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Dr. Warren's Publications

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Oka S, Sabry AD, Horiuchi AK, Cawley KM, O’Very SA, Zaitsev MA, Shankar TS, Byun J, Mukai R, Xu X, Torres NS, Kumar A, Yazawa M, Ling J, Taleb I, Saijoh Y, Drakos SG, Sadoshima J, Warren JS. Perm1 regulates cardiac energetics as a downstream target of the histone methyltransferase Smyd1. PloS one. (accepted for publication on June 5, 2020).

Bhat S, Chin A, Shirakabe A, Ikeda Y, Ikeda S, Zhai P, Hsu CP, Sayed D, Abdellatif M, Byun J, Schesing K, Tang F, Tian Y, Babu G, Ralda G, Warren JS, Cho J, Sadoshima J, Oka. Recruitment of RNA Polymerase II to Metabolic Gene Promoters Is Inhibited in the Failing Heart Possibly Through PGC-1α (Peroxisome Proliferator-Activated Receptor-γ Coactivator-1α) Dysregulation. Circ Heart Fail. 2019 Mar;12(3):e005529. PMID:30798619. PMCID: PMC6392084 

Nakamura M, Tong L, Husain S, Zhai P, Warren J.S., Hsu C.P., Matsuda T, Phiel C.J., Cox J.E., Tian B, Li H, Sadoshima J. (2019). Glycogen Synthase Kinase-3α Promotes Fatty Acid Uptake and Lipotoxic Cardiomyopathy. Cell Metab, 7(29), 1119-1134. 

Zaitsev AV, Torres NS, Cawley KM, Sabry AD, Warren JS, Warren M. (2019). Conduction in the Right and Left Ventricle is Differentially Regulated by Protein Kinases and Phosphatases: Implications for Arrhythmogenesis. Am J Physiol Heart Circ Physiol.

Warren JS, Tracy CM, Miller MR, Makaju A, Szulik MW, Oka SI, Yuzyuk TN, Cox JE, Kumar A, Lozier BK, Wang L, Llana JG, Sabry AD, Cawley KM, Barton DW, Han YH, Boudina S, Fiehn O, Tucker HO, Zaitsev AV, Franklin S (2018). Histone methyltransferase Smyd1 regulates mitochondrial energetics in the heart. Proc Natl Acad Sci U S A.

Tracy C, Warren JS, Szulik M, Wang L, Garcia J, Makaju A, Russell K, Miller M, Franklin S (2018). The Smyd Family of Methyltransferases: Role in Cardiac and Skeletal Muscle Physiology and Pathology. Curr Opin Physiol, 1, 140-52.

Warren M, Sciuto KJ, Taylor TG, Garg V, Torres NS, Shibayama J, Spitzer KW, Zaitsev AV (2017). Blockade of CaMKII Depresses Conduction Preferentially in the Right Ventricular Outflow Tract and Promotes Ischemic Ventricular Fibrillation in the Rabbit Heart. Am J Physiol Heart Circ Physiol, ajpheart.00347.2016.

Garg V, Taylor T, Warren M, Venable P, Sciuto K, Shibayama J, Zaitsev A (2015). beta-Adrenergic stimulation and rapid pacing mutually promote heterogeneous electrical failure and ventricular fibrillation in the globally ischemic heart. Am J Physiol Heart Circ Physiol, 308(9), H1155-70.

Venable PW, Sciuto KJ, Warren M, Taylor TG, Garg V, Shibayama J, Zaitsev AV (2015). Mitochondrial depolarization and asystole in the globally ischemic rabbit heart: coordinated response to interventions affecting energy balance. Am J Physiol Heart Circ Physiol, 308(5), H485-99.

Shibayama J, Yuzyuk TN, Cox J, Makaju A, Miller M, Lichter J, Li H, Leavy JD, Franklin S, Zaitsev AV (2015). Metabolic remodeling in moderate synchronous versus dyssynchronous pacing-induced heart failure: integrated metabolomics and proteomics study. PLoS ONE, 10(3), e0118974.

Diakos NA, Selzman CH, Sachse FB, Stehlik J, Kfoury AG, Wever-Pinzon O, Catino A, Alharethi R, Reid BB, Miller DV, Salama M, Zaitsev AV, Shibayama J, Li H, Fang JC, Li DY, Drakos SG (2014). Myocardial atrophy and chronic mechanical unloading of the failing human heart: implications for cardiac assist device-induced myocardial recovery. J Am Coll Cardiol, 64(15), 1602-12.

Taylor TG, Venable PW, Booth A, Garg V, Shibayama J, Zaitsev AV (2013). Does the combination of hyperkalemia and KATP activation determine excitation rate gradient and electrical failure in the globally ischemic fibrillating heart? Am J Physiol Heart Circ Physiol, 305(6), H903-12.

Venable PW, Taylor TG, Sciuto KJ, Zhao J, Shibayama J, Warren M, Spitzer KW, Zaitsev AV (2013). Detection of mitochondrial depolarization/recovery during ischaemia--reperfusion using spectral properties of confocally recorded TMRM fluorescence. J Physiol, 591(11), 2781-94.

Shibayama J, Taylor TG, Venable PW, Rhodes NL, Gil RB, Warren M, Wende AR, Abel ED, Cox J, Spitzer KW, Zaitsev AV (2013). Metabolic determinants of electrical failure in ex-vivo canine model of cardiac arrest: evidence for the protective role of inorganic pyrophosphate. PLoS ONE, 8 (3), e57821.

Taylor TG, Venable PW, Shibayama J, Warren M, Zaitsev AV (2012). Role of KATP channel in electrical depression and asystole during long-duration ventricular fibrillation in ex vivo canine heart. Am J Physiol Heart Circ Physiol, 302(11), H2396-409.

Pandit SV, Kaur K, Zlochiver S, Noujaim SF, Furspan P, Mironov S, Shibayama J, Anumonwo J, Jalife J (2011). Left-to-right ventricular differences in I(KATP) underlie epicardial repolarization gradient during global ischemia. Heart Rhythm, 8(11), 1732-9.

Venable PW, Taylor TG, Shibayama J, Warren M, Zaitsev AV (2010). Complex structure of electrophysiological gradients emerging during long-duration ventricular fibrillation in the canine heart. Am J Physiol Heart Circ Physiol, 299(5), H1405-18.

Warren M, Spitzer KW, Steadman BW, Rees TD, Venable P, Taylor T, Shibayama J, Yan P, Wuskell JP, Loew LM, Zaitsev AV (2010). High-precision recording of the action potential in isolated cardiomyocytes using the near-infrared fluorescent dye di-4-ANBDQBS. Am J Physiol Heart Circ Physiol, 299(4), H1271-81.

Maass K, Shibayama J, Chase SE, Willecke K, Delmar M (2007). C-terminal truncation of connexin43 changes number, size, and localization of cardiac gap junction plaques. Circ Res, 101 (12), 1283-91.

Shibayama J, Gutierrez C, Gonzalez D, Kieken F, Seki A, Carrion JR, Sorgen PL, Taffet SM, Barrio LC, Delmar M (2006). Effect of charge substitutions at residue his-142 on voltage gating of connexin43 channels. Biophys J, 91(11), 4054-63.

Shibayama J, Lewandowski R, Kieken F, Coombs W, Shah S, Sorgen PL, Taffet SM, Delmar M (2006). Identification of a novel peptide that interferes with the chemical regulation of connexin43. Circ Res, 98(11), 1365-72.

Shibayama J, Paznekas W, Seki A, Taffet S, Jabs EW, Delmar M, Musa H (2005). Functional characterization of connexin43 mutations found in patients with oculodentodigital dysplasia. Circ Res, 96(10), e83-91.