Yu Lab
THE YU LAB
Children's National Research & Innovation Campus
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Home ItemJia-Ray Yu, Ph.D. , home
Assistant Professor
Led by principal investigator Jia-Ray Yu, Ph.D., the Yu Laboratory studies the regulations of gene expression at the chromatin level. As chromatin is a highly compartmentalized structure, the temporo-spatial regulations of the chromatin-associated factors are crucial for their collective functions in shaping the epigenome. These natural principles are, however, often dysregulated in human diseases such as congenital developmental syndromes and a variety types of cancer.
The lab probes these questions by integrating comprehensive research tools in chromatin biochemistry, reconstituted systems, deep-sequencing, molecular and cell biology, and cancer biology. The current focuses in lab include the following directions: 1) functional regulation of chromatin modifying enzymes by novel protein-RNA and protein-protein interactions; 2) how disruption of balancing between heterochromatin and euchromatin contributes to early oncogenesis in pediatric brain cancers; and 3) non-histone targets of histone-modifying enzymes.
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Bio ItemChen-I Hsu , bio
Graduate Student, Biomedical and Veterinary Sciences, Virginia-Maryland College of Veterinary Medicine
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Bio ItemHung-Ju Ko , bio
Research Associate
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Bio ItemYen-Her Lai , bio
Research Associate
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Article Item‘We have a very rich resource here’ , article Date: Jun 20, 2023
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