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Amy Shore, Ph.D.

Research Scientist
  • Weston Lab

Amy Shore earned her doctorate in Developmental Biology, and she focused her doctoral and postdoctoral research on understanding signaling pathways that regulate mammary gland development, and how disruption of these pathways can result in mammary tumorigenesis. In the Weston Lab, her research focus is on identifying how epilepsy-causing gene variants alter molecular pathways and synaptic function in the developing brain to disrupt neuronal networks and cause seizures.

  • Baylor College of Medicine, Ph.D., Developmental Biology
  • University of Virginia, B.A., Biological Sciences

McCabe MP, Shore AN, Frankel WN, Weston MC. Altered fast synaptic transmission in a mouse model of DNM1-associated developmental epileptic encephalopathy. eNeuro. 2021 Mar 10;8(2):ENEURO.0269-20.2020.

Shore AN, Colombo S, Tobin WF, Petri S, Cullen ER, Dominguez S, Bostick CD, Beaumont MA, Williams D, Khodagholy D, Yang M, Lutz CM, Peng Y, Gelinas JN, Goldstein DB, Boland MJ, Frankel WN, Weston MC. Reduced GABAergic neuron excitability, altered synaptic connectivity, and seizures in a KCNT1 gain-of-function mouse model of childhood epilepsy. Cell Rep. 2020 Oct 27;33(4):108303.

McCabe MP, Cullen ER, Barrows CM, Shore AN, Tooke KI, Laprade KA, Stafford JM, Weston MC. Genetic inactivation of mTORC1 or mTORC2 in neurons reveals distinct functions in glutamatergic synaptic transmission. Elife. 2020 Mar 3;9. pii: e51440.

Sah M, Shore AN, Petri S, Kanber A, Yang M, Weston MC, Frankel WN. Altered excitatory transmission onto hippocampal interneurons in the IQSEC2 mouse model of X-linked neurodevelopmental disease. Neurobiol Dis. 2020 Apr;137:104758.

Shore AN, Chang CH, Kwon OJ, Weston MC, Zhang M, Xin L, Rosen JM. PTEN is required to maintain luminal epithelial homeostasis and integrity in the adult mammary gland. Dev Biol. 2016 Jan 1;409(1):202-17.

Roarty K, Shore AN, Creighton CJ, Rosen JM. Ror2 regulates branching, differentiation, and actin-cytoskeletal dynamics within the mammary epithelium. J Cell Biol. 2015 Feb 2;208(3):351-66.

Shore AN, Rosen JM. Regulation of mammary epithelial homeostasis by lncRNAs. Int J Biochem Cell Biol. 2014 Sep;54:318-30. 

Villegas E, Kabotyanski EB, Shore AN, Creighton CJ, Westbrook TF, Rosen JM. Plk2 regulates mitotic spindle orientation and mammary gland development. Development. 2014 Apr;141(7):1562-71.

Zhang L, Zhang B, Han SJ, Shore AN, Rosen JM, DeMayo FJ, Xin L. Targeting CreERT2 expression to keratin 8-expressing murine simple epithelia using bacterial artificial chromosome transgenesis. Transgenic Res. 2012 Oct;21(5):1117-23.

Shore AN, Kabotyanski E, Roarty K, Smith MA, Zhang Y, Creighton CJ, Dinger ME, Rosen JM.  Pregnancy-induced noncoding RNA (PINC) associates with polycomb repressive complex-2 and regulates mammary epithelial differentiation. PLOS Genet. 2012;8(7):e1002840.

Shore AN, Herschkowitz JI, Rosen JM. Long noncoding RNAs involved in mammary gland development and tumorigenesis: There’s a long way to go. J Mammary Gland Biol Neoplasia. 2012 March; 17(1):43-58.

Acharya KK, Govind CK, Shore AN, Stoler MH, Reddi PP. cis-requirement for the maintenance of round spermatid-specific transcription. Dev Biol. 2006 Jul 15;295(2):781-90.

Ginger MR, Shore AN, Contreras A, Rijnkels M, Miller J, Gonzalez-Rimbau MF, Rosen JM. A noncoding RNA is a potential marker of cell fate during mammary gland development. Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5781-6.

Reddi PP, Shore AN, Shapiro JA, Anderson A, Stoler MH, Acharya KK. Spermatid-specific promoter of the SP-10 gene functions as an insulator in somatic cells. Dev Biol. 2003 Oct 1;262(1):173-82.

Wright PW, Bolling LC, Calvert ME, Sarmento OF, Berkeley EV, Shea MC, Hao Z, Jayes FC, Bush LA, Shetty J, Shore AN, Reddi PP, Tung KS, Samy E, Allietta MM, Sherman NE, Herr JC, Coonrod SA. ePAD, an oocyte and early embryo-abundant peptidylarginine deiminase-like protein that localizes to egg cytoplasmic sheets. Dev Biol. 2003 Apr 1;256(1):73-88.

Reddi PP, Shore AN, Acharya KK, Herr JC. Transcriptional regulation of spermiogenesis: insights from the study of the gene encoding the acrosomal protein SP-10. J Reprod Immunol. 2002 Jan;53(1-2):25-36.

Hao Z, Stoler MH, Sen B, Shore A, Westbrook A, Flickinger CJ, Herr JC, Coonrod SA. TACC3 expression and localization in the murine egg and ovary. Mol Reprod Dev. 2002 Nov;63(3):291-9.

Bush LA, Herr JC, Wolkowicz M, Sherman NE, Shore A, Flickinger CJ. A novel asparaginase-like protein is a sperm autoantigen in rats. Mol Reprod Dev. 2002 Jun;62(2):233-47.

     

  

THE WESTON LAB