Archived Seminar: Understanding the regulation of cardiac contractility by Transient Outward Potassium Channels: How to make an efficient pump
Special Seminar presented by the Center for Vascular and Heart Research and the Fralin Biomedical Research Institute at VTC
Archived Seminar: Understanding the regulation of cardiac contractility by Transient Outward Potassium Channels: How to make an efficient pump
Date: May 19, 2021
Time: 12:00 - 1:00 p.m.
About this Seminar
Dr. Backx will discuss how the timing of the outward currents produced by Transient Outward Potassium (Ito) channels control the timing of calcium release from the Sarcoplasmic Reticulum. This phenomenon leads to the synchronization of contraction across the wall of the ventricle, which is otherwise inherently heterogeneous due to conduction delays from the Purkinje Fibers to the working myocardium. The impact of the Ito Channels on calcium release is mediated by its effects on early repolarization of the action potential (i.e., called Phase 1 or the Cardiac Notch). Changes in early repolarization, in turn, directly control the reverse-mode activity of the Sodium-Calcium Exchanger, thereby driving inward movement of calcium with (energetically efficient) outward sodium movement. Dr. Backx will also discuss work in his lab on cellular mechanisms of atrial fibrillation and the use of cardiomyocytes obtained from patient-derived induced-Pluripotent Stem Cells to understand cardiomyopathies associated with mutations in selected cardiac sodium channels.
You May Also Be Interested In...
-
Home ItemSocial Learning in Borderline Personality Disorder , home
April 4, 2025, 11:00 a.m. | Sarah Fineberg, M.D., Ph.D., Assistant Professor, Department of Psychiatry, Yale School of Medicine | Co-Sponsored by the Fralin Biomedical Research Institute Center for Human Neuroscience Research
-
Home ItemBringing Precision Medicine to Psychiatry , home
April 10, 2025, 5:30 p.m. (Reception at 5 p.m.) | Jordan Smoller, M.D., Sc.D., Massachusetts General Hospital Trustees Endowed Chair in Psychiatric Neuroscience; Professor of Psychiatry, Harvard Medical School; Professor of Epidemiology, T.H. Chan Harvard School of Public Health; Director, Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital | Maury Strauss Distinguished Public Lecture
-
Home ItemExtracellular Vesicles in the Pathogenesis, Diagnosis and Treatment of the Heart , home
April 11, 2025, 11:00 a.m. | Susmita Sahoo, Ph.D., Associate Professor, Department of Medicine and Cardiology, Icahn School of Medicine at Mount Sinai | Co-Sponsored by the Fralin Biomedical Research Institute Center for Vascular and Heart Research
-
Home ItemA Human-Centric View of Cerebellar Development , home
April 18, 2025, 11:00 a.m. | Kathleen Millen, Ph.D., Professor, Department of Pediatrics/Genetics, Associate Director and Principal Investigator, Seattle Children's Hospital Research Institute, The University of Washington School of Medicine | Co-Sponsored by the Center for Neurobiology Research, Fralin Biomedical Research Institute
-
Home ItemMolecular and Neurobiological Studies in Rett Syndrome and Other MECP2 Disorders , home
May 1, 2025, 5:30 p.m. (Reception at 5 p.m.) | Huda Zoghbi, M.D., Professor, Pediatrics, Molecular and Human Genetics, Neuroscience, and Neurology; Director, Jan and Dan Duncan Neurological Research Institute, Baylor College of Medicine; Member, National Academy of Medicine | Maury Strauss Distinguished Public Lecture

Peter Backx, Ph.D., DVM
Professor, Department of Biology, Faculty of Science, York University
Senior Scientist, Division of Cellular and Molecular Medicine and Division of Cardiology, University Health Network, Toronto