DaeYong Lee, Ph.D.
“Biomaterials can help improve anti-cancer effects while minimizing adverse impacts. By testing therapeutic responses in various types of cancers, we can hopefully identify a novel technology that is applicable in the clinic.”
Developing Novel Biomaterials for Cancer Immunotherapy
How can biomaterials re-educate immune cells for cancer immunotherapy?
Dr. Lee's research focuses on developing novel biomaterials to aid in improving the current immunotherapy efficacy or to themselves generate antitumor immune responses and understanding therapeutic mechanisms in the setting of biomaterial treatments. Several factors within tumor microenvironments make immune cells ‘exhausted’, thus reducing therapeutic potency of immunotherapy. Dr. Lee seeks to develop novel biomaterials that can ‘re-educate’ immune cells within tumor microenvironments and understand how biomaterials increase immunotherapy efficacy in various tumor models.
- Assistant Professor, Fralin Biomedical Research Institute at VTC
- Assistant Professor, Department of Biomedical Engineering and Mechanics, College of Engineering
D.Y. Lee et al. (2024) ‘Synthetic cationic helical polypeptides for the stimulation of antitumour innate immune pathways in antigen presenting cells’. Nature Biomedical Engineering.
D.Y. Lee et al. (2023) ‘Engineering nanomaterial physical characteristics for cancer immunotherapy’. Nature Reviews Bioengineering.
Y. Wang, W. Deng, D.Y. Lee+ (Co-first author) et al. (2023) ‘Age-associated disparity in phagocytic clearance affects the efficacy of cancer nanotherapeutics’. Nature Nanotechnology.
Y. Lu, K. Huntoon, D.Y. Lee+ (Co-first author) et al. (2022) ‘Immunological conversion of solid tumours using a bispecific nanobioconjugate for cancer immunotherapy’. Nature Nanotechnology.
D.Y. Lee et al. (2021) ‘Harnessing innate immunity using biomaterials for cancer immunotherapy’. Advanced Materials.
D.Y. Lee et al. (2019) ‘A helical polypeptide-based potassium ionophore induces endoplasmic reticulum stress-mediated apoptosis by perturbing ion homeostasis’. Advanced Science.
University of Texas MD Anderson Cancer Center, Postdoctoral fellow, Department of Neurosurgery and Brain Tumor Center
Korea Advanced Institute of Science and Technology (KAIST), Daejeon, South Korea, Postdoctoral fellow, Department of Chemical and Biomolecular Engineering
- Ph.D., Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, South Korea
- M.S., Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, South Korea
- B.S., Department of Polymer Engineering, Inha University
- Poster presentation award, Leading Edge of Cancer Research Symposium, University of Texas MD Anderson Cancer Center, 2023
- American Association for Cancer Research (AACR)-Sygnature Discovery Scholar-in-Award, 2023
- Top 5 Research Achievement in the Field of Biotechnology in South Korea, BRIC, 2019
- Postdoctoral Fellowship, National Research Foundation in Korea, 2018-2019
- Poster presentation award, The Korean Society for Biomaterials, 2014
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Cancer researcher wants to make treatment better, more accessible , article Date: Sep 20, 2024