Hemangi Bhonsle, Ph.D.
- Yan Lab
Hemangi earned her Ph.D. in Biotechnology from CSIR-National Chemical Laboratory in India under the guidance of Dr. Mahesh Kulkarni. During her doctoral studies, she comprehensively studied the relationship between albumin levels and plasma protein glycation in diabetes both in vitro and in vivo. Hemangi was awarded with Lady Tata Memorial Trust fellowship throughout her Ph.D. training. She completed a postdoctoral fellowship at Tata Memorial Center in India, where she identified galectin-3-binding membrane glycoproteins in lung melanoma and established their role in metastasis-associated process. Hemangi completed another three-year postdoctoral tenure at Tata Institute of Fundamental Research (TIFR) with Prof. Roop Mallik, where she was involved in understanding how triglyceride is secreted from mouse liver during the feeding-fasting cycles by using biochemical assays and mass spectrometry-based proteomics. During her tenure at TIFR, Hemangi was awarded with a highly prestigious India Alliance DBT Wellcome Trust Early Career Fellowship in 2019-2020. Further continuing her research in disease biology, she joined Dr. Sarika Srivastva lab at the Fralin Biomedical Research Institute at VTC to work on the role of neuronal calcium/calmodulin dependent serine kinase (CASK) in postnatal brain development in mice. In particular, this work explored the role of mitochondria in pathophysiology of neurological diseases. To further explore the role of mitochondria in health and disease, Hemangi joined Yan lab at the Center for Exercise Medicine Research at the Fralin Biomedical Research Institute, where she is now working on identifying and elucidating the functional roles of exercise-mediated humoral factors. She will be using the state-of-the-art mouse molecular genetics, cell biology and imaging approaches in her studies.
- University of Pune, India, Ph.D., Biotechnology
- Pravara Rural University, India, MSc., Medical Biotechnology
Research Associate, Dr. Zhen Yan Lab, Center for Exercise Medicine Research, Fralin Biomedical Research Institute at VTC, Roanoke, VA, USA, Dec 2023- present
Research Associate, Dr. Sarika Srivastava Lab, Fralin Biomedical Research Institute at VTC, Roanoke, VA, USA, 2022-2023
Postdoctoral Fellow, Dr. Roop Mallik Lab, Tata Institute of Fundamental Research, Mumbai, India, 2017-2020
Postdoctoral Research Associate, Dr. Rajiv Kalaraiya Lab, Advanced Centre for Treatment, Research and Education in Cancer, Navi Mumbai, India, 2013
Research Project Assistant-II, Dr. Mahesh J. Kulkarni Lab, CSIR-National Chemical Laboratory, Pune, India, 2007- 2008
Kamerkar S, Singh J, Tripathy S, Bhonsle HS, Kumar M, Mallik R. Metabolic and immune-sensitive contacts between lipid droplets and endoplasmic reticulum reconstituted in vitro. Proc Natl Acad Sci U S A. 2022 Jun 14;119(24): e2200513119. doi: 10.1073/pnas.2200513119.
Dange MC, Bhonsle HS, Godbole RK, More SK, Bane SM, Kulkarni MJ, Kalraiya RD. Mass spectrometry-based identification of galectin-3 interacting proteins potentially involved in lung melanoma metastasis. Mol Biosyst. 2017; 13, 2303-2309.
Sacheti P, Patil R, Dube A, Bhonsle HS, Thombre D, Marathe S, Vidhate R, Wagh P, Kulkarni M, Rapole S, Gade W. Proteomics of arsenic stress in the gram-positive organism Exiguobacterium sp. PS NCIM. Appl Microbiol Biotechnol. 2014; 98, 6761-6773.
Sacheti P, Bhonsle HS, Patil R, Kulkarni MJ, Srikanth R, Gade WN. Arsenomics of Exiguobacterium sp. PS (NCIM 5463). 2013 RSC Adv. 3, 9705-9713.
Korwar AM, Bhonsle HS, Ghole VS, Gawai KR, Koppikar CB, Kulkarni MJ. Proteomic profiling and interactome analysis of ER-positive/HER2/neu negative invasive ductal carcinoma of the breast: towards proteomics biomarkers. OMICS, 2013; 17, 27-40
Bhonsle HS, Korwar AM, Chougale AD, Kote SS, Dhande NL, Shelgikar KM, Kulkarni MJ. Proteomic study reveals downregulation of apolipoprotein A1 in plasma of poorly controlled diabetes: a pilot study. Mol Med Rep. 2013; 7, 495-498.
Kulkarni MJ, Korwar AM, Mary S, Bhonsle HS, Giri AP. Glycated proteome: from reaction to intervention. Proteomics Clin Appl. 2012; 7, 155-170.
Korwar AM, Bhonsle HS, Chougale AD, Kote SS, Gawai KR, Ghole VS, Koppikar CB, Kulkarni MJ. Analysis of AGE modified proteins and RAGE expression in HER2/neu negative invasive ductal carcinoma. Biochem Biophys Res Commun. 2012; 419, 490-494.
Bhonsle HS, Korwar AM, Kote SS, Golegaonkar SB, Chougale AD, Shaik ML, Dhande NL, Giri AP Shelgikar KM, Boppana R, Kulkarni MJ. Low plasma albumin levels are associated with increased plasma protein glycation and HbA1c in diabetes. J Proteome Res. 2012; 11, 1391-1396
Bhonsle HS, Korwar AM, Kesavan SK, Bhosale SD, Bansode SB, Kulkarni MJ. ‘Zoom-ln’- A targeted database search for identification of glycation modifications analyzed by untargeted tandem mass spectrometry. Eur J Mass Spectrom (Chichester, Eng). 2012; 18, 475-481
Golegaonkar SB, Bhonsle HS, Boppana R, Kulkarni MJ. Discovery of rifampicin as a new anti-glycating compound by matrix-assisted laser desorption/ionization mass spectrometry-based insulin glycation assay. Eur J Mass Spectrom (Chichester, Eng). 2010; 16, 221-226.
Bhonsle HS, Singh SK, Srivastava G, Boppana R, Kulkarni MJ. Albumin competitively inhibits glycation of less abundant proteins. Protein Pept Lett., 2008; 15, 663-667.
India Alliance Wellcome DBT Early Career Fellowship, 2019 (declined). Equivalent to NIH- K01 award. Total funds - $200K over the period of 5 years, 2019-2020.
TIFR-Post-doctoral fellowship. Tata Institute of Fundamental Research, India, 2017-2020.
Lady Tata Memorial Trust Pre-Doctoral Research Scholarship, India, 2008-2012.