In Person Seminar: Hippocampal Sharp Wave Sleep: A Unifying View of Sleep in the Hippocampus
Graham Findlay
Doctoral Candidate
Neuroscience Training Program
University of Wisconsin-Madison
In Person Seminar: Hippocampal Sharp Wave Sleep: A Unifying View of Sleep in the Hippocampus
Date: Jan. 31, 2024
Time: 10 a.m.
About this Seminar
It is likely that sleep serves some essential function; if not, it would be hard to understand why humans, and animals in general, spend a significant part of their life engaged in such a costly behavior that is subject to such strong homeostatic regulation. Cortical slow waves are the best understood indicator of sleep need, and their study has led to promising hypotheses about the essential function of sleep. However, comparatively little is known about signatures of sleep need or the impact of sleep loss on the hippocampus, despite the critical role of the hippocampus in many theories of sleep function. By performing continuous 48-hour sleep/wake recordings of cortex and hippocampus in freely moving rats implanted with Neuropixel probes, we characterize the impact of sleep loss on hippocampal circuits, identify hippocampal sharp waves as reliable indicators of hippocampal sleep need, and even find evidence that the hippocampus can sleep somewhat independently of the cortex, during cortical wake. Research by Dr. Findlay and his colleagues suggests that the presence of sharp waves defines a disconnected, homeostatically regulated, and unitary state of the hippocampus, which the researchers call hippocampal sharp wave sleep by analogy to cortical slow wave sleep. Dr. Findlay will discuss why both cortical slow waves and hippocampal sharp waves are such reliable indicators of sleep need, and what this can tell us about the fundamental purpose of sleep.
You May Also Be Interested In...
-
Home ItemMechanics of Convective Cell Motion , home
Jan. 10, 2025, 11:00 a.m. | Michael Murrell, Ph.D., Associate Professor, Department of Biomedical Engineering and Physics, Yale University | Co-Sponsored by the Fralin Biomedical Research Institute Cancer Research Center – Roanoke
-
Home ItemThe Role of Pericytes in Pulmonary Vascular Diseases , home
Jan. 17, 2025, 11:00 a.m. | Vinicio de Jesus Perez, M.D., FCCP, FAHA, Assistant Professor, Wall Center Adult PH Clinic Division of Pulmonary and Critical Care Medicine, Stanford School of Medicine | Co-Sponsored by the Fralin Biomedical Research Institute Center for Vascular and Heart Research
-
Home ItemNeural Circuits for Social Behaviors , home
Jan. 24, 2025, 11:00 a.m. | Marcelo de Oliveira Dietrich, M.D., Ph.D., Associate Professor, Department of Comparative Medicine and Neuroscience, Yale School of Medicine | Co-Sponsored by the Center for Neurobiology Research, Fralin Biomedical Research Institute
-
Home ItemThe Role of Exercise-Induced Blood Factor in Partial Reversal of Age-Related Loss of Plasticity in the Brain , home
Jan. 31, 2025, 11:00 a.m. | Saul Villeda, Ph.D., Associate Professor, Chair, Department of Biomedical Science, University of California, San Francisco | Co-Sponsored by the Center for Exercise Medicine Research, Fralin Biomedical Research Institute
-
Home ItemPsychosocial Adjustment to Disability and Disability Identity Development , home
Feb. 14, 2025, 11:00 a.m. | Anjali Forber-Pratt, Ph.D., Director of Research, American Association on Health and Disability | Co-Sponsored by the Fralin Biomedical Research Institute Center for Human Neuroscience Research
-
Home ItemHow Big Med Drives Rising Healthcare Costs and What to Do About It , home
Feb. 20, 2025, 5:30 p.m. (Reception at 5 p.m.) | Vivian Ho, Ph.D., James A. Baker III Institute Chair in Health Economics, Baker Institute for Public Policy, Rice University | Maury Strauss Distinguished Public Lecture