Virginia Tech® home

In Person Lecture: Pathways to Psychosis: Integrating Rare and Common Variants Approaches

Insert your title here

Your Text Here
Raquel Gur, M.D., Ph.D.

Raquel Gur, M.D., Ph.D.

Karl and Linda Rickels Professor of Psychiatry
Vice Chair for Research Development
Director of Neuropsychiatry Section
University of Pennsylvania

Timothy A. Johnson Medical Scholar Lecture: Pathways to Psychosis: Integrating Rare and Common Variants Approaches

April 14, 2023

1 to 2 p.m.

View Speaker Profile
Download Flyer

About this Seminar

Heterogeneity of the genetic architecture of psychosis implicates both common and rare genetic variants, the former allowing generation of polygenic risk scores (PRS) that confer small effect sizes, while the latter can help identify rare variants with large effect size that can point to more specific mechanisms. Together they may enhance discovery of biomarkers for early identification and intervention. The seminar will first highlight multimodal lines of research examining the psychosis dimension in the population at large and in 22q11.2 deletion syndrome (22qDS) that confers a 25-fold increased risk for psychosis. Topics reviewed will include clinical presentation and course, neurobehavioral functions, and multimodal neuroimaging. Dr. Gur will then focus on 22qDS as a translational window to advance underlying biology and therapeutics. Rodent models probing neurobehavioral domains impacted in humans and iPSC investigations will be highlighted. The final part will discuss challenges and promises of such convergent efforts with special emphasis for Medical Scholars.

 

Additional Details

This is a free event hosted by the Fralin Biomedical Research Institute and the Virginia Tech Carilion School of Medicine. The Timothy A. Johnson Medical Scholar Lecture Series hosts clinician scientists who are exploring frontiers of medicine. These lectures are principally intended for Virginia Tech Carilion School of Medicine students and Virginia Tech students in the Translational Biology, Medicine, and Health graduate program. Virginia Tech and Carilion Clinic faculty, staff, and students may also attend.

fbri logo

You May Also Be Interested In...

  • Home Item
    Sudden Cardiac Arrest in the Young: The Case of ARVC
    Sudden Cardiac Arrest in the Young: The Case of ARVC , home

    Oct. 18, 2024, 11:00 a.m. | Mario Delmar, M.D., Ph.D., Endowed Professor of Medicine, Patricia and Robert Martinsen Professor of Cardiology, Leon H Charney Division of Cardiology, New York University School of Medicine | Pioneers in Biomedical Research Seminar, Co-Sponsored by the Fralin Biomedical Research Institute Center for Vascular and Heart Research

  • Home Item
    Harnessing Interoception: Innovative Approaches for Psychiatric Assessment and Intervention
    Harnessing Interoception: Innovative Approaches for Psychiatric Assessment and Intervention , home

    Oct. 25, 2024, 11:00 a.m. | Sahib Khalsa, M.D., Ph.D., Associate Professor, Louis Jolyon West Innovation Chair, Director of Anxiety Disorders Research, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles| Co-Sponsored by the Center for Health Behaviors Research and the Addiction Recovery Research Center, Fralin Biomedical Research Institute

  • Home Item
    Clinical Applications of Cancer Genetics
    Clinical Applications of Cancer Genetics , home

    Nov. 21, 2024, 5:30 p.m. (Reception at 5 p.m.) | Luis Diaz, Jr., M.D., Head, Division of Solid Tumor Oncology, Memorial Sloan Kettering Cancer Center; Member, National Academy of Medicine | Maury Strauss Distinguished Public Lecture

  • Home Item
    A Ribocentric View of Muscle Proteostasis in Health and Disease: Novel Mechanisms Potential Therapeutic Opportunities
    A Ribocentric View of Muscle Proteostasis in Health and Disease: Novel Mechanisms Potential Therapeutic Opportunities , home

    Nov. 22, 2024, 11:00 a.m. | Gustavo A. Nader, Ph.D., FAPS, Professor, College of Health and Human Development; Chair, Molecular, Cellular, and Integrative Physiology; Huck Institutes of the Life Sciences; The Pennsylvania State University | Co-Sponsored by the Fralin Biomedical Research Institute Center for Exercise Medicine Research

  • Home Item
    Human Laboratory Evaluation of Cannabis Products
    Human Laboratory Evaluation of Cannabis Products , home

    Dec. 13, 2024, 11:00 a.m. | Ryan Vandrey, Ph.D., Professor, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine | Co-Sponsored by the Fralin Biomedical Research Institute Center for Health Behaviors Research and the Addiction Recovery Research Center

  • Home Item
    Mechanics of Convective Cell Motion
    Mechanics of Convective Cell Motion , home

    Jan. 10, 2025, 11:00 a.m. | Michael Murrell, Ph.D., Associate Professor, Department of Biomedical Engineering and Physics, Yale University | Co-Sponsored by the Fralin Biomedical Research Institute Cancer Research Center – Roanoke