In Person Lecture: Human Cardiac Metabolism
Zoltan Arany, M.D., Ph.D.
Samuel Bellet Professor of Cardiology
Co-Director, Cardiovascular Division
Institute for Diabetes, Obesity & Metabolism
Perelman School of Medicine
University of Pennsylvania
Timothy A. Johnson Medical Scholar Lecture: Human Cardiac Metabolism
About this Seminar
Heart failure is understood to be in part a metabolic disorder, but most of our understanding of cardiac metabolism stems from pre-clinical models. Dr. Arnay and his lab therefore leveraged modern mass spectrometry and metabolomics to probe cardiac metabolism in human health and disease in two contexts: (1) arteriovenous differences in plasma metabolite concentrations across the cardiac microvasculature in 120 patients undergoing elective procedures requiring placement of a coronary sinus catheter, and (2) tissue samples from excised hearts from patients undergoing transplantation for non-ischemic dilated cardiomyopathy or from organ donors with normal cardiac function. From the former, the lab calculated flux of hundreds metabolites in and out of the heart in health and disease, while from the latter researchers gathered mechanistic insight into metabolic alterations in heart failure.
Additional Details
This is a free event hosted by the Fralin Biomedical Research Institute and the Virginia Tech Carilion School of Medicine. The Timothy A. Johnson Medical Scholar Lecture Series hosts clinician scientists who are exploring frontiers of medicine. These lectures are principally intended for Virginia Tech Carilion School of Medicine students and Virginia Tech students in the Translational Biology, Medicine, and Health graduate program. Virginia Tech and Carilion Clinic faculty, staff, and students may also attend.
You May Also Be Interested In...
-
Home Item
In Person Seminar: Win to Fight and Lose to Flight: Innate Yet Flexible Aggression Circuit , homeMarch 24, 2023, 11 a.m. | Dayu Lin, Ph.D., Professor, Department of Psychiatry, Grossman School of Medicine, New York University | Pioneers in Biomedical Research Seminar Series | Co-Sponsored by the Fralin Biomedical Research Institute Center for Neurobiology Research
-
Home Item
Seminar: Signaling and Metabolic Control of Nucleotide Metabolism in Cancer , homeMarch 27, 2023, 11 a.m. | Eunus S. Ali, Ph.D., Postdoctoral Associate, Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University | Seminar
-
Home Item
In Person Seminar: Quantifying Diverse Research Representation , homeMarch 31, 2023, 11:00 a.m. | Jonathan Jackson, Ph.D., Executive Director, Community Access, Recruitment, and Engagement (CARE) Research Center, Harvard University and Massachusetts General Hospital | Pioneers in Biomedical Research Seminar Series | Co-Sponsored by the Fralin Biomedical Research Institute Center for Human Neuroscience Research
-
Home Item
In Person Lecture: Synaptic Injury: A Link to the Past , homeMarch 31, 2023, 1 p.m. | Terrance Kummer, M.D., Ph.D., Associate Professor of Neurology, Washington University School of Medicine in St. Louis | Timothy A. Johnson Medical Scholar Lecture Series
-
Home Item
Seminar: Understanding Cancer: From Development to Therapy , homeApril 5, 2023, 11 a.m. | Biplab Dasgupta, M.S., Ph.D., MBA, Professor of Pediatrics, Division of Oncology, Cincinnati Children's Hospital | Seminar
-
Home Item
In Person Seminar: Brain Dynamics and Flexible Behaviors , homeApril 14, 2023, 11:00 am. | Lucina Q. Uddin, Ph.D., Professor in Residence, Department of Psychiatry and Biobehavioral Science, University of California, Los Angeles | Pioneers in Biomedical Research Seminar Series | Co-Sponsored by the Fralin Biomedical Research Institute Addiction Recovery Research Center and Center for Health Behaviors Research