Kathleen Mulvaney, Ph.D.
Exploring cellular communication to find cancer treatments
What can understanding protein-protein interactions tell us about how cancers develop and grow?
Kathleen Mulvaney's long-standing research focus is understanding and disrupting protein-protein interactions and protien modifications in cancer, and translating that knowledge into meaningful clinical improvements for patient care. Some enzymes show altered gene expression or activity in cancer or become a genetic requirement/dependency that the tumor relies on for survival. Dr. Mulvaney seeks to identify and characterize these dependencies in cancers of the pancrease and pediatric and adult brain cancers. Understanding what a tumor requires to survive may provide a pathway to killing it.
- Assistant Professor, Fralin Biomedical Research Institute at VTC
- Assistant Professor, Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine
Mulvaney, KM; Bozal, FK; Sellers, WR. Monitoring and disrupting cellular PRMT5-substrate adaptor complex formation in in-tact and permeabilized cells using a split luciferase complementation assay. STAR Protocols, Cell Press. Manuscript in preparation.
Mulvaney, KM; Blomquist, C; Acharya, N; Li, R; Ranaghan, MJ; O’Keefe, M; Rodriguez, DJ; Young, MJ; Kesar, D; Pal, D; Stokes, M; Nelson, AJ; Jain, SS; Yang, A; Mullin-Bernstein, Z; Columbus, J; Bozal, FK; Skepner, A; Raymond, D; … Sellers, WR. Molecular basis for substrate recruitment to the PRMT5 methylosome. Molecular Cell. 2021, 81(17)17, P3481-3495.
McKinney, DC; McMillan, BJ; Ranaghan, MJ; Moroco, JA; Brousseau, M; Mullin-Bernstein, Z; O’Keefe, M; McCarren, P; Mesleh, M; Mulvaney, KM; Robinson, F; Singh, R; Bajrami, B; Wagner, FF; Hilgraf, R; Drysdale, MJ; Campbell, AJ; Skepner, A; Timm, DE; Porter, D; Kaushik, VK; Sellers, WR; Ianari, A. Discovery of a First-in-Class Inhibitor of the PRMT5–Substrate Adaptor Interaction. Journal of Medicinal Chemistry. 2021, 64 (15), 11148-11168. PMID:34342224.
Tamir*, TY; Mulvaney, KM*; M. Ben Major. Dissecting the Keap1/Nrf2 pathway through
proteomics. Curr. Opin. Toxicol. 2, (2017). https://doi.org/10.1016/j.cotox.2016.10.007. (*equal contribution)
Mulvaney, KM.; Matson, J.; Siesser, P.; Tamir, TY; Goldfarb, D.; Jacobs, T.; Cloer, EW; Cook, JG; Major, MB. Identification and Characterization of MCM3 as a KEAP1 Substrate. Journal of Biological Chemistry, 2016 Nov 4; 291(45): 23719–23733.
The Broad Institute; Dana Farber Cancer Institute, Cambridge, Mass., Postdoctoral Fellow
University of North Carolina, Chapel Hill, Graduate Student
Dana Farber Cancer Institute, Harvard University, Research Assistant
- University of North Carolina, Chapel Hill, Ph.D., Cell Biology
- University of Rochester, B.S., Biology
- National Institutes of Health F32 Ruth L. Kirschstein Postdoctoral Individual National Research Service Award (2018-2021)
- National Institutes of Health LRP Award (2019-2021)
- Sigma Xi Research Society Graduate Student Travel Award (2015)
- National Science Foundation Graduate Research Fellowship Honorable Mention (2011, 2012)
- Degree with Distinction in Research: an honor awarded by the University of Rochester (2009)
- National Science Foundation David T. Kearns Scholar (2008-2010)
- Take Five Scholar: Awarded tuition-free fifth year by the University of Rochester to study “Influences on Cognitive and Personality Development” (2009- 2010)
- Academic Competitiveness Grant awarded by New York State (2007- 2008)
- International Baccalaureate Scholar awarded as a four-year merit scholarship (2005- 2009)