Grace Blair's Dissertation Defense (4/18/2023): Investigating the Coordination of Cardiac Conduction and Repolarization in Ventricular Myocardium
More About the Candidate and Project
Virginia Tech, Translational Biology, Medicine, and Health, Ph.D. Candidate
University of North Carolina - Chapel Hill, B.S., Biology
Graduate Research Assistant, Poelzing Lab, Fralin Biomedical Research Instittue at VTC
Steven Poelzing, Ph.D., Professor, Fralin Biomedical Research Institute, Co-Director, Translational Biology, Medicine, and Health Graduate Program
- John Chappell, Ph.D., Associate Professor, Fralin Biomedical Research Institute at VTC
- Robert Gourdie, Ph.D., Professor, Director, Center for Vascular and Heart Research, Fralin Biomedical Research Institute at VTC
- Sunshine Lahmers, DVM, Ph.D., Clinical Associate Professor, Virginia-Maryland College of Veterinary Medicine
- Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship F31. Unmasking Conduction Deficits in the Scn5a+/- Mouse Model of Brugada Syndrome - 2021-2023
Grace Blair, Xiaobo Wu, Chandra B. Bain, Gregory Hoeker, Steve Poelzing. Mannitol and hyponatremia regulate cardiac ventricular conduction in the context of sodium channel loss of function. Manuscript submitted for publication.
Grace Blair, Madeline Depman, William Adams, Elina Baltins, Greg Hoeker, Seth Weinberg, Steve Poelzing. Sequence-Dependent Repolarization in Ventricular Myocardium is More Dependent on Endogenous APD Gradients than Electrical Coupling. Manuscript submitted for publication.
Tristan B. Raisch PhD, William P. Adams, Yajun Zhao PhD, Rafael Davalos PhD, Sarah Barrett DVM, PhD, DACVP4, D. Ryan King PhD, Chandra B. Bain, Katrina Colucci-Chang, Grace A. Blair, Rengasayee Veeraraghavan PhD, Xiaoping Wan MD,PhD, Isabelle Deschenes PhD, James W. Smyth PhD, Gregory S. Hoeker PhD, Robert G. Gourdie PhD, Steven Poelzing PhD. Extracellular perinexal separation is a principal determinant of cardiac conduction. Manuscript in review.
Rachel L. Padget, Grace A. Blair, Michael D. North, Michael J. Zeitz, Mira T. Tanenbaum, D. Ryan King, Gregory S. Hoeker, Sharon A. Swanger, Steven Poelzing, James W. Smyth. Acute adenoviral cardiac infection elicits an arrhythmogenic substrate prior to inflammatory myocardial remodeling and myocarditis. bioRxiv 2022.11.29.518421; doi: https://doi.org/10.1101/2022.11.29.518421
Lin J, Abraham A, George SA, Greer-Short A, Blair GA, Moreno A, Alber BR, Kay MW, Poelzing S. Ephaptic Coupling Is a Mechanism of Conduction Reserve During Reduced Gap Junction Coupling. Front Physiol. 2022 May 5; 13:848019. PMID: 35600295.
Wu X, Hoeker GS, Blair GA, King DR, Gourdie RG, Weinberg SH, Poelzing S. Hypernatremia and intercalated disc edema synergistically exacerbate long-QT syndrome type 3 phenotype. Am J Physiol Heart Circ Physiol. 2021 Dec 1; 321(6):H1042-H1055. PMID: 34623182.
King DR, Entz M 2nd, Blair GA, Crandell I, Hanlon AL, Lin J, Hoeker GS, Poelzing S. The conduction velocity-potassium relationship in the heart is modulated by sodium and calcium. Pflugers Arch. 2021 Mar;473(3):557-571. PMID: 33660028.