Sahoo Lab Resources
Human variation and germline interpretation
gnomAD population allele frequencies for filtering germline variants. Now at v4.1, spanning 730,947 exomes and 76,215 genomes on GRCh38.
ClinVar clinical significance of variants.
ClinGen curated gene-disease validity and dosage sensitivity.
OMIM gene-to-phenotype catalog.
Cancer and somatic genomics
cBioPortal visualization and analysis of cancer genomics datasets.
COSMIC catalogue of somatic mutations in cancer.
St. Jude PeCan and ProteinPaint pediatric cancer mutation landscapes and gene-level visualization, directly in your disease space.
DepMap Cancer Dependency Map, CRISPR and RNAi dependencies across cell lines.
CRISPR and genome engineering
CRISPick sgRNA design for knockout, activation, and interference. The legacy GPP sgRNA Designer is retired, and CRISPick is its replacement.
CHOPCHOP guide design with off-target evaluation.
CRISPOR guide selection and off-target scoring.
Addgene nonprofit plasmid repository for CRISPR vectors.
Protein structure and variant effect
AlphaFold Protein Structure Database predicted structures, now with a redesigned interface aligned to the UniProt 2025 release. It also serves AlphaMissense pathogenicity scores, which is useful for germline missense interpretation.
RCSB PDB experimental structures.
UniProt protein sequence, domains, and function.
Single-cell and hematopoiesis expression
CZ CELLxGENE Discover a free platform hosting the largest standardized aggregation of single-cell data, with gene expression, chromatin accessibility, and methylation modalities.
Human Cell Atlas Data Portal curated organ and tissue atlases.
BloodSpot gene expression across normal and malignant hematopoiesis, squarely in your domain.
Human Protein Atlas expression across tissues and cell types.