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Exercise-induced skeletal muscle EcSOD in disease protection

Exercise training is the most effective intervention against numerous diseases, including cancer, cardiovascular, metabolic and neurodegenerative diseases; however, the underlying mechanisms are not fully understood. The Yan Lab has obtained data to show that a secreted antioxidant protein, extracellular superoxide dismutase (EcSOD), is highly induced in skeletal muscle by endurance exercise training. The team hypothesizes that endurance exercise training-induced EcSOD expression in skeletal muscle provides protection against oxidative damage in skeletal muscle and other peripheral tissues/organs against various disease conditions. The lab is specifically interested in the roles of endurance exercise training-induced EcSOD expression in protection against catabolic muscle wasting, diabetic cardiomyopathy and multiple organ dysfunction syndrome induced by endotoxemia, sepsis and trauma. The findings will provide novel insights into the moledular mechanism by which regular exercise elicits profound protection against many other disease conditions, such as diabetes, atherosclerosis, heart failure and peripheral arterial disease.


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Yan Z, Spaulding HR. Extracellular superoxide dismutase, a molecular transducer of health benefits of exercise. Redox Biol. 2020 Mar 19;32:101508. doi: 10.1016/j.redox.2020.101508. [Epub ahead of print] Review. PubMed PMID: 32220789; PubMed Central PMCID: PMC7109453.