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Sumita Mishra, Ph.D.

Sumita Mishra, Ph.D.

Assistant Professor

Sumita Mishra, Ph.D.

“Our laboratory is dedicated to elucidating the molecular signaling perturbations associated with metabolic syndrome. By pinpointing and targeting these specific molecular pathways, we are advancing our exploration of potential therapeutic modalities to address this challenging condition.”

 

Exploring the heart of cardiometabolic health: from molecular mechanisms to lifestyle interventions

How might the modulation of metabolic and protein signaling pathways provide therapeutic solutions for cardiometabolic syndromes?

Our heart and metabolism play pivotal roles in our overall health. Central to Dr. Mishra's research is a commitment to understanding cardiometabolic health, with a particular focus on a condition known as Heart Failure with Preserved Ejection Fraction (HFpEF). This prevalent subtype of heart failure originates from complex etiological factors and exhibits diverse clinical phenotypes. Dr. Mishra and her laboratory are dedicated to elucidating the molecular signaling perturbations associated with metabolic syndrome, including HFpEF. By pinpointing and targeting these specific molecular pathways, we are advancing our exploration of potential therapeutic modalities to address this challenging condition.

  • Assistant Professor, Fralin Biomedical Research Institute at VTC
  • Assistant Professor, Department of Human Nutrition, Foods and Exercise, College of Agriculture and Life Sciences

Mishra S, Kass DA. Cellular and molecular pathobiology of heart failure with preserved ejection fraction. Nat Rev Cardiol. 2021 Jun;18(6):400-423. 

Mishra S, Sadagopan N, Dunkerly-Eyring B, Rodriguez S, Sarver DC, Ceddia RP, Murphy SA, Knutsdottir H, Jani VP, Ashok D, Oeing CU, O'Rourke B, Gangoiti JA, Sears DD, Wong GW, Collins S, Kass DA. Inhibition of phosphodiesterase type 9 reduces obesity and cardiometabolic syndrome in mice. J Clin Invest. 2021 Nov 1;131(21):e148798.

Mishra S, Dunkerly-Eyring BL, Keceli G, Ranek MJ. Phosphorylation Modifications Regulating Cardiac Protein Quality Control Mechanisms. Front Physiol. 2020 Nov 12;11:593585. doi: 10.3389/fphys.2020.593585. PMID: 33281625; PMCID: PMC7689282.



Johns Hopkins University School of Medicine, Division of Cardiology, Department of Medicine, Instructor

Johns Hopkins University School of Medicine, Division of Cardiology, Department of Medicine Postdoctoral Fellow

Johns Hopkins University School of Medicine, Division of Pediatric Cardiology, Department of Medicine, Postdoctoral Fellow

  • Research Instructor, Johns Hopkins University School of Medicine
  • Ph.D., Indian Institute of Chemical Biology
  • M.Sc. Biotechnology, Calcutta University
  • B.Sc. Microbiology, Calcutta University
  • W. Leigh Thompson Excellence in Research Award, Basic Science, 2020.
  • AHA Basic Cardiovascular Science Scientific Sessions, Honorable Mention Award, 2019.
  • Stanley Blumenthal award for Best research in Basic science, Institute of Cardiac Science, Division of Cardiology, Johns Hopkins School of Medicine, 2018.
  • Best Presentation- Cyclic Nucleotide PDEs, Gordon Research Conference, 2018.
  • Travel Award, Magee Summit 2018, Pittsburgh, PA, 2018.
  • Future Glycogen leader - Led Johns Hopkins in the Society of Glycobiology meeting at NIH, 2017.
  • Postdoctoral Fellowship award- Glyco-Cardio Fellow, Johns Hopkins School of Medicine, 2016.
  • Travel Award, American Society for Biochemistry and Molecular Biology, Matreya Inc, Pleasant Gap, PA, 2014.
  • University Grant Commission, Council for Scientific and Industrial Research (CSIR) Fellowship,
  • Government of India, 2004-2011.
  • Awarded PhD Deputation, Gwangju Institute of Science and Technology, South Korea, 2007.
  • University 3rd Place in Masters of Genetic Engineering, Calcutta University, 2004.
  • University 3rd Place in Bachelor of Microbiology, Calcutta University, 2002.