Sharon K. Michelhaugh, Ph.D.

• University of Michigan, Ph.D., Pharmacology (Dissertation: Time-dependent alterations in calmodulin and its mRNAs after acute and repeated, intermittent amphetamine)
• Otterbein College, B.S., Life Science and Chemistry
• Postdoctoral Fellowship, Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, 2000-2001 
• Postdoctoral Fellowship, University of Michigan Substance Abuse Research Center, 1998-2000
  

Wayne State University School of Medicine

• Research Scientist, Department of Neurosurgery, 2016-2019 
• Research Associate, Department of Neurosurgery,  2012-2016 
  
• Assistant Professor-Research, Department of Pharmacology, 2006-2011 
• Assistant Professor-Research, Department of Psychiatry and Behavioral Neurosciences, 2003-2006 
• Research Associate, Department of Psychiatry and Behavioral Neurosciences, 2001-2003 

View Dr. Michelhaugh's ResearchGate profile

Park H, Jin UH, Karki K, Jayaraman A, Allred C, Michelhaugh SK, Mittal S, Chapkin RS, Safe S. Dopamine is an aryl hydrocarbon receptor agonist. Biochem J. 2020 Oct 16;477(19):3899-3910. doi: 10.1042/BCJ20200440. PMID: 32905582

John F, Michelhaugh SK, Barger GR, Mittal S, Juhász C. Depression and tryptophan metabolism in patients with primary brain tumors: Clinical and molecular imaging correlates. Brain Imaging Behav. 2020 Aug 6:10.1007/s11682-020-00305-7. doi: 10.1007/s11682-020-00305-7. Online ahead of print. PMID: 32767048

Jin UH, Michelhaugh SK, Polin LA, Shrestha R, Mittal S, Safe S. Omeprazole Inhibits Glioblastoma Cell Invasion and Tumor Growth. Cancers (Basel). 2020 Jul 28;12(8):2097. doi: 10.3390/cancers12082097. PMID: 32731514

Ou A, Sumrall A, Phuphanich S, Spetzler D, Gatalica Z, Xiu J, Michelhaugh S, Brenner A, Pandey M, Kesari S, Korn WM, Mittal S, Westin J, Heimberger AB. Primary CNS lymphoma commonly expresses immune response biomarkers. Neurooncol Adv. 2020 Jan-Dec;2(1):vdaa018. doi: 10.1093/noajnl/vdaa018. Epub 2020 Feb 19. PMID: 32201861

Bao X, Wu J, Xie Y, Kim S, Michelhaugh S, Jiang J, Mittal S, Sanai N, Li J. Protein Expression and Functional Relevance of Efflux and Uptake Drug Transporters at the Blood-Brain Barrier of Human Brain and Glioblastoma. Clin Pharmacol Ther. 2020 May;107(5):1116-1127. doi: 10.1002/cpt.1710. Epub 2019 Dec 10. PMID: 31664714

Karki K, Li X, Jin UH, Mohankumar K, Zarei M, Michelhaugh SK, Mittal S, Tjalkens R, Safe S. Nuclear receptor 4A2 (NR4A2) is a druggable target for glioblastomas. J Neurooncol. 2020 Jan;146(1):25-39. doi: 10.1007/s11060-019-03349-y. Epub 2019 Nov 21. PMID: 31754919

Gajan A, Martin CE, Kim S, Joshi M, Michelhaugh SK, Sloma I, Mittal S, Firestine S, Shekhar MPV. Alternative Splicing of RAD6B and Not RAD6A is Selectively Increased in Melanoma: Identification and Functional Characterization. Cells. 2019 Nov 1;8(11):1375. doi: 10.3390/cells8111375. PMID: 31683936

Jin UH, Karki K, Cheng Y, Michelhaugh SK, Mittal S, Safe S. The aryl hydrocarbon receptor is a tumor suppressor-like gene in glioblastoma. J Biol Chem. 2019 Jul 19;294(29):11342-11353. doi: 10.1074/jbc.RA119.008882. Epub 2019 Jun 6. PMID: 31171720

John F, Bosnyák E, Robinette NL, Amit-Yousif AJ, Barger GR, Shah KD, Michelhaugh SK, Klinger NV, Mittal S, Juhász C. Multimodal imaging-defined subregions in newly diagnosed glioblastoma: impact on overall survival. Neuro Oncol. 2019 Feb 14;21(2):264-273. doi: 10.1093/neuonc/noy169. PMID: 30346623