Archived Virtual Seminar: IL-1 blockade in heart disease
Special Seminar presented by the Center for Vascular and Heart Research and the Fralin Biomedical Research Institute at VTC
IL-1 blockade in heart disease
Date: May 13, 2021
Time: 11:00 a.m. - 12:00 p.m.
About this Seminar
The intracellular sensing protein termed NLRP3 (for NACHT, LRR, and PYD domains-containing protein 3) forms a macromolecular structure called the NLRP3 inflammasome. The NLRP3 inflammasome plays a major role in inflammation, particular in the production of interleukin-1b (IL-1b). IL-1b is the most studied of the IL-1 family of cytokines, including 11 members among which IL-1a and IL-18. Dr. Abbate will summarize pre-clinical and clinical findings supporting the key pathogenetic role of the NLRP3 inflammasome and IL-1 cytokines in the formation, progression and complications of atherosclerosis, in ischemic (acute myocardial infarction, AMI), and non-ischemic injury to the myocardium (myocarditis) and the progression to heart failure (HF). He will also review the clinically available IL-1 inhibitors, although not currently approved for a cardiovascular indications, and discuss other IL-1 inhibitors, not currently approved, as well as oral NLRP3 inflammasome inhibitors currently in clinical development. Canakinumab, IL‑1b antibody, prevented the recurrence of ischemic events in patients with prior AMI in a large phase III clinical trial including 10,061 patients world-wide. Phase II clinical trials show promising data with anakinra, recombinant IL-1 receptor antagonist, in patients with ST segment elevation AMI or HF with reduced ejection fraction. Anakinra also improved outcomes in patients with pericarditis and it is now considered standard of care as second line treatment for patients with recurrent/refractory pericarditis. Rilonacept, a soluble IL‑1 receptor chimeric fusion protein neutralizing IL-1aand IL-1b, has also shown promising results in a phase II study in recurrent/ refractory pericarditis. In conclusion, there is overwhelming evidence linking the NLRP3 inflammasome and the IL-1 cytokines with the pathogenesis of cardiovascular diseases. The future will likely include targeted inhibitors to block the IL‑1 isoforms, and possibly oral NLRP3 inflammasome inhibitors, across a wide spectrum of cardiovascular diseases.
You May Also Be Interested In...
-
Home ItemBlood-Based Approaches to Counter Aging , home
Jan. 31, 2025, 11:00 a.m. | Saul Villeda, Ph.D., Associate Professor, Chair, Department of Biomedical Science, University of California, San Francisco | Co-Sponsored by the Center for Exercise Medicine Research, Fralin Biomedical Research Institute
-
Home ItemDisability Identity, Inclusivity & Representation in Research , home
Feb. 14, 2025, 11:00 a.m. | Anjali Forber-Pratt, Ph.D., Director of Research, American Association on Health and Disability | Co-Sponsored by the Fralin Biomedical Research Institute Center for Human Neuroscience Research
-
Home ItemHow Big Med Drives Rising Healthcare Costs and What to Do About It , home
Feb. 20, 2025, 5:30 p.m. (Reception at 5 p.m.) | Vivian Ho, Ph.D., James A. Baker III Institute Chair in Health Economics, Baker Institute for Public Policy, Rice University | Maury Strauss Distinguished Public Lecture
-
Home ItemAddictive Nicotine and Stress Induce Convergent Mechanisms That Increase Alcohol Self‐administration , home
Feb. 21, 2025, 11:00 a.m. | John Dani, Ph.D., Professor of Neurological Sciences, Chair, Department of Neuroscience, Scientific Director, UPENN, CNS Consortium, Perlman School of Medicine, University of Pennsylvania | Co-Sponsored by the Fralin Biomedical Research Institute Center for Human Neuroscience Research
-
Home ItemExploring the Functional Role of Gene Variation in Nicotine and Alcohol Abuse , home
Feb. 21, 2025, 1 p.m. | Mariella De Biasi, Ph.D., Professor, Director, Program for Cholingeric Mechanisms in Addiction, Perlman School of Medicine, University of Pennsylvania | Co-Sponsored by the Fralin Biomedical Research Institute Center for Human Neuroscience Research
Antonio Abbate, M.D., Ph.D.
James C. Roberts, Esq., Professor of Cardiology, Department of Internal Medicine, Division of Cardiology, VCU Pauley Heart Center; and Professor, Department of Internal Medicine and Department of Physiology and Biophysics, Virginia Commonwealth University