Qi Ye, Ph.D.
"Astrocytes and other glial cells use conserved programs for brain development and repair-programs that glioma tumors can hijack to drive malignant growth. By integrating fundamental neuroscience and cancer biology, my lab investigates how astrocytes interact with the tumor microenvironment to regulate glioma progression."
Understanding brain cancer through a neuroscience lens
How do astrocytes shape the tumor microenvironment and influence glioma progression?
Astrocytes, some of the most abundant cells in the brain, play essential roles in development, repair, and disease. Qi Ye studies how astrocytes interact with the tumor and the tumor microenvironment to promote glioma growth and progression.
By integrating neuroscience with cancer biology, Ye's lab seeks to understand how normal brain repair programs become co-opted during malignancy. Using advanced mouse glioma models, multi-omics technologies, cross-species data analysis, and high-resolution imaging, the lab focuses on how tumor-associated astrocytes regulate blood vessel function and lipid metabolism within the tumor environment.
Ye's goal is to uncover new, cell-specific therapeutic strategies to improve survival for patients with glioma while training the next generation of scientists in a rigorous, inclusive research environment.
qiye@vt.edu
202-960-1858
Room 6224, Children's National Research and Innovation Campus
- Assistant Professor, Fralin Biomedical Research Institute at VTC
- Assistant Professor, Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine
Ye Q, Madamba C, Woo J, Choy TJ, Cristobal CD, Spjut C, Wheeler K, Smith J, Shin D, Latha K, Harmanci A, Yalamanchili HK, Gallo M, Kim Y, Rao G, Deneen B, Lee HK. Ischemic stroke drives glioma progression by remodeling tumor-associated astrocytes (Under revision).
Ye Q, Jo J, Wang C, Oh H, Choy TJ, Kim K, Alessandro DA, Reshetnyak YK, Jung SY, Chen Z, Marrelli SP, Lee HK (2024). Astrocytic Slc4a4 regulates blood-brain barrier integrity in healthy and stroke brains via a CCL2-CCR2 pathway and NO dysregulation. Cell Reports, 28;43(5):114193 (PMID: 38709635)
Chung H*, Ye Q*, Park Y, Lanza I, Oglesbee D, Kanca O, Tattikota S, Zuo Z, Perrimon N, Lee HK, Hugo J. Bellen (2023). Very-long-chain fatty acids induce glial-derived sphingosine-1-phosphate synthesis, secretion, and neuroinflammation. Cell Metabolism. 35(5):855-874.e5 (PMID: 37084732)
Ye Q, Trivedi M, Zhang Y, MarK B, Alsulimani H, Chang J, Maher T, Deth R, Kim J (2019). Brain iron loading impairs DNA methylation and alters GABAergic function in mice. FASEB. 33(2):2460-2471 (PMID: 30277817)
Postdoctoral Fellow in Glial Biology, Baylor College of Medicine
- M.S. and Ph.D, Pharmacology and Toxicology, Northeastern University
- B.S, Pharmacy, Central South University College of Pharmacy
- Dean's Award of Excellence, the Graduate School of Biomedical Sciences, Baylor College of Medicine
- K99 Pathway to Independence Awards, Natinal Cancer Institute, National Institutes of Health
- The Zoghbi Scholar Award, Neurological Research Institute, Texas Children's Hospital Marvin and Gloria Fishman Trainee Endowed Fund Travel Scholarship, Texas Children's Hospital The Young Investigator's Educational Enhancement (YIEE), American Society of Neurochemistry, Virtual meeting
- Best Oral Presentation (5 out of 140), Pediatric Research Symposium, Texas Children's Hospital, Houston, TX
- The John L. Neumeyer Research Achievement Award (1 graduate student per year), Northeastern University, Boston, MA
- Poster of Distinction by the Programming Committee of the Gastrointestinal & Liver Section of the American Physiology Society, San Diego, CA
- Health Science Poster Award Winner (co-author), Research, Innovation, and Scholarship Expo (RISE), Boston, MA
- Xiangya Medical School outstanding undergraduate thesis (8 in 70), Central South University, China
- Outstanding graduates (3 in 70), Central South University, China
- Scholarship for top undergraduate students in the pharmaceutical science department (3 in 70), Central South University, China
- National Merit Scholarship (0.2% nationwide), Central South University, China