Insights into Arrhythmia Mechanisms and Therapies from Cardiac Reprogramming
Stacey Rentschler, M.D., Ph.D.
Associate Professor of Medicine
John T. Millken Department of Internal Medicine
Cardiovascular Division
Washington University School of Medicine in St. Louis
Timothy A. Johnson Medical Scholar Lecture: Insights into Arrhythmia Mechanisms and Therapies from Cardiac Reprogramming
About this Seminar
Research efforts in the Rentschler lab center on defining the transcriptional and epigenetic mechanisms underlying arrhythmias through studying cardiac physiology and regulation of gene expression in murine, porcine and human model systems. Dr. Rentschler’s group has previously demonstrated that reactivation of developmental signaling pathways including Notch and Wnt can electrically remodel cardiomyocytes, or “reprogram” them, to adopt a new electrical phenotype in animal models. In the atria, Notch activation in response to pressure overload regulates a distinct transcriptional signature in the right versus left atrium and may predispose to atrial fibrillation. In contrast, Notch regulates a distinct transcriptional response in adult ventricular cardiomyocytes resulting in reprogramming to a Purkinje-like phenotype. Noninvasive radiation therapy is a novel treatment for ventricular tachycardia, and the lab recently demonstrated that a single high dose of radiation temporarily activates Notch signaling and results in long-term reprogramming of cardiac conduction in normal and diseased hearts. The lab’s work aims to translate insights learned through the study of basic mechanisms of gene expression into novel therapies for arrhythmia.
Additional Details
This is a free event hosted by the Fralin Biomedical Research Institute and the Virginia Tech Carilion School of Medicine. The Timothy A. Johnson Medical Scholar Lecture Series hosts clinician scientists who are exploring frontiers of medicine. These lectures are principally intended for Virginia Tech Carilion School of Medicine students and Virginia Tech students in the Translational Biology, Medicine, and Health graduate program. Virginia Tech and Carilion Clinic faculty, staff, and students may also attend.
You May Also Be Interested In...
-
Home ItemIn Person at CNRIC: Hyperactivation of an RNA Binding Protein by Cancer-associated Mutations , home
April 19, 11:00 a.m., Collaboratory, Children's National Research and Innovation Campus, Washington, D.C. | Daniel Dominguez, Ph.D., Assistant Professor, Pharmacology, UNC School of Medicine | Co-Sponsored by the Fralin Biomedical Research Institute Cancer Research Center (DC)
-
Home ItemIn Person Seminar: Our Mass Spectrometry Screening Studies in the Mouse and Human Hearts in Health and Disease , home
April 26, 2024, 11 a.m. | Anthony Gramolini, Ph.D., Professor, Physiology and Translational Biology and Engineering, Ted Rogers Centre for Heart Research, University of Toronto | Co-Sponsored by the Fralin Biomedical Research Institute Center for Vascular and Heart Research
-
Home ItemIn Person Seminar: Regulation of Mitochondrial Parameters in Skeletal Muscle , home
May 3, 2024, 11:00 a.m. | Glenn Rowe, Ph.D., Associate Professor of Medicine, Division of Cardiovascular Disease, University of Alabama at Birmingham | Co-Sponsored by the Fralin Biomedical Research Institute Center for Exercise Medicine Research
-
Home ItemPlanning the Future of Environmental Health Sciences , home
May 9, 2024, 5:30 p.m. (Reception at 5 p.m.) | Rick Woychik, Ph.D., Director, National Institute of Environmental Health Sciences, National Institutes of Health | Maury Strauss Distinguished Public Lecture
-
Home ItemIn Person Seminar: Flavors in Tobacco and Nicotine Products: Science-based Regulation , home
May 10, 2024, 11:00 a.m. | Suchitra Krishnan-Sarin, Ph.D., Albert E. Kent Professor of Psychiatry, Yale School of Medicine | Co-Sponsored by the Fralin Biomedical Research Institute Center for Health Behaviors Research and the Addiction Recovery Research Center
-
Home ItemCANCELLED: In Person Seminar: Sex Influences on Brain and Body: An Issue That is Here to Stay , home
May 17, 2024, 11:00 a.m. | Larry Cahill, Ph.D., Professor, Neurobiology and Behavior, University of California, Irvine | Co-Sponsored by the Fralin Biomedical Research Institute Center for Human Neuroscience Research