Insights into Arrhythmia Mechanisms and Therapies from Cardiac Reprogramming
Stacey Rentschler, M.D., Ph.D.
Associate Professor of Medicine
John T. Millken Department of Internal Medicine
Washington University School of Medicine in St. Louis
Timothy A. Johnson Medical Scholar Lecture: Insights into Arrhythmia Mechanisms and Therapies from Cardiac Reprogramming
About this Seminar
Research efforts in the Rentschler lab center on defining the transcriptional and epigenetic mechanisms underlying arrhythmias through studying cardiac physiology and regulation of gene expression in murine, porcine and human model systems. Dr. Rentschler’s group has previously demonstrated that reactivation of developmental signaling pathways including Notch and Wnt can electrically remodel cardiomyocytes, or “reprogram” them, to adopt a new electrical phenotype in animal models. In the atria, Notch activation in response to pressure overload regulates a distinct transcriptional signature in the right versus left atrium and may predispose to atrial fibrillation. In contrast, Notch regulates a distinct transcriptional response in adult ventricular cardiomyocytes resulting in reprogramming to a Purkinje-like phenotype. Noninvasive radiation therapy is a novel treatment for ventricular tachycardia, and the lab recently demonstrated that a single high dose of radiation temporarily activates Notch signaling and results in long-term reprogramming of cardiac conduction in normal and diseased hearts. The lab’s work aims to translate insights learned through the study of basic mechanisms of gene expression into novel therapies for arrhythmia.
This is a free event hosted by the Fralin Biomedical Research Institute and the Virginia Tech Carilion School of Medicine. The Timothy A. Johnson Medical Scholar Lecture Series hosts clinician scientists who are exploring frontiers of medicine. These lectures are principally intended for Virginia Tech Carilion School of Medicine students and Virginia Tech students in the Translational Biology, Medicine, and Health graduate program. Virginia Tech and Carilion Clinic faculty, staff, and students may also attend.
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