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Dr. Johnstone's Publications

For a more complete list of publications, visit the following publication sites: ResearchGate or ORCiD

Yang Yang, Leon Delalio, Angela K. Best, Edgar Maccal, Daniela Begandt, Chen-Hsuin Lee, Jenna Milstein, Iona Donnelly, Ashley M. Miller Martin McBride, Xiaohong H. Shu, Michael Koval, Brant E. Isakson and Scott R. Johnstone. Endothelial Pannexin 1 Channels Control Inflammation by Regulating Intracellular Calcium. The J. of Immunol. 2020 Jun 1;204(11):2995-3007. PMID 32312847

  • Commentary by Juan C Sanchez Arias et al. PANX1 in inflammation heats up: New mechanistic insights with implications for injury and infection. Cell Calcium 2020 Jul 13;90:102253. PMID: 32688074

Leigh Anne Swayne, Scott R Johnstone, Chen Seng Ng, Juan C Sanchez-Arias, Miranda E Good, Silvia Penuela, Alexander W Lohman, Abigail G Wolpe, Victor E Laubach, Michael Koval, Brant E Isakson. Consideration of Pannexin 1 channels in COVID-19 pathology and treatment. Am J Physiol Lung Cell Mol Physiol. 2020 Jul 1;319(1):L121-L125. PMID: 32519892

Leon J DeLalio, Ester Masati, Suresh Mendu, Claire A Ruddiman, Yang Yang, Scott R Johnstone, Jenna A. Milstein, T.C. Stevenson Keller IV, Rachel B Weaver, Nick A. Guagliardo, Angela K Best, Kodi Ravichandran, Douglas A Bayliss, Maria Luisa S. Sequeira-Lopez, Swapnil N. Sonkusare, Bimal Desai, Paula Q. Barrett, Thu H. Le, Ariel R Gomez, and Brant E Isakson. Pannexin 1 channels in renin-expressing cells regulate renin secretion and blood pressure homeostasis. Kindey Int. 2020;S0085-2538(20)30543-3. doi: 10.1016/j.kint.2020.04.041

  • Commentary by Francois Alhenc-Gelas. A new channel for the control of renin secretion in juxtaglomerular cells. Kidney Int. 2020 Sep;98(3):543-545. PMID: 32828234

Matteo Ottolini, Kwangseok Hong, Eric L. Cope, Zdravka Daneva, Leon J. DeLalio, Jennifer D. Sokolowski, Corina Marziano, Nhiem Y. Nguyen, Joachim Altschmied, Judith Haendeler, Scott R. Johnstone, Mohammad Y. Kalani, Min S. Park, Rakesh P. Patel, Wolfgang Liedtke, Brant E. Isakson, Swapnil K. Sonkusare.  Local Peroxynitrite Impairs Endothelial TRPV4 Channels and Elevates Blood Pressure in Obesity. Circulation 2020 Apr 21;141(16):1318-1333. PMID: 32008372

Leon J. DeLalio, Marie Billaud, Claire A. Ruddiman, Scott R. Johnstone, Joshua T. Butcher, A G. Wolpe, X Jin, T.C. Steven Keller, T. Riviera, Miranda E. Good, Angela K. Best, Alexander W. Lohman, Silvia Penuela, Roger J. Thompson, Paul D. Lampe, Mark Y. Yeager and Brant E. Isakson. Constitutive SRC-mediated phosphorylation of pannexin 1 at tyrosine 198 occurs at the plasma membrane. J Biol Chem. 26;294(17):6940-6956; 2019. PMID: 30814251.

Leon J. DeLalio, Alexander S. Keller, Jiwang Chen, Andrew K.J. Boyce, Mykhaylo Artamonov, Henry R. Askew-Page, T.C. Steven Keller 4th, Scott R. Johnstone, Rachel B. Weaver, Miranda E Good, Sara Murphy, Angela Best, Ellen L. Mintz, Silvia Penuela, Ian Greenwood, Machado RF, Avril V Somlyo , Leigh A. Swayne, Richard Minshall, Brant E Isakson. Interaction Between Pannexin 1 and Caveolin-1 in Smooth Muscle Can Regulate Blood Pressure. Arterio Thromb Vascular Biol. 38(9):2065-2078; 2018. PMID: 30026274

Trond Aasen*, Scott R. Johnstone*, Laia Vidal-Brime, K. Sabrina Lynn and Michael Koval*. Connexins: synthesis, post-translational modifications and trafficking in health and disease. Int J Mol Sci. 26:19(5). Pii E1296; 2018. PMID: 29701678

  • *corresponding author

Sara Crespo Yanguas, Joost Willebrords, Scott R. Johnstone, Michaël Maes, Elke Decrock, Marijke De Bock, Luc Leybaert, Bruno Cogliati, Mathieu Vinken. Pannexin1 as mediator of inflammation and cell death. Biochem Bioph Act Mol Cell Res. 1864(1):51-61; 2017. PMID: 27741412

Alexander W. Lohman, Igor Leskov, Joshua Butcher, Scott Johnstone, Tara A. Stokes, Leon J. DeLalio, Angela K. Best, Silvia Peñuela, Norbert Leitinger, Kodi S. Ravichandran, Karen Stokes, and Brant Isakson. Pannexin 1 channels regulate leukocyte emigration through the venous endothelium during acute inflammation. Nat. Comm. 6:7965; 2015. PMID: 26242575

Adam C. Straub, Alexander W. Lohman, Marie Billaud, Scott R. Johnstone, Scott T. Dwyer, Monica Y. Lee, Pamela Schoppee-Bortz, Angela K. Best, Linda Columbus, Benjamin Gaston and Brant E Isakson. Endothelial cell expression of haemoglobin α regulates nitric oxide signalling. Nature. 491:473-477; 2012. PMID: 23123858

  • Commentary: Nitric oxide caught in traffic. Nature. 491:344-345; 2012

Scott R. Johnstone, Brett Kronke, Adam C. Straub, Angela K. Best, Clarence A. Dunn, Leslie A. Mitchell, Yelena Peskova, Robert K. Nakomoto, Michael Koval, Paul D. Lampe, Linda Columbus and Brant E. Isakson.  MAPK phosphorylation of connexin 43 promotes binding of cyclin E and smooth muscle cell proliferation. Circ Res. 111:201-211; 2012. PMID: 22652908

  • Commentary on: Cx43 phosphorylation and VSMC proliferation 111 (2); 2012