Dr. Sassi's Publications

For a more complete list of publications, visit the following publication sites: PubMed

Strauss B, Bisserier M, Obus E, Katz MG, Fargnoli A, Cacheux M, Akar JG, Hummel JP, Hadri L, Sassi Y, Akar FG. Right predominant electrical remodeling in a pure model of pulmonary hypertension promotes reentrant arrhythmias. Heart Rhythm. 2022 Jan;19(1):113-124. doi: 10.1016/j.hrthm.2021.09.021. Epub 2021 Sep 23. PMID: 34563688; PMCID: PMC8742785.

Esfandyari D, Idrissou BMG, Hennis K, Avramopoulos P, Dueck A, El-Battrawy I, Grüter L, Meier MA, Näger AC, Ramanujam D, Dorn T, Meitinger T, Hagl C, Milting H, Borggrefe M, Fenske S, Biel M, Dendorfer A, Sassi Y, Moretti A, Engelhardt S. MicroRNA-365 regulates human cardiac action potential duration. Nat Commun. 2022 Jan 11;13(1):220. doi: 10.1038/s41467-021-27856-7. PMID: 35017523; PMCID: PMC8752767.

Strauss B, Bisserier M, Obus E, Katz MG, Fargnoli A, Cacheux M, Akar JG, Hummel JP, Hadri L, Sassi Y, Akar FG. Right predominant electrical remodeling in a pure model of pulmonary hypertension promotes reentrant arrhythmias. Heart Rhythm. 2021 Sep 23:S1547-5271(21)02195-0. doi: 10.1016/j.hrthm.2021.09.021. Epub ahead of print. PMID: 34563688.

Bisserier M, Katz MG, Bueno-Beti C, Brojakowska A, Zhang S, Gubara S, Kohlbrenner E, Fazal S, Fargnoli A, Dorfmuller P, Humbert M, Hata A, Goukassian DA, Sassi Y, Hadri L. Combination Therapy with STAT3 Inhibitor Enhances SERCA2a-Induced BMPR2 Expression and Inhibits Pulmonary Arterial Hypertension. Int J Mol Sci. 2021 Aug 24;22(17):9105. doi: 10.3390/ijms22179105. PMID: 34502015; PMCID: PMC8431626.

Bisserier M, Mathiyalagan P, Zhang S, Elmastour F, Dorfmüller P, Humbert M, David G, Tarzami S, Weber T, Perros F, Sassi Y, Sahoo S, Hadri L. Regulation of the Methylation and Expression Levels of the BMPR2 Gene by SIN3a as a Novel Therapeutic Mechanism in Pulmonary Arterial Hypertension. Circulation. 2021 Jul 6;144(1):52-73. doi: 10.1161/CIRCULATIONAHA.120.047978. Epub 2021 Jun 3. PMID: 34078089; PMCID: PMC8293289.

Asensio-Lopez MC, Sassi Y, Soler F, Fernandez Del Palacio MJ, Pascual-Figal D, Lax A. The miRNA199a/SIRT1/P300/Yy1/sST2 signaling axis regulates adverse cardiac remodeling following MI. Sci Rep. 2021 Feb 16;11(1):3915. doi: 10.1038/s41598-021-82745-9. PMID: 33594087; PMCID: PMC7887255.

Jones C, Bisserier M, Bueno-Beti C, Bonnet G, Neves-Zaph S, Lee SY, Milara J, Dorfmüller P, Humbert M, Leopold JA, Hadri L, Hajjar RJ, Sassi Y. A novel secreted-cAMP pathway inhibits pulmonary hypertension via a feed-forward mechanism. Cardiovasc Res. 2019 Sep 14.

Magadum A, Kurian AA, Chepurko E, Sassi Y, Hajjar RJ, Zangi L. Specific modified mRNA Translation system. Circulation. 2020 Dec 22;142(25):2485-2488

Bikou O, Hadri L, Hajjar RJ, Sassi Y. Induction and characterization of pulmonary hypertension in mice using the Hypoxia/Sugen model. J Vis Exp. 2020 Jun 3;(160).

Bisserier M, Milara J, Gubara S, Jones C, Bueno-Beti C, Chepurko E, Kohlbrenner E, Katz MG, Fargnoli A, Leopold J, Hajjar RJ, Sassi Y, Hadri L. Targeting molecular mechanisms in experimental and human pulmonary fibrosis. Molecular Therapy. 2020. Feb 5;28(2):394-410.

Bueno-Beti C, Hadri L, Hajjar RJ, Sassi Y. The Sugen 5416/Hypoxia Mouse Model of Pulmonary Arterial Hypertension. Methods Mol Biol. 2018; 1816:243-252. PMID: 29987825.

Magadum A, Singh N, Kurian AA, Munir I, Mehmood T, Brown K, Sharkar MTK, Chepurko E, Sassi Y, Oh JG, Lee P, Santos CXC, Gaziel-Sovran A, Zhang G, Cai CL, Kho C, Mayr M, Shah AM, Hajjar RJ, Zangi L. Pkm2 Regulates Cardiomyocyte Cell Cycle and Promotes Cardiac Regeneration. Circulation. 2020 Apr 14;141(15):1249-1265

Rodriguez P, Sassi Y, Troncone L, Benard L, Ishikawa K, Gordon RE, Lamas S, Laborda J, Hajjar RJ, Lebeche D. Deletion of delta-like 1 homologue accelerates fibroblast-myofibroblast differentiation and induces myocardial fibrosis. Eur Heart J. 2018 Apr 13. PMID: 29668883

Sassi Y, Hulot JS. Pulmonary Hypertension: Novel Pathways and Emerging Therapies Inhibitors of cGMP and cAMP Metabolism. Handb Exp Pharmacol. 2013; 218:513-29.

Mathiyalagan P, Adamiak M, Mayourian J, Sassi Y, Liang Y, Agarwal N, Jha D, Zhang S, Kohlbrenner E, Chepurko E, Chen J, Trivieri MG, Singh R, Bouchareb R, Fish K, Ishikawa K, Lebeche D, Hajjar RJ, Sahoo S. FTO-Dependent m6A Regulates Cardiac Function During Remodeling and Repair. Circulation. 2018 Jul 11. PMID: 29997116

Engelhardt S, Sassi Y. MicroRNA Augmentation of Bone Marrow-Derived Cell Therapy. J Am Coll Cardiol. 2015 Nov 17;66(20):2227-9.

Sassi Y, Lipskaia L, Vandecasteele G, Nikolaev VO, Hatem SN, Cohen Aubart F, Russel FG, Mougenot N, Vrignaud C, Lechat P, Lompré AM, Hulot JS. Multidrug resistance-associated protein 4 regulates cAMP-dependent signaling pathways and controls human and rat SMC proliferation. J Clin Invest. 2008 Aug;118(8):2747-57. PMID: 18636120

Sassi Y, Avramopoulos P, Ramanujam D, Grüter L, Werfel S, Giosele S, Brunner AD, Esfandyari D, Papadopoulou AS, De Strooper B, Hübner N, Kumarswamy R, Thum T, Yin X, Mayr M, Laggerbauer B, Engelhardt S. Cardiac myocyte miR-29 promotes pathological remodeling of the heart by activating Wnt signaling. Nat Commun. 2017 Nov 20;8(1):1614. PMID: 29158499

Sassi Y, Ahles A, Truong DJF, Hulot JS, Baqi Y, Müller C, Husse B, Dendorfer A, Laggerbauer B, Engelhardt S. Cardiac myocyte-secreted cAMP exerts paracrine action via adenosine receptor activation. J Clin Invest. 2014 Dec;124(12):5385-97. PMID: 25401477

Ganesan J, Ramanujam D, Sassi Y, Ahles A, Jentzsch C, Werfel S, Leierseder S, Loyer X, Giacca M, Zentilin L, Thum T, Laggerbauer B, Engelhardt S. MiR-378 controls cardiac hypertrophy by combined repression of mitogen-activated protein kinase pathway factors. Circulation. 2013 May 28;127(21):2097-106. PMID: 23625957

Sassi Y, Abi-Gerges A, Fauconnier J, Mougenot N, Reiken S, Haghighi K, Kranias EG, Marks AR, Lacampagne A, Engelhardt S, Hatem SN, Lompre AM, Hulot JS. Regulation of cAMP homeostasis by the efflux protein MRP4 in cardiac myocytes. FASEB J. 2012 Mar;26(3):1009-17. PMID: 22090316

Hulot JS, Fauconnier J, Ramanujam D, Chaanine A, Aubart F, Sassi Y, Merkle S, Cazorla O, Ouillé A, Dupuis M, Hadri L, Jeong D, Mühlstedt S, Schmitt J, Braun A, Bénard L, Saliba Y, Laggerbauer B, Nieswandt B, Lacampagne A, Hajjar RJ, Lompré AM, Engelhardt S. Critical role for stromal interaction molecule 1 in cardiac hypertrophy. Circulation. 2011 Aug 16;124(7):796-805. PMID: 21810664

Hara Y, Sassi Y, Guibert C, Gambaryan N, Dorfmüller P, Eddahibi S, Lompré AM, Humbert M, Hulot JS. Inhibition of MRP4 prevents and reverses pulmonary hypertension in mice. J Clin Invest. 2011 Jul;121(7):2888-97. PMID: 21670499

Sassi Y, Lipskaia L, Vandecasteele G, Nikolaev VO, Hatem SN, Cohen Aubart F, Russel FG, Mougenot N, Vrignaud C, Lechat P, Lompré AM, Hulot JS. Multidrug resistance-associated protein 4 regulates cAMP-dependent signaling pathways and controls human and rat SMC proliferation. J Clin Invest. 2008 Aug;118(8):2747-57. PMID: 18636120