Virginia Tech®home

Dr. Smyth's Publications

For a more complete list of publications, visit the following publication sites: PubMed

Rai P, Chuong C, LeRoith T, Smyth JW, Panov J, Levi M, Kehn-Hall K, Duggal NK, Lucarelli JW. Adenovirus transduction to express human ACE2 causes obesity-specific morbidity in mice, impeding studies on the effect of host nutritional status on SARS-CoV-2 pathogenesis. Virology. 2021 Nov;563:98-106. doi: 10.1016/j.virol.2021.08.014. Epub 2021 Sep 3. PMID: 34509029; PMCID: PMC8414371.

Bandara AB, Drake JC, James CC, Smyth JW, Brown DA. Complex I protein NDUFS2 is vital for growth, ROS generation, membrane integrity, apoptosis, and mitochondrial energetics. Mitochondrion. 2021 May;58:160-168. doi: 10.1016/j.mito.2021.03.003. Epub 2021 Mar 18. PMID: 33744462; PMCID: PMC8113094.

Grieco JP, Allen ME, Perry JB, Wang Y, Song Y, Rohani A, Compton SLE, Smyth JW, Swami NS, Brown DA, Schmelz EM. Progression-Mediated Changes in Mitochondrial Morphology Promotes Adaptation to Hypoxic Peritoneal Conditions in Serous Ovarian Cancer. Front Oncol. 2021 Jan 13;10:600113. doi: 10.3389/fonc.2020.600113. PMID: 33520711; PMCID: PMC7838066.

King DR, Padget RL, Perry J, Hoeker G, Smyth JW, Brown DA, Poelzing S. Elevated perfusate [Na+] increases contractile dysfunction during ischemia and reperfusion. Sci Rep. 2020 Oct 14;10(1):17289. doi: 10.1038/s41598-020-74069-x. PMID: 33057157; PMCID: PMC7560862.

Dunn HP, Teo KZ, Smyth JW, Weerasinghe LS, Costello J, Pampapathi P, Keay L, Green T, Vukasovic M, Bruce BB, Newman NJ, Biousse V, White AJ, McCluskey P, Fraser CL. Using non-mydriatic fundus photography to detect fundus pathology in Australian metropolitan emergency departments: A prospective prevalence and diagnostic accuracy study. Emerg Med Australas. 2021 Apr;33(2):302-309. doi: 10.1111/1742-6723.13619. Epub 2020 Sep 17. PMID: 32945132.

Hoeker GS, James CC, Tegge AN, Gourdie RG, Smyth JW, Poelzing S. Attenuating loss of cardiac conduction during no-flow ischemia through changes in perfusate sodium and calcium. Am J Physiol Heart Circ Physiol. 2020 Aug 1;319(2):H396-H409. doi: 10.1152/ajpheart.00112.2020. Epub 2020 Jul 17. PMID: 32678707; PMCID: PMC7473923.

Calhoun PJ, Phan AV, Taylor JD, James CC, Padget RL, Zeitz MJ, Smyth JW. Adenovirus targets transcriptional and posttranslational mechanisms to limit gap junction function. FASEB J. 2020 Jul;34(7):9694-9712. doi: 10.1096/fj.202000667R. Epub 2020 Jun 2. PMID: 32485054; PMCID: PMC7501180.

Zeitz MJ, Smyth JW. Translating Translation to Mechanisms of Cardiac Hypertrophy. J Cardiovasc Dev Dis. 2020 Mar 10;7(1):9. doi: 10.3390/jcdd7010009. PMID: 32164190; PMCID: PMC7151157.

Roberts R, Smyth JW, Will J, Roberts P, Grek CL, Ghatnekar GS, Sheng Z, Gourdie RG, Lamouille S, Foster EJ. Development of PLGA nanoparticles for sustained release of a connexin43 mimetic peptide to target glioblastoma cells. Mater Sci Eng C Mater Biol Appl. 2020 Mar;108:110191. doi: 10.1016/j.msec.2019.110191. Epub 2019 Sep 12. PMID: 31923988.

Doyle CY, Ruiz JM, Taylor DJ, Smyth JW, Flores M, Dietch JR, Ahn C, Allison M, Smith TW, Uchino BN. Associations Between Objective Sleep and Ambulatory Blood Pressure in a Community Sample. Psychosom Med. 2019 Jul/Aug;81(6):545-556. doi: 10.1097/PSY.0000000000000711. PMID: 31083055; PMCID: PMC6607429.

Zeitz MJ, Calhoun PJ, James CC, Taetzsch T, George KK, Robel S, Valdez G, Smyth JW. Dynamic UTR Usage Regulates Alternative Translation to Modulate Gap Junction Formation during Stress and Aging. Cell Rep. 2019 May 28;27(9):2737-2747.e5. doi: 10.1016/j.celrep.2019.04.114. PMID: 31141695; PMCID: PMC6857847.

Payne LB, Zhao H, James CC, Darden J, McGuire D, Taylor S, Smyth JW, Chappell JC. The pericyte microenvironment during vascular development. Microcirculation. 2019 Nov;26(8):e12554. doi: 10.1111/micc.12554. Epub 2019 May 27. PMID: 31066166; PMCID: PMC6834874.

Payne LB, Zhao H, James CC, Darden J, McGuire D, Taylor S, Smyth JW, Chappell JC. The pericyte microenvironment during vascular development. Microcirculation. 2019 Nov;26(8):e12554. doi: 10.1111/micc.12554. Epub 2019 May 27. PMID: 31066166; PMCID: PMC6834874.

George SA, Hoeker G, Calhoun PJ, Entz M 2nd, Raisch TB, King DR, Khan M, Baker C, Gourdie RG, Smyth JW, Nielsen MS, Poelzing S. Modulating cardiac conduction during metabolic ischemia with perfusate sodium and calcium in guinea pig hearts. Am J Physiol Heart Circ Physiol. 2019 Apr 1;316(4):H849-H861. doi: 10.1152/ajpheart.00083.2018. Epub 2019 Feb 1. PMID: 30707595; PMCID: PMC6483020.

James CC, Smyth JW. Alternative mechanisms of translation initiation: An emerging dynamic regulator of the proteome in health and disease. Life Sci. 2018 Nov 1;212:138-144. doi: 10.1016/j.lfs.2018.09.054. Epub 2018 Oct 2. PMID: 30290184; PMCID: PMC6345546.

Veeraraghavan R, Hoeker GS, Alvarez-Laviada A, Hoagland D, Wan X, King DR, Sanchez-Alonso J, Chen C, Jourdan J, Isom LL, Deschenes I, Smyth JW, Gorelik J, Poelzing S, Gourdie RG. The adhesion function of the sodium channel beta subunit (β1) contributes to cardiac action potential propagation. Elife. 2018 Aug 14;7:e37610. doi: 10.7554/eLife.37610. PMID: 30106376; PMCID: PMC6122953.

James CC, Zeitz MJ, Calhoun PJ, Lamouille S, Smyth JW. (2018). Altered translation initiation of Gja1 limits gap junction formation during epithelial-mesenchymal transition. Molecular Biology of the Cell 29(7): 773-880.

Smyth JW, Zhang SS, Sanchez JM, Lamouille S, Vogan JM, Hesketh GG, Hong T, Tomaselli GF, Shaw RM. (2014). A 14-3-3 mode-1 binding motif initiates gap junction internalization during acute cardiac ischemia. Traffic 15(6): 684-699.

Smyth JW, Shaw RM. (2013). Autoregulation of connexin43 gap junction formation by internally translated isoforms. Cell Reports.

Hong TT, Smyth JW, Chu KY, Vogan JM, Fong TS, Jensen BC, Fang K, Halushka MK, Russell SD, Colecraft H, Hoopes CW, Ocorr K, Chi NC, Shaw RM. (2012). BIN1 is reduced and Cav1.2 trafficking is impaired in human failing cardiomyocytes. Heart Rhythm 9(5).

Horiuchi D, Kusdra L, Huskey NE, Chandriani S, Lenburg ME, Gonzalez-Angulo AM, Creasman KJ, Bazarov AV, Smyth JW, Davis SE, Yaswen P, Mills GB, Esserman LJ, Goga A. (2012). MYC pathway activation in triple-negative breast cancer is synthetic lethal with CDK inhibition. The Journal of Experimental Medicine 209(4): 679-96.

Smyth JW, Vogan JM, Buch PJ, Zhang SS, Fong TS, Hong TT, Shaw RM. (2012). Actin cytoskeleton rest stops regulate anterograde traffic of connexin 43 vesicles to the plasma membrane. Circulation Research 110(7).

Smyth JW, Shaw RM. (2012). The gap junction life cycle. Heart Rhythm 9(1): 151-3.

Lamouille S, Connonlly E, Smyth JW, Akhurst RJ, Derynck R. (2012). TGF-β-induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion. Journal of Cell Science 125: 1259-73.

Smyth JW, Shaw RM. (2012). Visualizing cardiac ion channel trafficking pathways. Methods in Enzymology 505: 187-202.

Zhang SS, Kim KH, Rosen A, Smyth JW, Sakuma R...Shaw RM, Hui CC, Bruneau BG, Backx PH. (2011). Iroquois homeobox gene 3 establishes fast conduction in the cardiac His-Purkinje network. Proceedings of the National Academy of Sciences 108(33): 13576-81.

Nordstrom SM, Holliday BA, Sos BC, Smyth JW, Levy RE, Dukes JW, Lord ST, Weiss EJ. (2010). Increased thrombosis susceptibility and altered fibrin formation in STAT5-deficient mice. Blood 116(25): 5724-33.

Smyth JW, Shaw RM. (2010). Forward trafficking of ion channels: what the clinician needs to know. Heart Rhythm 7(8).

Smyth JW, Hong TTH, Gao D, Vogan J, Jensen B, Fong T, Simpson P, Stainier D, Chi N, Shaw RM. (2010). Limited forward trafficking of connexin 43 reduces cell-cell coupling in stressed human and mouse myocardium. The Journal of Clinical Investigation 120(1): 87-9.

Saxena A, Fish JE, White MD, Yu S, Smyth JW, Shaw RM, DiMaio JM, Srivastava D. (2008). Stromal cell-derived factor-1α is cardioprotective after myocardial infarction. Circulation 117: 2224-2231.

Smyth JW, Shaw RM. (2008). Visualizing ion channel dynamics at the plasma membrane. Heart Rhythm 5: S7-11.

. (2005). Treatment of rapidly growing K-BALB and CT26 mouse tumors using Semliki Forest virus and its derived vector. Gene Therapy 12(2): 147-59.

Atkins GJ, Smyth JW, Fleeton MN, Galbraith SE, Sheahan BJ. (2004). Alphaviruses and their derived vectors as anti-tumor agents. Current Cancer Drug Targets 4(7): 597-607.