Factor Receptor-β Originates via Pre-mRNA Splicing in the Healthy Brain and is Differentially Regulated during Hypoxia and Aging. bioRxiv [Preprint]. 2023 Feb 4:2023.02.03.527005. doi: 10.1101/2023.02.03.527005. PMID: 36778261; PMCID: PMC9915746.

Sedovy MW, Leng X, Leaf MR, Iqbal F, Payne LB, Chappell JC, Johnstone SR. Connexin 43 across the Vasculature: Gap Junctions and Beyond. J Vasc Res. 2022 Dec 13:1-13. doi: 10.1159/000527469. Epub ahead of print. PMID: 36513042.

Louisa Mezache, Andrew M. Soltisz, Scott R. Johnstone, Brant Isakson, Rengasayee Veeraraghavan. Vascular endothelial barrier protection prevents nanoscale cardiac remodeling: a novel strategy to prevent atrial fibrillation. Biophysical Journal. 11 Feb. 2022. Volume 121, Issue 3, Supplement 1. 

D. Ryan King, Meghan W. Sedovy, Xinyan Leng, Jianxiang Xue, Samy Lamouille,Michael Koval, Brant E. Isakson and Scott R. Johnstone. Mechanisms of Connexin Regulating Peptides. September 2021. International Journal of Molecular Sciences 22(19):10186 DOI: 10.3390/ijms221910186

Daniela Maier-Begandt, Skye Comstra, Samuel A. Molina, Nenja Krüger, Claire A. Ruddiman, Yen-Lin Chen, Xiaobin Chen, Lauren A. Biwer, Scott R. Johnstone, Alexander W. Lohman, Miranda E. Good, Leon J. DeLalio, Kwangseok Hong, Hannah M. Bacon, Zhen Yan, Swapnil K. Sonkusare, Michael Kovaland Brant E. Isakson. (2021) A venous-specific purinergic signaling cascade initiated by Pannexin 1 regulates TNFα-induced increases in endothelial permeability. Science Signaling. 02 Mar 2021: Vol. 14, Issue 672, eaba2940 DOI: 10.1126/scisignal.aba2940

Miranda E. Good, Alexander P. Young, Abigail G. Wolpe, Manxiu Ma, Philip J. Hall, Colleen K. Duffy, Mark J. Aronovitz, Gregory L. Martin, Robert M. Blanton, Norbert Leitinger, Scott R. Johnstone, Matthew J. Wolf, Brant E. Isakson. (2021) Endothelial Pannexin 1 Regulates Cardiac Response to Myocardial Infarction. Circulation Research. 2021;128:1211–1213.

Leigh Anne Swayne, Scott R. Johnstone, Chen Seng Ng, Juan C. Sanchez-Arias, Miranda E. Good, Silvia Penuela, Alexander W. Lohman, Abigail G. Wolpe, Victor E. Laubach, Michael Koval, and Brant E. Isakson. (2020) Consideration of Pannexin 1 channels in COVID-19 pathology and treatment. Lung Cellular and Molecular Physiology. 30 JUN 2020 

Leon J. DeLalio, Ester Masati, SureshMendu, Claire A.  Ruddiman, YangYang, Scott R. Johnstone, Jenna A. Milstein, T.C. Stevenson Keller IV, Rachel B. Weaver, Nick A. Guagliardo, Angela K. Best, Kodi S. Ravichandran, Douglas A. Bayliss, Maria Luisa S. Sequeira-Lopez, Swapnil N. Sonkusare, Xiaohong H.Shu, BimalDesai, Paula Q.Barrett … Brant E.Isakson. (2020) Pannexin 1 channels in renin-expressing cells influence renin secretion and blood pressure homeostasis. Kidney International. Volume 98, Issue 3.

Yang Yang, Leon Delalio, Angela K. Best, Edgar Maccal, Daniela Begandt, Chen-Hsuin Lee, Jenna Milstein, Iona Donnelly, Ashley M. Miller Martin McBride, Xiaohong H. Shu, Michael Koval, Brant E. Isakson and Scott R. Johnstone. Endothelial Pannexin 1 Channels Control Inflammation by Regulating Intracellular Calcium. The J. of Immunol. 2020 Jun 1;204(11):2995-3007. PMID 32312847

  • Commentary by Juan C Sanchez Arias et al. PANX1 in inflammation heats up: New mechanistic insights with implications for injury and infection. Cell Calcium 2020 Jul 13;90:102253. PMID: 32688074

Leigh Anne Swayne, Scott R Johnstone, Chen Seng Ng, Juan C Sanchez-Arias, Miranda E Good, Silvia Penuela, Alexander W Lohman, Abigail G Wolpe, Victor E Laubach, Michael Koval, Brant E Isakson. Consideration of Pannexin 1 channels in COVID-19 pathology and treatment. Am J Physiol Lung Cell Mol Physiol. 2020 Jul 1;319(1):L121-L125. PMID: 32519892

Leon J DeLalio, Ester Masati, Suresh Mendu, Claire A Ruddiman, Yang Yang, Scott R Johnstone, Jenna A. Milstein, T.C. Stevenson Keller IV, Rachel B Weaver, Nick A. Guagliardo, Angela K Best, Kodi Ravichandran, Douglas A Bayliss, Maria Luisa S. Sequeira-Lopez, Swapnil N. Sonkusare, Bimal Desai, Paula Q. Barrett, Thu H. Le, Ariel R Gomez, and Brant E Isakson. Pannexin 1 channels in renin-expressing cells regulate renin secretion and blood pressure homeostasis. Kindey Int. 2020;S0085-2538(20)30543-3. doi: 10.1016/j.kint.2020.04.041

  • Commentary by Francois Alhenc-Gelas. A new channel for the control of renin secretion in juxtaglomerular cells. Kidney Int. 2020 Sep;98(3):543-545. PMID: 32828234

Matteo Ottolini, Kwangseok Hong, Eric L. Cope, Zdravka Daneva, Leon J. DeLalio, Jennifer D. Sokolowski, Corina Marziano, Nhiem Y. Nguyen, Joachim Altschmied, Judith Haendeler, Scott R. Johnstone, Mohammad Y. Kalani, Min S. Park, Rakesh P. Patel, Wolfgang Liedtke, Brant E. Isakson, Swapnil K. Sonkusare.  Local Peroxynitrite Impairs Endothelial TRPV4 Channels and Elevates Blood Pressure in Obesity. Circulation 2020 Apr 21;141(16):1318-1333. PMID: 32008372

Leon J. DeLalio, Marie Billaud, Claire A. Ruddiman, Scott R. Johnstone, Joshua T. Butcher, A G. Wolpe, X Jin, T.C. Steven Keller, T. Riviera, Miranda E. Good, Angela K. Best, Alexander W. Lohman, Silvia Penuela, Roger J. Thompson, Paul D. Lampe, Mark Y. Yeager and Brant E. Isakson. Constitutive SRC-mediated phosphorylation of pannexin 1 at tyrosine 198 occurs at the plasma membrane. J Biol Chem. 26;294(17):6940-6956; 2019. PMID: 30814251.

Leon J. DeLalio, Alexander S. Keller, Jiwang Chen, Andrew K.J. Boyce, Mykhaylo Artamonov, Henry R. Askew-Page, T.C. Steven Keller 4th, Scott R. Johnstone, Rachel B. Weaver, Miranda E Good, Sara Murphy, Angela Best, Ellen L. Mintz, Silvia Penuela, Ian Greenwood, Machado RF, Avril V Somlyo , Leigh A. Swayne, Richard Minshall, Brant E Isakson. Interaction Between Pannexin 1 and Caveolin-1 in Smooth Muscle Can Regulate Blood Pressure. Arterio Thromb Vascular Biol. 38(9):2065-2078; 2018. PMID: 30026274

Trond Aasen*, Scott R. Johnstone*, Laia Vidal-Brime, K. Sabrina Lynn and Michael Koval*. Connexins: synthesis, post-translational modifications and trafficking in health and disease. Int J Mol Sci. 26:19(5). Pii E1296; 2018. PMID: 29701678

  • *corresponding author

Sara Crespo Yanguas, Joost Willebrords, Scott R. Johnstone, Michaël Maes, Elke Decrock, Marijke De Bock, Luc Leybaert, Bruno Cogliati, Mathieu Vinken. Pannexin1 as mediator of inflammation and cell death. Biochem Bioph Act Mol Cell Res. 1864(1):51-61; 2017. PMID: 27741412

Alexander W. Lohman, Igor Leskov, Joshua Butcher, Scott Johnstone, Tara A. Stokes, Leon J. DeLalio, Angela K. Best, Silvia Peñuela, Norbert Leitinger, Kodi S. Ravichandran, Karen Stokes, and Brant Isakson. Pannexin 1 channels regulate leukocyte emigration through the venous endothelium during acute inflammation. Nat. Comm. 6:7965; 2015. PMID: 26242575

Adam C. Straub, Alexander W. Lohman, Marie Billaud, Scott R. Johnstone, Scott T. Dwyer, Monica Y. Lee, Pamela Schoppee-Bortz, Angela K. Best, Linda Columbus, Benjamin Gaston and Brant E Isakson. Endothelial cell expression of haemoglobin α regulates nitric oxide signalling. Nature. 491:473-477; 2012. PMID: 23123858

  • Commentary: Nitric oxide caught in traffic. Nature. 491:344-345; 2012

Scott R. Johnstone, Brett Kronke, Adam C. Straub, Angela K. Best, Clarence A. Dunn, Leslie A. Mitchell, Yelena Peskova, Robert K. Nakomoto, Michael Koval, Paul D. Lampe, Linda Columbus and Brant E. Isakson.  MAPK phosphorylation of connexin 43 promotes binding of cyclin E and smooth muscle cell proliferation. Circ Res. 111:201-211; 2012. PMID: 22652908

  • Commentary on: Cx43 phosphorylation and VSMC proliferation 111 (2); 2012