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Special Seminar: PVC-Induced Cardiomyopathy: The Importance of the Neural Mediator and Therapeutic Implications

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Alex Tan, M.D.

Alex Tan, M.D.

Attending Electrophysiologist
Richmodn Veterans Affairs Medical Center
Associate Professor of Medicine
VCU Health Pauley Heart Center
More About Dr. Tan

PVC-Induced Cardiomyopathy: The Importance of the Neural Mediator and Therapeutic Implications

Date: July 25, 2025

Time:  1 p.m.

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About this Seminar

Arrhythmia-induced cardiomyopathy is a recently defined entity, in which paradoxically, it is the arrhythmia that causes cardiomyopathy (weakening of heart muscle) rather than the more well-established fact that cardiomyopathy causes arrhythmias. In this talk, Dr. Tan will discuss frequent premature ventricular contractions (PVCs) as the arrhythmia that causes cardiomyopathy; and the prevalence and significance of PVC-induced cardiomyopathy, a condition now recognized by ACC/AHA as a major cause of non-ischemic cardiomyopathy, and also discuss how it is may be significantly under-estimated. Dr. Tan will also illuminate how frequent PVCs can induce cardiomyopathy. Specifically, he will focus on how frequent PVCs acutely destabilize the cardiac autonomic nervous system, disrupting the heart’s major mechanism for fine tuning cardiac homeostasis. Next, he will turn to how chronic and PVC exposure remodels the cardiac autonomic nervous system, resetting cardio-neural control to a deleterious state, and the consequences of this adverse neural remodeling. Finally, Dr. Tan will discuss how modulating the cardiac autonomic nervous system in several different ways can interrupt the vicious cycle of PVC-induced neural remodeling, to prevent PVC-induced cardiomyopathy. 

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