Led by principal investigator Junco Warren, Ph.D., the Warren Lab studies the mechanisms underlying metabolic reprogramming in the failing heart. In particular, the lab is interested in identifying the key regulators that orchestrate metabolic remodeling under pathological stress, such as a high blood pressure or loss of heart muscle due to myocardial infarction. A particular focus of the lab is the switch from compensated to the decompensated stage during this progressive disease. The conceptual mechanisms of this pivotal event remain largely unknown. Using a multi-systems view of metabolism regulation, combining multiple–omics techniques with precise delineation of specific regulatory circuits, the lab aims to decode the heart's compensatory mechanisms and why they eventually fail.
If you are interested in multidisciplinary questions at the interface of cardiac energy and function, gene regulation, and intervention with nutrition, please contact us, we would love to add you to our group!
- Junichi Sadoshima, M.D., Ph.D., Professor and Chair, Cell Biology & Molecular Medicine, Rutgers New Jersey Medical School
- Stavros G. Drakos, M.D., Ph.D., Professor, Internal Medicine, University of Utah
- Shinichi Oka, Ph.D., Assistant Professor, Cell Biology & Molecular Medicine, Rutgers New Jersey Medical School
- Anandh Babu Pon Velayutham, Ph.D., Associate Professor, Nutrition and Integrative Physiology, University of Utah
- Masayuki Yazawa, Ph.D., Associate Professor, Rehabilitation and Regenerative Medicine, Columbia University
- Yukio Saijoh, Ph.D., Research Associate, University of Utah
- Yuichi Oike, M.D., Ph.D., Professor, Molecular Genetics, Kumamoto University, Japan