Insights into Arrhythmia Mechanisms and Therapies from Cardiac Reprogramming
Stacey Rentschler, M.D., Ph.D.
Associate Professor of Medicine
John T. Millken Department of Internal Medicine
Cardiovascular Division
Washington University School of Medicine in St. Louis
Timothy A. Johnson Medical Scholar Lecture: Insights into Arrhythmia Mechanisms and Therapies from Cardiac Reprogramming
About this Seminar
Research efforts in the Rentschler lab center on defining the transcriptional and epigenetic mechanisms underlying arrhythmias through studying cardiac physiology and regulation of gene expression in murine, porcine and human model systems. Dr. Rentschler’s group has previously demonstrated that reactivation of developmental signaling pathways including Notch and Wnt can electrically remodel cardiomyocytes, or “reprogram” them, to adopt a new electrical phenotype in animal models. In the atria, Notch activation in response to pressure overload regulates a distinct transcriptional signature in the right versus left atrium and may predispose to atrial fibrillation. In contrast, Notch regulates a distinct transcriptional response in adult ventricular cardiomyocytes resulting in reprogramming to a Purkinje-like phenotype. Noninvasive radiation therapy is a novel treatment for ventricular tachycardia, and the lab recently demonstrated that a single high dose of radiation temporarily activates Notch signaling and results in long-term reprogramming of cardiac conduction in normal and diseased hearts. The lab’s work aims to translate insights learned through the study of basic mechanisms of gene expression into novel therapies for arrhythmia.
Additional Details
This is a free event hosted by the Fralin Biomedical Research Institute and the Virginia Tech Carilion School of Medicine. The Timothy A. Johnson Medical Scholar Lecture Series hosts clinician scientists who are exploring frontiers of medicine. These lectures are principally intended for Virginia Tech Carilion School of Medicine students and Virginia Tech students in the Translational Biology, Medicine, and Health graduate program. Virginia Tech and Carilion Clinic faculty, staff, and students may also attend.
You May Also Be Interested In...
-
Home ItemThinking the Right Thoughts , home
Nathaniel Daw, Ph.D., Professor, Computational and Theoretical Neuroscience, Department of Psychology, Princeton University | Co-Sponsored by the Fralin Biomedical Research Institute Center for Human Neuroscience Research
-
Home ItemThe Emergence of Network Activity Patterns - An Early Window to Autism Spectrum Disorder , home
March 14, 2025, 11:00 a.m. | Natalia De Marco Garcia, Ph.D., Associate Professor, Department of Neuroscience, The Brain and Mind Research Institute, Weill Cornell Medical College | Co-Sponsored by the Center for Neurobiology Research, Fralin Biomedical Research Institute
-
Home ItemIntegration of Sensory, Metabolic and Neural Signals in the Determination of Food Choices and How Dysregulation of These Systems Contributes to Obesity, Diabetes and Cognitive Impairment , home
March 21, 2025, 11:00 a.m. | Dana M. Small, Ph.D., Professor, Department of Psychiatry and Psychology, Director, Modern Diet and Physiology Research Center, Yale School of Medicine | Co-Sponsored by the Center for Health Behaviors Research and the Addiction Recovery Research Center, Fralin Biomedical Research Institute
-
Home ItemSocial Learning in Borderline Personality Disorder , home
April 4, 2025, 11:00 a.m. | Sarah Fineberg, M.D., Ph.D., Assistant Professor, Department of Psychiatry, Yale School of Medicine | Co-Sponsored by the Fralin Biomedical Research Institute Center for Human Neuroscience Research
-
Home ItemBringing Precision Medicine to Psychiatry , home
April 10, 2025, 5:30 p.m. (Reception at 5 p.m.) | Jordan Smoller, M.D., Sc.D., MGH Trustees Endowed Chair in Psychiatric Neuroscience; Professor of Psychiatry, Harvard Medical School; Professor of Epidemiology, T.H. Chan Harvard School of Public Health; Director, Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital | Maury Strauss Distinguished Public Lecture
-
Home ItemExtracellular Vesicles in the Pathogenesis, Diagnosis and Treatment of the Heart , home
April 11, 2025, 11:00 a.m. | Susmita Sahoo, Ph.D., Associate Professor, Department of Medicine and Cardiology, Icahn School of Medicine at Mount Sinai | Co-Sponsored by the Fralin Biomedical Research Institute Center for Vascular and Heart Research