Special Seminar: Gene Therapy Targeting Vascular Function in Cardiovascular Disease: Are We There Yet?
Steven Fisher, M.D.
Professor
Department of Cardiology and Physiology
University of Maryland - Baltimore
Staff Physician
Baltimore VA Medical Center
Special Seminar: Gene Therapy Targeting Vascular Function in Cardiovascular Disease: Are We There Yet?
Date: May 20, 2022
Time: 11:00 a.m. - 12:00 p.m.
About this Seminar
This past decade has witnessed a renaissance in gene therapies for a broad array of human diseases. Dr. Fisher's talk will focus on mRNA splice variants as targets for gene therapies that by shifting the expression of naturally occurring protein isoforms may have therapeutic benefit. The specific focus is the smooth muscle myosin phosphatase (MP) enzyme, the end effector of vasodilation and key end target of signaling pathways regulating vessel tone and thus blood flow and blood pressure. Our data supports a model in which a splice variant of the MP regulatory subunit Mypt1 sets vascular sensitivity to NO , ANP, and ROS vasodilator signaling. After reviewing this data, Dr. Fisher will present his recent experiments testing the alternative gene therapy approaches of Crispr/Cas9 gene editing and splice-blocking anti-sense oligonucleotides targeting Mypt1 E24. These are potential novel therapies for hypertension and its sequelae HFpEF, the #1 preventable cause of early mortality world-wide.
You May Also Be Interested In...
-
Home Item
In Person Seminar: Win to Fight and Lose to Flight: Innate Yet Flexible Aggression Circuit , homeMarch 24, 2023, 11 a.m. | Dayu Lin, Ph.D., Professor, Department of Psychiatry, Grossman School of Medicine, New York University | Pioneers in Biomedical Research Seminar Series | Co-Sponsored by the Fralin Biomedical Research Institute Center for Neurobiology Research
-
Home Item
Seminar: Signaling and Metabolic Control of Nucleotide Metabolism in Cancer , homeMarch 27, 2023, 11 a.m. | Eunus S. Ali, Ph.D., Postdoctoral Associate, Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University | Seminar
-
Home Item
In Person Seminar: Quantifying Diverse Research Representation , homeMarch 31, 2023, 11:00 a.m. | Jonathan Jackson, Ph.D., Executive Director, Community Access, Recruitment, and Engagement (CARE) Research Center, Harvard University and Massachusetts General Hospital | Pioneers in Biomedical Research Seminar Series | Co-Sponsored by the Fralin Biomedical Research Institute Center for Human Neuroscience Research
-
Home Item
In Person Lecture: Synaptic Injury: A Link to the Past , homeMarch 31, 2023, 1 p.m. | Terrance Kummer, M.D., Ph.D., Associate Professor of Neurology, Washington University School of Medicine in St. Louis | Timothy A. Johnson Medical Scholar Lecture Series
-
Home Item
Seminar: Understanding Cancer: From Development to Therapy , homeApril 5, 2023, 11 a.m. | Biplab Dasgupta, M.S., Ph.D., MBA, Professor of Pediatrics, Division of Oncology, Cincinnati Children's Hospital | Seminar
-
Home Item
In Person Seminar: Brain Dynamics and Flexible Behaviors , homeApril 14, 2023, 11:00 am. | Lucina Q. Uddin, Ph.D., Professor in Residence, Department of Psychiatry and Biobehavioral Science, University of California, Los Angeles | Pioneers in Biomedical Research Seminar Series | Co-Sponsored by the Fralin Biomedical Research Institute Addiction Recovery Research Center and Center for Health Behaviors Research