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Dr. Finkielstein's Publications

For a more complete list of publications, visit the following publication sites: PubMed or Google Scholar.

Aiello I., Mul Fedele M.L., Román F., Marpegan L., Caldart C., Chiesa J.J., Golombek D.A., Finkielstein, C.V. and Paladino N. (2020) Circadian disruption promotes tumor immune microenvironment remodeling favoring tumor cell proliferation. Co-corresponding authors.  Science Advances 6(42): eaaz4530.

Song W., Gottschalk C.J., Tang T.X., Biscardi A., Ellena J.F., Finkielstein, C.V., Capelluto D.G.S (2020) Structural, in silico, and functional analysis of Disabled-2-derived peptide for recognition of sulfatides. Scientific Reports 10:13520.

Zou X., Kim D., Gotoh T., Liu J.J., Kim J., Finkielstein, C.V. (2020) A systems biology approach identifies hidden regulatory connections between the circadian and cell-cycle checkpoints. Frontiers of Physiology, Systems Biology Issue, 11:327.

Tang T.X., Finkielstein, C.V., Capelluto D.G.S. (2020) The C-terminal acidic motif of Phafin2 inhibits PH domain binding to phosphatidylinositol 3-phosphate. Biochimica et Biophysica Acta (BBA) 1862(6):183230.

JingJing Liu, Xianlin Zou, Tetsuya Gotoh, Anne M. Brown, Liang Jiang, Esther L. Wisdom, Jae Kyoung Kim and Carla V. Finkielstein. (2018). Distinct control of PERIOD2 degradation and circadian rhythms by the oncoprotein and ubiquitin ligase MDM2. Science Signaling 11(556).

Gotoh T., Zou X., Finkielstein C.V. (2018) Circadian-tumor suppressor crosstalk: Emerging opportunities in cancer chronotherapy. PostDoc Journal 6(3):20-22 PDF

Foster J., Radzinski S., Zou X., Finkielstein C.V., Matson J. (2017) H2S-releasing polymer micelles for studying selective cell toxicity. Molec. Pharm. 14(4):1300-1306. PDF

Zhao X., Xiong W., Xiao S., Tang T-X., Ellena J., Armstrong G., Finkielstein C.V., Capelluto D.G.S. (2017) Membrane targeting of TIRAP is negatively regulated by phosphorylation in its phosphoinositide-binding motif. Scientific Reports 7:43043 PDF

Tang T-X., Xiong W., Finkielstein C.V., and Capelluto D.G.S. (2017) Identification of ligand-binding modulators using the protein-lipid overlay assay, Proteomics for Drug Discovery. Meth. Mol. Biol. 1647:197-206 PDF

Tetsuya Gotoh, Jae Kyoung Kim, Jingjing Liu, Marian Vila-Caballer, Philip E. Stauffer, John J. Tyson, and Carla V. Finkielstein. (2016). Model-driven experimental approach reveals the complex regulatory distribution of p53 by the circadian factor Period 2. Proceedings of the National Academy of Sciences 113(47).

Mercau M.E., Repetto E.M., Perez M.N., Calejman C.M., Finkielstein C.V., Cymeryng C.B. (2016) Role of CREB on heme oxygenase-1 induction in adrenal cells. Involvement of the PI3K pathway. J. Mol. Endoc. 57(2):113-124.

Mercau M.E., Repetto E.M., Perez M.N., Calejman C.M., Finkielstein C.V., Cymeryng C.B. (2016) Moderate exercise prevents functional remodeling of the anterior pituitary ?gland in diet-induced insulin resistance in rats: role of oxidative stress and autophagy. Endocrinology 157(3):1135-1145. PDF

Julia M. Selfridge, Tetsuya Gotoh, Samuel Schiffhauer, JingJing Liu, Philip E. Stauffer, Andrew Li, Daniel G. S. Capelluto, and Carla V. Finkielstein. (2016). Chronotherapy: Intuitive, Sound, Founded…But Not Broadly Applied. Drugs 76: 1507–1521.

Finkielstein C.V. and Capelluto D.G.S. (2016) Disabled-2: a modular scaffold protein with multifaceted functions in signaling. Bioessays 38(1):S45-55.

Selfridge J.M., Moyer K., Capelluto D.G.S., Finkielstein C.V. (2015) Opening the debate: How to fulfill the need for physicians' training in circadian-related topics in a full medical school curriculum. J. Circ. Rhythms 13(7):1-10. PDF

Adams P., Finkielstein C.V., Glass M., Karlsson C., Turner C. (2015) Susan G. Komen Community Profile Report. Virginia Blue Ridge Affiliate. p.1-99

Xiao S., Brannon M.K., Zhao X., Fread K., Ellena J.F., Bushweller J.H., Finkielstein C.V., Armstrong G., Capelluto D.G.S. (2015) Tom1 negatively modulates binding of Tollip to phosphatidylinositol 3-phosphate via a coupled folding and binding mechanism. Structure, 23(10):1910-1920. Commentary in Structure 23(10):1781-1782; "Time to fold: Tom1 uses new tricks to regulate lipid binding of Tollip."

Gotoh T., Vila-Caballer M., Liu J.J., Schiffhauer S., Finkielstein C.V. (2015) Association of the circadian factor Period 2 to p53 influences p53's function in DNA-damage signaling. Mol. Biol. Cell 26(2):359-372. PDF

Selfridge J.M., Moyer K., Capelluto D.G.S., Finkielstein C.V. (2015) Opening the debate: How to fulfill the need for physicians' training in circadian-related topics in a full medical school curriculum. J. Circ. Rhythms 13(7):1-10.

Finkielstein C.V. (2015) Cancer protection: Follow the biological clock. In, Series: Countering Cancer, 100 Reports from the Frontline, Eds. Pfizer in cooperation with Handelsblatt Global Ed. Chapter 52, In press.

Finkielstein C.V. and Capelluto D.G.S. (2015) Disabled-2: a modular scaffold protein with multifaceted functions in signaling. Wiley Ed. iCell vol. 1:1-11.<br>

Lucas, A.T., Fu, X., Liu J.J., Brannon M.K., Yang, J., Capelluto D.G.S., Finkielstein C.V. (2014) Ligand binding reveals a role for heme in transitionally-controlled tumor protein dimerization. PLoS ONE 9(11):e11823 PDF

Gotoh T., Vila-Caballer M., Santos C.S., Liu J.J., Yang J., Finkielstein C.V. (2014) The circadian factor Period 2 modulates p53 stability and transcriptional activity in unstressed cells. Mol. Biol. Cell 25(19):3081-3093. PDF

Capelluto D.G.S., Zhao X., Lucas A., Lemkul J., Xiao S., Fu X., Sun F., Bevan D., and Finkielstein C.V. (2014) Biophysical and molecular simulations studies of phosphatidic acid binding by the Dishevelled-2 DEP domain. Biophys. J. 106(5):1101-1111. Third Place Winner (ENC 2014, Boston, MA, March 24th-26th) "NMR is GOOD" Contest, Cambridge Isotope Laboratories, Inc. PDF

Xiao S., Zhao X., Finkielstein C.V., and Capelluto D.G.S. (2014) A rapid procedure to isolate isotopically-labeled peptides for NMR studies: Application to the Disabled-2 sulfatide-binding motif. J. Pept. Sci. 20(3):216-222. PDF

Larion S., Caballes F.R., Hwang, S-I, Lee J-G, Ellefson-Rossman W., Parsons J., Steuerwald N., Li T., Maddukuri V., Groseclose G., Finkielstein C.V., Bonkovsky H. (2013) Circadian rhythms in acute intermittent porphyria – a pilot study. Eur. J. of Clin. Investigation 43(7):727-739. Special mention for its novelty and importance at the Annual Assembly of the Swiss Society of Clinical Chemistry & International Congress of Porphyrins and Porphyrias 2013, Lucerne, Switzerland. PDF

Xiao S., Charonko J.J., Salmanzadeh A., Davalos R.V., Vlachos P.P., Finkielstein C.V, Capelluto D.G. (2012) Structure, sulfatide-binding properties, and inhibition of platelet aggregation by a Disabled-2-derived peptide. J. Biol. Chem. 287(45):37691-37702. PDF

Alajlouni R., Drahos, K.E., Finkielstein C.V., Capelluto D.G.S. (2011) Lipid-mediated membrane binding properties of Disabled-2. BBA Biomembranes 1808(11):2734-2744. PDF

Welsh J.D., Charonko J.J., Salmanzadeh-Dozdabi A., Drahos K.E., Shafiee H., Stremler M.A., Davalos R.V., Vlachos P.P., Capelluto D.G.S., Finkielstein C.V. (2011) Disabled-2 modulates homotypic and heterotypic platelet aggregation by binding to sulfatides. Br. J. of Haematol. 154(1):122-133. PDF

Cordoba L., Huang Y-W, Opriessnig T., Harral K.K., Beach N.M., Finkielstein C.V., Emerson S.U., Meng X.J. (2011) Three amino acid mutations (F51L, T59A and S390L) on the capsid protein of the hepatitis E virus collectively contribute to virus attenuation. J. of Virol. 85(11): 5338-5349. PDF

Howells, C.C., Baumann, W.T., Samuels, D.C., Finkielstein C.V. (2011). The Bcl-2-Associated Death Promoter (BAD) Lowers the Threshold at which the Bcl-2-Interacting Domain Death Agonist (BID) Triggers Mitochondria Disintegration. In press J. Theor. Biol. 271(1):114-123 PDF

Gotoh T., Villa L.M., Capelluto D.G.S., Finkielstein C.V. (2011) Regulatory Pathways Coordinating Cell Cycle Progression in Early Xenopus Development. In, Cell Cycle in Development. Series: Results and Problems in Cell Differentiation. Ed. J. Kubiak, In press, Springer US Ed.

Allen, W.J., Capelluto D.G.S., Finkielstein C.V., Bevan D.R. (2010). Modeling the relationship between the p53 C-terminal domain and its binding partners using molecular dynamics. J. Phys. Chem. B 114(41):13201-13213. PDF

Arzumendi H., Mitra S., Ayala I., Li L., Finkielstein C.V., Capelluto D.G.S. (2010). Backbone 1H, 15N, and 13C resonance assignments and secondary structure of the Tollip CUE domain. Mol. Cells 30(6):581-585. PDF

Armenta J.M., Perez M., Yang X., Shapiro D., Reed D., Tuli L., Finkielstein C.V. and Lazar I.M. (2010) Fast Proteomic Protocol for Biomarker Fingerprinting in Cancerous Cells. J. Chromatogr. A. 1217(17):2862-2870.

Dong J, Mury SP, Drahos KE, Moscovitch M, Zia RK, Finkielstein CV (2010) Shorter Exposures to Harder X-Rays Trigger Early Apoptotic Events in Xenopus laevis Embryos. PLoS ONE 5(1):e8970. PDF

Drahos, K.E., Welsh J.D., Finkielstein C.V.*, Capelluto D.G.S.* (2009) Sulfatides Partition Disabled-2 in Response to Platelet Activation. PLoS ONE 4(11):e8007. * equal contribution, corresponding authors. PDF

Sweede, M, Shbeir S., Watkins, J, Howard K., Finkielstein C.V. and Capelluto D.G.S. (2008) Structural analysis of the PET domain: role in Prickle dimerization. Biochemistry 47(51):13524-13536.

Yang J., Kim K.D., Lucas A., Drahos K.E., Santos C.S., Mury S.P., Capelluto D.G.S., Finkielstein C.V. (2008). A Novel Heme Regulatory Motif Mediates Heme-Dependent Degradation of the Circadian Factor Period 2. Mol. Cell Biol. 28(15):4697-4711. PDF

Wroble B.N., Finkielstein C.V., Sible J.C. (2007). Wee1 kinase alters Cyclin E/Cdk2 and promotes apoptosis during the early embryonic development of Xenopus laevis. Dev. Biol. 7(1):119-124.

Finkielstein C. V., Overduin M., Capelluto D.G.S. (2006). Cell Migration and signaling specificity is determined by Rac1's phosphatidylserine recognition motif. J. Biol. Chem. 281(37):27317-26. PDF

Gai D., Zhao R., Finkielstein C. V., Chen X.S. (2004). Mechanisms of conformational change for a replicative hexameric helicase of SV40 large T antigen. Cell 119(1):47-60. PDF

Gai D., Li D., Finkielstein C. V., Ott R.D., Taneja P., Fanning E., Chen X. (2004). Insights into the Oligomeric States, Conformational Changes and Helicase Activities of SV40 Large Tumor Antigen. J. Biol. Chem. 279(37):38952-38959. PDF

Bemis L., Chan D.A., Finkielstein C. V., Qi L., Stutphin P.D., Chen X., Stenmark K., Giaccia A.J., Zundel W. (2004). Distinct aerobic and hypoxic mechanisms of HIF-alpha regulation by CSN5. Genes Dev. 18(7):739-744. PDF

Capelluto D.G.S., Kutateladze T.G.*, Habas R. *, Finkielstein C. V. *, Xi H., Overduin M. (2002). DIX domain targets dishevelled to actin stress fibers and vesicular membranes. * Equal contribution. Nature 419(6908):726-729.

Cymeryng C.B., Lotito S.P., Colonna C., Finkielstein C. , Pomeraniec Y., Grion N., Gadda L., Maloberti P., Podesta E.J. (2002). Expression of nitric oxide synthases in rat adrenal zona fasciculata cells. Endocrinology 143(4):1235-1242. PDF

Finkielstein C. V., Lin G., Maller J.L. (2002). A role for G1/S cyclin-dependent protein kinases in the apoptotic response to ionizing radiation. J. Biol. Chem. 277(41):38476-38485. PDF

Finkielstein C. V., Lewellyn A., Maller J.L. (2001). The midblastula transition in Xenopus embryos activates multiple mechanisms to prevent apoptosis in response to DNA damage. Proc. Natl. Acad. Sci. 98(3):1006-1011. PDF

Maller J.L., Gross S.D., Schwab M.S., Finkielstein C. V., Taieb F.E., Qian Y.W. (2001). Cell Cycle Transitions in early Xenopus development. In: The Cell Cycle and Development, eds. J. Wiley & Sons, Novartis Found. Symp. 237:58-78.

Neuman I., Lisdero C., Finkielstein C., Maloberti P., Mendez C.F., Poderoso J.J., Podesta E.J. (1999). Activation of a thioesterase specific for very-long-chain fatty acids by adrenergic agonists in perfused hearts. Biochimica et Biophysica Acta 1451(1):101-108. PDF

Finkielstein C. V., Maloberti P., Mendez C.F., Paz C., Cornejo Maciel F., Cymeryng C., Neuman I., Dada L., Mele P.G., Solano A., Podesta E.J. (1998). An adrenocorticotropin-regulated phosphoprotein intermediary in steroid synthesis is similar to an acyl-CoA thioesterase enzyme. Eur. J. Biochem. 256(1):60-66. PDF

Finkielstein C. V., Maloberti P., Mendez C.F., Podesta E.J. (1998). A novel arachidonic acid-related thioesterase involved in acute steroidogenesis. Endocrine Research 24(3-4):363-371.

Mele P., Dada L., Paz C., Cymeryng C., Cornejo Maciel M., Neuman M., Finkielstein C., Mendez C.F., Podesta E.J. (1997). Involvement of arachidonic acid and the lypoxigenase pathway in mediating luteinizing hormone-induced testosterone synthesis in rat Leydig cells. Endocrine Research 23(1-2):15-26.

Mele P., Dada L., Paz C., Cymeryng C., Cornejo Maciel M., Neuman M., Finkielstein C., Mendez C., Podesta E.J. (1996). Site of action of proteinases in the activation of steroidogenesis in rat adrenal gland. Biochimica et Biophysica Acta 1310(3):260-268.

Finkielstein C., Cymeryng C., Paz C., Neuman M., Dada L., Cornejo Maciel M., Mele P., Mendez C.F., Solano A., Schimmer B.P., Podesta E.J. (1996). Characterization of the cDNA corresponding to a phosphoprotein (p43) intermediary in the action of ACTH. Endocrine Research 22(4):521-532.

Dada L., Cornejo Maciel M., Neuman M., Mele P., Paz C., Cymeryng C., Finkielstein C., Mendez C.F., Podesta E.J. (1996). Cytosolic and mitochondrial proteins as possible targets of cycloheximide effect on steroidogenesis. Endocrine Research 22(4):533-539.

Cymeryng C., Paz C., Dada L., Cornejo Maciel M., Mele P., Neuman M, Mendez C.F., Finkielstein C., Solano A., Park M., Fisher W., Towbin H., Scartazzini R., Podesta E.J. (1995). ACTH-dependent proteolytic activity of phosphoprotein (p43) intermediary in the activation of arachidonic acid release and steroidogenesis. Endocrine Research 21(1-2):281-288.

Paz C., Dada L., Cornejo Maciel M., Mele P., Cymeryng C., Neuman M., Mendez C.F., Finkielstein C., Park M., Towbin H., Scartazzini R., Solano A., Podesta E.J. (1994). Purification of a novel protein (p43) as intermediary in the activation of steroidogenesis from rat adrenal gland. Eur. J. of Biochem. 224(2):709-716.

Levin M., Levitus G., Kerner N., Mesri E., Schijman A., Levy-Yeyati P., Finkielstein C., Chiale P., Schejtman D., Hontebeyrie-Joskowicz M. (1990). Autoantibodies in Chagas' Heart Disease: Possible Markers of Severe Chagas' Heart Complaint. Memorias Do Instituto Oswaldo Cruz. An International Journal of Biological and Biomedical Research. 85(2)110-115.