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Non-communicable diseases, such as cardiovascular, metabolic and neurodegenerative diseases and cancer, cause more than 60% of the death in the USA and account for more than 75% of health care costs. Regular exercise has profound health benefits and is the most powerful intervention in disease prevention and treatment. The Yan Lab, led by Zhen Yan, Ph.D., director of the Fralin Biomedical Research Institute at VTC Center for Exercise Medicine Research, employs the state-of-the-art molecular genetics and imaging technologies in a variety of animal models to elucidate the underlying molecular and signaling mechanisms of exercise training-induced adaptations and the impacts on health and disease.

Yan Lab News

  • June 13, 2024: Mr. Silver presented his findings of exercise impact on the immune system at FBRI retreat at Homestead, Hotspring, Virginia.
  • June 11, 2024: Dr. Yan's contribution to MoTrPAC was featured in Virginia Tech News
  • May 28, 2024: Dr. Mao presented at FRBI RIP seminar. 
  • May 9-10: Drs.  Bhonsle and Yan attended MoTrPAC Steering Committee Meeting at NIH. 
  • May 1, 2024: MoTrPAC published three highly impatful papers in Nature series with Dr. Yan as a co-author of the consortium. 
  • January 25, 2024: Congratualtions to Yuntian Guan for successful Ph.D. dissertation defense at historical dome room of Rotunda at Univeristy of Virginia. Good luck, Dr. Guan, for your post-doctoral research at Harvard!
  • January 9, 2024: Dr. Yan presented at Virginia Tech Center for Drug Discovery entitled: "Target activation of mitoAMPK for NCD". 
  • December 31, 2023: Ph.D. Student Yuntian Guan's paper entitled: "Endurance Exercise Training Mitigates Diastolic Dysfunction in Diabetic Mice Independent of Phosphorylation of Ulk1 at S555" was accepted by Int J Mol Sci
  • December 22, 2023: Center for Exercise Medicine Research (CEMR) 2023 Christmas Party was held at Yan Residence in Roanoke
  • November 14, 2023: Dr. Ryan Montalvo presented at Fralin Biomedical Research Institute Research in Progress seminar entitled: "The Role of AMPK in Cardiac and Skeletal Muscle Function, Bioenergetics, and Mitochondrial Quality Control"
  • October 24, 2023: Dr. Yan presented: "Otud1 in skeletal msucle contractile and metabolic health" at Novo Nordisk Greenhouse Idea Pitching Session
  • October 13, 2023: Dr. Yan talked to first-medical students at Research Domain: Research Alive at VTC Medical School, Roanoke
  • October 9, 2023: Dr. Yan presented "AMPK in metabolic regulation and adaptation in response to exercise" at Center for Vascular and Heart Research Symposium at the Fralin Biomedical Research Institute at VTC, Roanoke


Celebration of Yuntian's successful defense for his Ph.D. research on January 25, 2024