Virginia Tech®home

Dr. Sheng's Publications

For a more complete list of publications, visit the following publication sites: PubMed

Graybill PM, Bollineni RK, Sheng Z, Davalos RV, Mirzaeifar R. A constriction channel analysis of astrocytoma stiffness and disease progression. Biomicrofluidics. 2021 Mar 16;15(2):024103. doi: 10.1063/5.0040283. PMID: 33763160; PMCID: PMC7968935.

Sheng KL, Kang L, Pridham KJ, Dunkenberger LE, Sheng Z, Varghese RT. An integrated approach to biomarker discovery reveals gene signatures highly predictive of cancer progression. Sci Rep. 2020 Dec 4;10(1):21246. doi: 10.1038/s41598-020-78126-3. PMID: 33277589; PMCID: PMC7718261.

Sheng Z. Connexin 43 peptidic medicine for glioblastoma stem cells. EBioMedicine. 2021 Feb;64:103205. doi: 10.1016/j.ebiom.2020.103205. Epub 2021 Jan 23. PMID: 33493796; PMCID: PMC7823208.

Pridham KJ, Shah F, Sheng KL, Guo S, Min L, Kanabur P, Lamouille S, Lewis G, Morales M, Jourdan J, Grek CL, Ghatnekar GG, Varghese R, Kelly, DF, Gourdie RG, Sheng Z. Connexin 43 confers chemoresistance through activating PI3K. BioRxiv. 2020. Preprint DOI: 10.1101/2020.10.14.339275.

Solares M, Jonaid GM, Luqiu W, Liang, Y, Evans M, Dearnaley W, Sheng Z, Kelly D. Microchip-based structure determination of disease-relevant p53. Analytical Chemistry. 2020. In press.

Roberts R, Smyth J, Will J, Roberts P, Grek C, Ghatnekar G, Sheng Z, Gourdie R, Lamouille S, and Foster J. Development of PLGA nanoparticles for sustained release of a Connexin43 mimetic peptide to target glioblastoma cells. Materials Science & Engineering C. 2020. 108: 110191. DOI:

Alden NA, Varano AC, Dearnaley WJ, Solares MJ, Luqiu WY, Liang Y, Sheng Z, McDonald SM, Damiano J, McConnell J, Dukes M, and Kelly DF. Cryo-EM-on-a-Chip: Custom-designed Substrates for the 3D Analysis of Macromolecules. SMALL. 2019. 15(21):e1900918. DOI: 10.1002/smll.201900918. PMID: 30963664.

Ivey JW, Wasson EM, Alinezhad E, Kanitkar A, Sheng Z, DavalosRV, Verbridge SS. Characterization of ablation thresholds for 3D-cultured patient-derived glioma stem cells in response to high-frequency irreversible electroporation. Research. 2019. 2019 (1):8081315. DOI: 10.34133/2019/8081315

Sheng KL, Pridham KJ, Sheng Z, Lamouille S, Varghese RT. (2019). Functional Blockade of the Small GTPase RAN Inhibits Glioblastoma Viability. Frontiers in Oncology 8: 662.

Liang Y, Dearnaley WJ, Alden NA, Solares MJ, Gilmore BL, Pridham KJ, Varano AC, Sheng Z, Alli E, Kelly DF. (2019). Correcting Errors in the BRCA1 Warning System. DNA Repair 73: 120-128.

Varghese RT, Young S, Pham LC, Liang Y, Pridham KJ, Guo S, Murphy SF, Kelly DF, and Sheng Z. (2018). Casein Kinase 1 Epsilon Regulates Glioblastoma Cell Survival. Scientific Reports 8(1).

Guo S, Pridham KJ, Virbasius CM, He B, Zhang L, Varmark H, Green MR, Sheng Z. (2018). A large-scale RNA interference screen identifies genes that regulate autophagy at different stages. Scientific Reports 8(1).

Pridham KJ, Varghese RT, Sheng Z. (2017). The Role of Class IA Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunits in Glioblastoma. Frontiers in Oncology 7(312).

Liang Y, Dearnaley WJ, Varano AC, Winton CE, Gilmore BL, Alden NA, Sheng Z, Kelly DF. (2017). Structural analysis of BRCA1 reveals modification hotspot. Science Advances 3(9).

Pridham KJ, Le L, Guo S, Varghese RT, Algino S, Liang Y, Fajardin R, Rodgers CM, Simonds GR, Kelly DF, Sheng Z. (2017). PIK3CB/p110β is a Selective Survival Factor for Glioblastoma. Neuro-Oncology.

Guo S, Pridham KJ, Sheng Z. (2016). Detecting Autophagy and Autophagy Flux in Chronic Myeloid Leukemia Cells Using a Cyto-ID Fluorescence Spectrophotometric Assay. In: Methods in Molecular Biology. (pp. 95-109):

Varghese RT, Lian Y, Guan T, Franck CT, Kelly DF, Sheng Z. (2016). Survival kinase genes present prognostic significance in glioblastoma. Oncotarget.

Murphy SF, Varghese RT, Lamouille S, Guo S, Pridham KJ, Kanabur P, Osimani AM, Sharma S, Jourdan J, Rodgers CM, Simonds GR, Gourdie RG, Sheng Z. (2016). Connexin 43 Inhibition Sensitizes Chemoresistant Glioblastoma Cells to Temozolomide. Cancer Research 76(1): 139-49.

Gilmore BL, Winton CE, Demmert AC, Tanner JR, Bowman S, Karageorge V, Patel K, Sheng Z, Kelly DF. (2015). A Molecular Toolkit to Visualize Native Protein Assemblies in the Context of Human Disease. Scientific Reports 5.

Li T, Murphy S, Kiselev B, Bakshi KS, Zhang J, Eltahir A, Zhang Y, Chen Y, Zhu J, Davis RM, Madsen LA, Morris JR, Karolyi DR, LaConte SM, Sheng Z, Dorn HC. (2015). A New Interleukin-13 Amino-Coated Gadolinium Metallofullerene Nanoparticle for Targeted MRI Detection of Glioblastoma Tumor Cells. Journal of the American Chemical Society 137(24): 7881-8.

Pohlmann ES, Patel K, Guo S, Dukes MJ, Sheng Z, Kelly DF. (2015). Real-time visualization of nanoparticles interacting with glioblastoma stem cells. Nano Letters 15(4): 2329-35.

Guo S, Liang Y, Murphy SF, Huang A, Shen H, Kelly DF, Sobrado P, Sheng Z. (2015). A rapid and high content assay that measures cyto-ID-stained autophagic compartments and estimates autophagy flux with potential clinical applications. Autophagy 25.

Ma L, Shan Y, Bai R, Xue L, Eide CA, Ou J, Zhu LJ, Hutchinson L, Cerny J, Khoury HJ, Sheng Z, Druker BJ, Li S, Green MR. (2014). A therapeutically targetable mechanism of BCR-ABL-independent imatinib resistance in chronic myeloid leukemia. Science Translational Medicine 6(252).

Sheng Z, Murphy SF, Guo S, Green MR. (2014). A diphtheria toxin negative selection in RNA interference screening. In: Wajapeyee N (Ed.), Cancer Genomics and Proteomics (Methods in Molecular Biology). (pp. 59-72):New York City: Humana Press (Springer).

Jang HN, Lee M, Loh TJ, Choi S-W, Oh HK, Moon H, Cho S, Hong S-E, Kim DH, Sheng Z, Green MR, Park D, Zheng X, Shen H. (2014). Exon 9 skipping of apoptotic caspase-2 pre-mRNA is promoted by SRSF3 through interaction with exon 8. Biochimica et Biophysica Acta 1839(1): 25-32.

Oh HK, Lee E, Jang HN, Lee J, Moon H, Sheng Z, Jun Y, Loh TJ, Cho S, Zhou J, Green MR, Zheng X, Shen H. (2013). hnRNP A1 contacts exon 5 to promote exon 6 inclusion of apoptotic Fas gene. Apoptosis 18(7): 825-35.

Den RB, Kamrava M, Sheng Z, Werner-Wasik M, Dougherty E, Martinucchi M, Lawrence YR, Hegarty S, Hyslop T, Andrews DW, Glass J, Friedman DP, Green MR, Camphausen K, Dicker AP. (2013). A phase I study of the combination of sorafenib with temozolomide and radiation therapy for the treatment of primary and recurrent high-grade gliomas. Int. J Radiat. Oncol. Biol. Phys.

Zhang H, Peng C, Hu Y, Li H, Sheng Z, Chen Y, Sullivan C, Cerny J, Hutchinson L, Higgins A, Miron P, Zhang X, Brehm MA, Li D, Green MR, Li S. (2012). The Blk pathway functions as a tumor suppressor in chronic myeloid leukemia stem cells. Nat Genet.

Sheng Z, Ma L, Green MR. (2011). The BCR-ABL oncoprotein suppresses autophagy through transcriptional regulation of mTOR expression by activating transcription factor 5. Blood 118(10): 2840-2848.

Sheng Z, Evans KS, and Green MR. (2010). An activating transcription factor 5-mediated survival pathway as a target for cancer therapy. Oncotarget 1(6): 457-460.

Sheng Z, Li L, Zhu LH, Smith TW, Demers A, Ross AH, Moser RP, and Green MR. (2010). A genome-wide RNA interference screen reveals an essential CREB3l2-ATF5-MCL1survival pathway in malignant glioma with therapeutic implications. Nat. Med 16: 671-677.

Sheng Z, Wang S, and Green MR. (2009). Transcription and signaling pathways involved in BCR-ABL-mediated misregulation of 24p3 and 24p3R. EMBO J 28: 866-876.