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Dr. Yu's Publications

Yu JR, LeRoy G, Bready D, Frenster DF, Saldaña-Meyer R, Jin Y, Descostes N, Stafford JM, Plakantonakis DG, Reinberg D. The H3K36me2 writer-reader dependency in H3K27M-DIPG. BioRxiv (doi: https://doi.org/10.1101/2021.01.06.425580) Science Advances. 2021 (in press, to appear in the issue of July 14th, 2021).

Lee CH*, Yu JR*, Granat J*, Saldaña-Meyer R, Andrade J, LeRoy G, Jin Y, Lund P, Stafford JM, Garcia BA, Ueberheide B, Reinberg D. Automethylation of PRC2 promotes H3K27 methylation and is impaired in H3K27M pediatric glioma. Genes & Development. 2019 Oct 1;33(19-20):1428-1440. *Equal contribution.

LeRoy G, Oksuz O, Descostes N, Aoi Y, Ganai RA, Kara HO, Yu JR, Lee CH, Stafford JM, Shilatifard A, Reinberg D. LEDGF and HDGF2 relieve the nucleosome-induced barrier to transcription in differentiated cells. Science Advances. 2019 Oct 2;5(10):eaay3068. 

Yu JR*, Lee CH*, Oksuz O*, Stafford JM, Reinberg D. PRC2 is high maintenance. Genes & Development. 2019 Aug 1;33(15-16):903-935. (Review) *Equal contribution.

Stafford JM, Lee CH, Voigt P, Descostes N, Saldana-Meyer R, Yu JR, LeRoy G, Oksuz O, Chapman JR, Suarez F, Modrek AS, Bayin S, Plakantonakis DG, Karajannis MA, Snuderl M, Ueberheide B, Reinberg D. Multiple modes of PRC2 inhibition elicit global chromatin alterations in H3K27M pediatric glioma. Science Advances. 2018 Oct 31;4(10):eaau5935.Lee CH, Holder M, Grau D, Saldaña-Meyer R, Yu JR, Ganai RA, Zhang J, Wang M, LeRoy G, Dobenecker MW, Reinberg D, Armache KJ. Distinct stimulatory mechanisms regulate the catalytic activity of Polycomb Repressive Complex 2. Molecular Cell. 2018 Apr 13. pii: S1097-2765(18)30222-3.

Lee CH*, Yu JR*, Kumar S, Jin Y, Hamilton A, Reinberg D. Allosteric activation dictates PRC2 activity independent of its recruitment to chromatin. Molecular Cell. 2018 Apr 13. pii: S1097-2765(18)30223-5. *Equal contribution.

Tai Y, Gallo NB, Wang M, Yu JR, Van Aelst L. Axo-axonic innervation of neocortical pyramidal neurons by GABAergic chandelier cells require AnkryrinG-associated L1CAM. Neuron. 2019 Apr 17;102(2):358-372.e9.

Nakamuta S, Yang YT, Wang CL, Gallo NB, Yu JR, Tai Y, Van Aelst L. Dual role for DOCK7 in tangenital migration of interneuron precursors in the postnatal forebrain. The Journal of Cell Biology. 2017 Dec 4;216(12):4313-4330.

Yu JR, Tai Y, Jin Y, Hammell MC, Wilkinson JE, Roe JS, Vakoc CR, Van Aelst L. TGF-β/Smad signaling through DOCK4 facilitates lung adenocarcinoma metastasis. Genes & Development. 2015 Feb 1;29(3):250-261.