In Person Special Seminar: Involvement of Non-canonical Inflammatory Response in Tissue Dysfunction of Several Chronic Diseases

David Crossman, Ph.D.
Academic Director, Biomedical Research Imaging Unit
Senior Research Fellow, Heart Foundation of New Zealand
Cardiac Nanobiology Research Group
Department of Physiology
School of Medical Sciences
Waipapa Taumata Rau | The University of Auckland
In Person Seminar: Fibrosis and Aberrant Ca2+ Handling in the Failing Heart
Date: Feb. 15, 2024
Time: 11 a.m.
About this Seminar
Fibrosis and aberrant Ca2+ handling are hallmarks of heart failure but are considered separate features. However, the fibrotic disposition of nanometer-sized collagen fibrils, particularly collagen VI (ColVI), may directly diminish Ca2+signalling in human heart failure. Using super-resolution microscopy Dr. Crossman and his team found increased ColVI within the transverse(t)-tubules. Moreover, t-tubule remodeling disrupts Ca2+ signaling in heart failure. Recently, circulating levels of ColVI were found to independently associate with poor outcomes in heart failure. While the importance of ColVI to skeletal muscle function is underscored by its mutation causing muscular dystrophy, its role in cardiac contraction remains poorly understood. Significantly, muscular dystrophy patients often develop heart failure. To understand the role of ColVI in the heart the lab created a knockout of this gene in the rat (Col6a1-/-). Echocardiography showed both impaired systolic and diastolic function. Cardiac myocytes from Col6a1-/- have increased systolic Ca2+transient and greater response to b-adrenergic stimulation that is pro-arrhythmogenic. Similar disturbance in Ca2+ handling is found in the cardiac myocytes of the mdx mouse which has non-functional dystrophin supporting our hypothesis that ColVI is part of the dystrophin-glycoprotein-complex and may have a role in regulating Ca2+ dynamics.
You May Also Be Interested In...
-
Home ItemSocial Learning in Borderline Personality Disorder , home
April 4, 2025, 11:00 a.m. | Sarah Fineberg, M.D., Ph.D., Assistant Professor, Department of Psychiatry, Yale School of Medicine | Co-Sponsored by the Fralin Biomedical Research Institute Center for Human Neuroscience Research
-
Home ItemBringing Precision Medicine to Psychiatry , home
April 10, 2025, 5:30 p.m. (Reception at 5 p.m.) | Jordan Smoller, M.D., Sc.D., Massachusetts General Hospital Trustees Endowed Chair in Psychiatric Neuroscience; Professor of Psychiatry, Harvard Medical School; Professor of Epidemiology, T.H. Chan Harvard School of Public Health; Director, Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital | Maury Strauss Distinguished Public Lecture
-
Home ItemExtracellular Vesicles in the Pathogenesis, Diagnosis and Treatment of the Heart , home
April 11, 2025, 11:00 a.m. | Susmita Sahoo, Ph.D., Associate Professor, Department of Medicine and Cardiology, Icahn School of Medicine at Mount Sinai | Co-Sponsored by the Fralin Biomedical Research Institute Center for Vascular and Heart Research
-
Home ItemA Human-Centric View of Cerebellar Development , home
April 18, 2025, 11:00 a.m. | Kathleen Millen, Ph.D., Professor, Department of Pediatrics/Genetics, Associate Director and Principal Investigator, Seattle Children's Hospital Research Institute, The University of Washington School of Medicine | Co-Sponsored by the Center for Neurobiology Research, Fralin Biomedical Research Institute
-
Home ItemMolecular and Neurobiological Studies in Rett Syndrome and Other MECP2 Disorders , home
May 1, 2025, 5:30 p.m. (Reception at 5 p.m.) | Huda Zoghbi, M.D., Professor, Pediatrics, Molecular and Human Genetics, Neuroscience, and Neurology; Director, Jan and Dan Duncan Neurological Research Institute, Baylor College of Medicine; Member, National Academy of Medicine | Maury Strauss Distinguished Public Lecture
-
Home ItemA Novel Bispecific Antibody to Target the Brain Tumor Microenvironment , home
May 2, 2025, 11:00 a.m. | Khuson Yun, Ph.D., Associate Professor, Department of Neurology, Houston Methodist Chair, Neurodegenerative Disease Research, Houston Methodist Research Institute, Weill Cornell Medical College | Co-Sponsored by the Fralin Biomedical Research Institute Cancer Research Center – Roanoke