Research Projects

Our lab focuses on understanding cancer dependencies--why cancers rely on certain genes and proteins to survive, and how we can drug them to make new therapies for cancer patients. Several projects in the lab focus on understanding how one cancer dependency, the methyltransferase PRMT5, is regulated in normal biology and cancer. We aim to determine effective sites of PRMT5 inhibition, effective combination therapies with PRMT5, PRMT5 regulation of subcellular processes such as splicing and translation, and PRMT5 crosstalk with cancer immunology. We use structural biology and biochemical interrogation to understand the structure and function of PRMT5 (and other PRMT enzymes).