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Dr. Pfleger's Publications

For a more complete list of publications, visit Google Scholar or PubMed

Stevens SA, Gonzalez Aguiar MK, Toro AL, Yerlikaya EI, Sunilkumar S, VanCleave AM, Pfleger J, Bradley EA, Kimball SR, Dennis MD. PERK/ATF4-dependent expression of the stress response protein REDD1 promotes proinflammatory cytokine expression in the heart of obese mice. Am J Physiol Endocrinol Metab. 2023 Jan 1;324(1):E62-E72. doi: 10.1152/ajpendo.00238.2022. Epub 2022 Nov 16. PMID: 36383638; PMCID: PMC9870577.

Pfleger J. Measurements of Mitochondrial Respiration in Intact Cells, Permeabilized Cells, and Isolated Tissue Mitochondria Using the Seahorse XF Analyzer. Methods Mol Biol. 2022;2497:185-206. doi: 10.1007/978-1-0716-2309-1_12. PMID: 35771443.

Pfleger J. Measurements of mitochondrial respiration in intact cells, permeabilized cells, and isolated tissue mitochondria using the Seahorse XF Analyzer. Methods in Molecular Biology- Mitochondria Methods and Protocols Edition. Springer Nature. 2021. Invited Book Chapter- In Press.

Bledzka KM, Manaserh IH, Grondolsky J, Pfleger J, Roy R, Gao E, Chuprun JK, Koch WJ, Schumacher SM. A peptide of the amino-terminus of GRK2 induces hypertrophy and yet elicits cardioprotection after pressure overload; J Mol Cell Cardiol. 2021 Feb 4;154:137-153. PMID: 33548241

Heui Jeon Y, He M, Austin J, Shin H, Pfleger J, Abdellatif M. Adiponectin enhances the bioenergetics of cardiac myocytes via an AMPK- and succinate dehydrogenasedependent mechanism; Cell Signal. 2020 Dec 1;78:109866. PMID: 33271223

Pfleger J*, Coleman RC, Ibetti J, Roy R, Kyriazis ID, Gao E, Drosatos K, Koch WJ*. Genomic binding patterns of forkhead box protein O1 reveal its unique role in cardiac hypertrophy; Circulation. 2020 September 1;142:882-898. PMID: 32640834 
*Corresponding Author

Lieu M, Traynham CJ, De Lucia C, Pfleger J, Piedepalumbo M, Roy R, Petovic J, Landesberg GP, Forrester S, Hoffman M, Grisanti L, Yuan A, Gao E, Drosatos K, Eguchi S, Scalia R, Tilley DG, Koch WJ. Loss of dynamic regulation of G proteincoupled receptor kinase 2 by nitric oxide leads to cardiovascular dysfunction with aging; Am J Physiol Heart Circ Physiol. 2020 May 1;318(5):H1162-H1175. PMID: 32216616

Wallner M, Eaton DM, Berretta RM, Liesinger L, Schittmayer M, Gindlhuber J, Wu J, Jeong MY, Lin YH, Borghetti G, Baker ST, Zhao H, Pfleger J, Blass S, Rainer PP, Von Lewinski D, Bugger H, Mohsin S, Graier WF, Zirlik A, McKinsey TA, Birner- Gruenberger R, Wolfson MR, Houser SR. HDAC inhibition improves cardiopulmonary function in a model with features of heart failure with preserved ejection fraction; Sci Transl Med. 2020 Jan 8;12(25). PMID: 31915304

Pfleger J*, Choi S*, Heui Jeon Y, Yang Z, He M, Shin H, Sayed D, Astrof S, Abdellatif M. Oxoglutarate dehydrogenase and acetyl-CoA acyltransferase 2 selectively associate with H2A.Z-occupied promoters and are required for histone modifications; Biochim Biophys Acta Gene Regul Mech. 2019 Oct;1862(10):194436. PMID: 31682939  
*Equal Contribution

Vagnozzi RJ, Pfleger J, Sadayappan S. Basic Cardiovascular Sciences Scientific Sessions 2019: Integrative Approaches to Complex Cardiovascular Diseases; Circ Res. 2019 September;125:924-931. PMID: 31647770

Pfleger J, Gresham K, Koch WJ. G-protein-coupled receptor kinases in the heart: therapeutic targets; Nat Rev Cardiol. 2019 June;16;612-622. PMID: 31186538

Woodall BP, Gresham KS, Woodall MA, Valenti MC, Cannavo A, Pfleger J, Drosatos K, Koch WJ. Alteration of Myocardial GRK2 Produces a Global Metabolic Phenotype. JCI Insight. 2019 Apr 4;5. PMID 30946029

Pfleger J, Gross P, Johnson J, Gao E, Houser SR, Koch WJ; G protein-coupled receptor kinase 2 contributed to impaired fatty acid metabolism in the failing heart; J Mol Cell Cardiol. 2018 Oct;123;108-117. PMID: 30171848

Shin H, He M, Yang Z, Jeon YH, Pfleger J, Sayed D, Abdellatif M; Transcriptional regulation mediated by H2A.Z via ANP32e-dependent inhibition of protein phosphatase 2A; Biochim Biophys Acta Gene Regul Mech. 2018 May;1861(5):481-496. PMID: 29524612

Pfleger J, He M, Abdellatif M; Mitochondrial complex II is a source of the reserve respiratory capacity that is regulated by metabolic sensors and promotes cell survival; Cell Death Dis. 2015 Jul 30;6;e1835. PMID: 26225774

Ikeda Y, Shirakabe A, Maejima Y, Zhai P, Sciarretta S, Toli J, Nomura M, Mihara K, Egashira K, Ohishi M, Abdellatif M, Sadoshima J; Endogenous Drp1 Mediates Mitochondrial Autophagy and Protects the Heart Against Energy Stress; Circ Res. 2015 Jan 16;116(2):264-78. PMID: 25332205

Sayed D, He M, Yang Z, Pfleger J, Abdellatif M; Acute targeting of general transcription factor IIB restricts cardiac hypertrophy via selective inhibition of gene transcription; Circ Heart Fail. 2015 Jan;8(1):138-48. PMID: 25398966

Han M, Toli J, Abdellatif M; MicroRNAs in the cardiovascular system; Curr Opin Cardiol. 2011 May; 26(3):181-9. PMID: 21464712