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Warren Lab

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Led by principal investigator Junco Warren, Ph.D., the Warren Lab studies the mechanisms underlying metabolic reprogramming in the failing heart. In particular, the lab is interested in identifying the key regulators that orchestrate metabolic remodeling under pathological stress, such as a high blood pressure or loss of heart muscle due to myocardial infarction. A particular focus of the lab is the switch from compensated to the decompensated stage during this progressive disease. The conceptual mechanisms of this pivotal event remain largely unknown. Using a multi-systems view of metabolism regulation, combining multiple–omics techniques with precise delineation of specific regulatory circuits, the lab aims to decode the heart's compensatory mechanisms and why they eventually fail.

If you are interested in multidisciplinary questions at the interface of cardiac energy and function, gene regulation, and intervention with nutrition, please contact us, we would love to add you to our group! 

Meet the Lab

 

 

Collaborators

 

Undergraduate Student Volunteers

Shreya Yedla

Shreya Yedla
Biomedical Engineering and Mechanics, College of Engineering, Virginia Tech

Amina James

Amina James
Human Nutrition, Foods, and Exercise, College of Agriculture and Life Sciences, Virginia Tech

Lab Alumni

Dane Barton, M.D.

Dane Barton, M.D.
Research Assistant

Keiko Cawley

Keiko Cawley, B.S.
Research Assistant

Amira Sabry

Amira Sabry
Research Assistant

Amanda Horiuchi

Amanda Horiuchi, B.S.
Research Assistant

Maria (Masha) Zaitsev

Maria (Masha) Zaitsev
Summer Student

Sean O'Very

Sean O'Very, B.S.
Research Assistant