In Person Lecture: Human Cardiac Metabolism
Zoltan Arany, M.D., Ph.D.
Samuel Bellet Professor of Cardiology
Co-Director, Cardiovascular Division
Institute for Diabetes, Obesity & Metabolism
Perelman School of Medicine
University of Pennsylvania
Timothy A. Johnson Medical Scholar Lecture: Human Cardiac Metabolism
About this Seminar
Heart failure is understood to be in part a metabolic disorder, but most of our understanding of cardiac metabolism stems from pre-clinical models. Dr. Arnay and his lab therefore leveraged modern mass spectrometry and metabolomics to probe cardiac metabolism in human health and disease in two contexts: (1) arteriovenous differences in plasma metabolite concentrations across the cardiac microvasculature in 120 patients undergoing elective procedures requiring placement of a coronary sinus catheter, and (2) tissue samples from excised hearts from patients undergoing transplantation for non-ischemic dilated cardiomyopathy or from organ donors with normal cardiac function. From the former, the lab calculated flux of hundreds metabolites in and out of the heart in health and disease, while from the latter researchers gathered mechanistic insight into metabolic alterations in heart failure.
Additional Details
This is a free event hosted by the Fralin Biomedical Research Institute and the Virginia Tech Carilion School of Medicine. The Timothy A. Johnson Medical Scholar Lecture Series hosts clinician scientists who are exploring frontiers of medicine. These lectures are principally intended for Virginia Tech Carilion School of Medicine students and Virginia Tech students in the Translational Biology, Medicine, and Health graduate program. Virginia Tech and Carilion Clinic faculty, staff, and students may also attend.
You May Also Be Interested In...
-
Home Item
Pandemics — The Lessons I've Learned , homeNov. 6, 2025, 5:30 p.m. (Reception at 5 p.m.) | Teresa Lambe, Ph.D., OBE, Calleva Head of Vaccine Immunology, Professor of Vaccinology and Immunology, University of Oxford | Maury Strauss Distinguished Public Lecture
-
Home Item
Understanding Vascular Morphogenesis and Morphology: Live Insights from Zebrafish , homeNov. 21, 2025, 11:00 a.m. | Arndt F. Siekmann, Ph.D., Associate Professor, Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania | Co-Sponsored by the Center for Vascular and Heart Research, Fralin Biomedical Research Institute
-
Home Item
The Metabolic Switch in Development and Degeneration , homeDec. 12, 2025, 11:00 a.m. | Elizabeth Jonas, M.D., Harvey and Kate Cushing Professor of Internal Medicine (Endocrinology), Yale School of Medicine | Co-Sponsored by the Fralin Biomedical Research Institute Center for Neurobiology Research
-
Home Item
Innovative Strategies for Overcoming Challenges in Brain Tumor Treatment , homeJan. 16, 2026, 11:00 a.m. | Kristin Huntoon, Ph.D., D.O., Assistant Professor, Department of Neurosurgery, University of Arizona | Co-Sponsored by the Fralin Biomedical Research Institute Cancer Research Center – Roanoke
-
Home Item
Maury Strauss Distinguished Public Lecture , homeJan. 22, 2026, 5:30 p.m. (Reception at 5 p.m.) | Holly Ingraham, Ph.D., Professor, Cellular and Molecular Pharmacology; Elected Member, National Academy of Sciences | Maury Strauss Distinguished Public Lecture
-
Home Item
Policies to Reduce Ultra-processed Foods: Lessons From Around the Globe , homeJan. 30, 2026, 11:00 a.m. | Lindsey Smith Taillie, Ph.D., MPH, Associate Professor of Nutrition, Associate Chair of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill | Co-Sponsored by the Fralin Biomedical Research Institute Center for Health Behaviors Research and Addiction Recovery Research Center