In Person Lecture: Human Cardiac Metabolism
Zoltan Arany, M.D., Ph.D.
Samuel Bellet Professor of Cardiology
Co-Director, Cardiovascular Division
Institute for Diabetes, Obesity & Metabolism
Perelman School of Medicine
University of Pennsylvania
Timothy A. Johnson Medical Scholar Lecture: Human Cardiac Metabolism
About this Seminar
Heart failure is understood to be in part a metabolic disorder, but most of our understanding of cardiac metabolism stems from pre-clinical models. Dr. Arnay and his lab therefore leveraged modern mass spectrometry and metabolomics to probe cardiac metabolism in human health and disease in two contexts: (1) arteriovenous differences in plasma metabolite concentrations across the cardiac microvasculature in 120 patients undergoing elective procedures requiring placement of a coronary sinus catheter, and (2) tissue samples from excised hearts from patients undergoing transplantation for non-ischemic dilated cardiomyopathy or from organ donors with normal cardiac function. From the former, the lab calculated flux of hundreds metabolites in and out of the heart in health and disease, while from the latter researchers gathered mechanistic insight into metabolic alterations in heart failure.
Additional Details
This is a free event hosted by the Fralin Biomedical Research Institute and the Virginia Tech Carilion School of Medicine. The Timothy A. Johnson Medical Scholar Lecture Series hosts clinician scientists who are exploring frontiers of medicine. These lectures are principally intended for Virginia Tech Carilion School of Medicine students and Virginia Tech students in the Translational Biology, Medicine, and Health graduate program. Virginia Tech and Carilion Clinic faculty, staff, and students may also attend.
You May Also Be Interested In...
-
Home Item
Policies to Reduce Ultra-processed Foods: Lessons From Around the Globe , homeJan. 30, 2026, 11:00 a.m. | Lindsey Smith Taillie, Ph.D., MPH, Associate Professor of Nutrition, Associate Chair of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill | Co-Sponsored by the Fralin Biomedical Research Institute Center for Health Behaviors Research and Addiction Recovery Research Center
-
Home Item
AI and Agentic AI: Opportunities for How We Work, Care, Discover, and Share , homeFeb. 5, 2026, 5:30 p.m. (Reception at 5 p.m.) | Vivian S. Lee, M.D., Ph.D., M.B.A., Executive Fellow, Harvard Business School; Senior Lecturer, Harvard Medical School; Elected Member, National Academy of Medicine | Maury Strauss Distinguished Public Lecture
-
Home Item
Early Childhood Brain Development and Risk for Schizophrenia , homeFeb. 13, 2026, 11 a.m. | John Gilmore, M.D., Eure Distinguished Professor and Vice Chair for Research, Department of Psychiatry, University of North Carolina School of Medicine | Co-Sponsored by the Fralin Biomedical Research Institute Center for Human Neuroscience Research
-
Home Item
Is It What You Eat or When You Eat? Evidence for Time Restricted Eating in Humans , homeFeb. 27, 2026, 11:00 a.m. | Lisa Chow, M.D., Professor of Medicine, Pennock Family Land Grant Chair in Diabetes Research, University of Minnesota | Co-Sponsored by the Fralin Biomedical Research Institute Center for Exercise Medicine Research
-
Home Item
A Nicotine-Focused Regulatory Strategy: The Science , homeMarch 13, 2026, 11:00 a.m. | Dorothy Hatsukami, Ph.D., Professor of Psychiatry and Behavioral Sciences and Forster Family Chair in Cancer Prevention, Masonic Cancer Center, University of Minnesota | Co-Sponsored by the Fralin Biomedical Research Institute Cancer Research Center – Roanoke
-
Home Item
From BDNF to Rett Syndrome: Synapses, Networks, and Social Behaviors in Mecp2 Mutant Mice , homeMarch 27, 2026, 11:00 a.m. | Lucas Pozzo-Miller, Ph.D., Mall Family Endowed Professor for Genetic Autism Research, Department of Pediatrics & Human Development, College of Medicine, Michigan State University | Co-Sponsored by the Fralin Biomedical Research Institute Center for Neurobiology Research