In Person Seminar: Hippocampal Sharp Wave Sleep: A Unifying View of Sleep in the Hippocampus
Graham Findlay
Doctoral Candidate
Neuroscience Training Program
University of Wisconsin-Madison
In Person Seminar: Hippocampal Sharp Wave Sleep: A Unifying View of Sleep in the Hippocampus
Date: Jan. 31, 2024
Time: 10 a.m.
About this Seminar
It is likely that sleep serves some essential function; if not, it would be hard to understand why humans, and animals in general, spend a significant part of their life engaged in such a costly behavior that is subject to such strong homeostatic regulation. Cortical slow waves are the best understood indicator of sleep need, and their study has led to promising hypotheses about the essential function of sleep. However, comparatively little is known about signatures of sleep need or the impact of sleep loss on the hippocampus, despite the critical role of the hippocampus in many theories of sleep function. By performing continuous 48-hour sleep/wake recordings of cortex and hippocampus in freely moving rats implanted with Neuropixel probes, we characterize the impact of sleep loss on hippocampal circuits, identify hippocampal sharp waves as reliable indicators of hippocampal sleep need, and even find evidence that the hippocampus can sleep somewhat independently of the cortex, during cortical wake. Research by Dr. Findlay and his colleagues suggests that the presence of sharp waves defines a disconnected, homeostatically regulated, and unitary state of the hippocampus, which the researchers call hippocampal sharp wave sleep by analogy to cortical slow wave sleep. Dr. Findlay will discuss why both cortical slow waves and hippocampal sharp waves are such reliable indicators of sleep need, and what this can tell us about the fundamental purpose of sleep.
You May Also Be Interested In...
-
Home ItemSudden Cardiac Arrest in the Young: The case of ARVC , home
Oct. 18, 2024, 11:00 a.m. | Mario Delmar, M.D., Ph.D., Endowed Professor of Medicine, Patricia and Robert Martinsen Professor of Cardiology, Leon H Charney Division of Cardiology, New York University School of Medicine | Co-Sponsored by the Fralin Biomedical Research Institute Center for Vascular and Heart Research
-
Home ItemHarnessing Interoception: Innovative Approaches for Psychiatric Assessment and Intervention , home
Oct. 25, 2024, 11:00 a.m. | Sahib Khalsa, M.D., Ph.D., Associate Professor, Louis Jolyon West Innovation Chair, Director of Anxiety Disorders Research, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles| Co-Sponsored by the Center for Health Behaviors Research and the Addiction Recovery Research Center, Fralin Biomedical Research Institute
-
Home ItemClinical Applications of Cancer Genetics , home
Nov. 21, 2024, 5:30 p.m. (Reception at 5 p.m.) | Luis Diaz, Jr., M.D., Head, Division of Solid Tumor Oncology, Memorial Sloan Kettering Cancer Center; Member, National Academy of Medicine | Maury Strauss Distinguished Public Lecture
-
Home ItemA Ribocentric View of Muscle Proteostasis in Health and Disease: Novel Mechanisms Potential Therapeutic Opportunities , home
Nov. 22, 2024, 11:00 a.m. | Gustavo A. Nader, Ph.D., FAPS, Professor, College of Health and Human Development; Chair, Molecular, Cellular, and Integrative Physiology; Huck Institutes of the Life Sciences; The Pennsylvania State University | Co-Sponsored by the Fralin Biomedical Research Institute Center for Exercise Medicine Research
-
Home ItemHuman Laboratory Evaluation of Cannabis Products , home
Dec. 13, 2024, 11:00 a.m. | Ryan Vandrey, Ph.D., Professor, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine | Co-Sponsored by the Fralin Biomedical Research Institute Center for Health Behaviors Research and the Addiction Recovery Research Center
-
Home ItemMechanics of Convective Cell Motion , home
Jan. 10, 2025, 11:00 a.m. | Michael Murrell, Ph.D., Associate Professor, Department of Biomedical Engineering and Physics, Yale University | Co-Sponsored by the Fralin Biomedical Research Institute Cancer Research Center – Roanoke