In Person Special Seminar: Exercise in a Pill: A Chemist Approach and Drugging the S1P Pathway; and a Discussion of the Virginia Tech Center for Drug Discovery
Webster L. Santos, Ph.D.
Professor
Agnes and Cliff Lilly Fellow of Drug Discovery
Department of Chemistry
College of Science
Director, Center for Drug Discover
Virginia Tech
In Person Seminar: Connexin 43: Exercise in a Pill: A Chemist Approach and Drugging the S1P Pathway; and a Discussion of the Virginia Tech Center for Drug Discovery
Date: Feb. 22, 2023
Time: 1 p.m.
About this Seminar
In this presentation, Dr. Santos will highlight his team’s investigations on developing small molecule protonophores selective for mitochondria as potential treatment for obesity and fatty liver disease. The goal is to develop molecules that increase energy expenditure without the need for exercise. On the next part, Dr. Santos will discuss developing inhibitors of proteins in the sphingosine-1-phosphate (S1P) pathway for the treatment of multiple sclerosis and chronic kidney disease. S1P is an endogenous signaling molecule that functions as a chemotactic agent that is important in inflammation, fibrosis, and cancer. In both programs, the medicinal chemistry approach, assay development, and in vivo studies will be presented. Finally, he will discuss the VT Center for Drug Discovery and potential collaborations.
You May Also Be Interested In...
-
Home ItemSeminar: Perceptual Understanding in the Human Brain: From Illusory Faces to Real-world Experience , home
Dec. 16, at 12:30 p.m. | Susan Wardle, Ph.D., Research Fellow, Laboratory of Brain & Cognition, National Institute of Mental Health, National Institutes of Health | Seminar
-
Home ItemSeminar: Germline Predisposition to Clonal Hematopoiesis , home
Dec. 17, at 10:30 a.m. | Sushree Sahoo, Ph.D., Postdoctoral Research Associate, Department of Hematology, St. Jude Children’s Research Hospital | Seminar
-
Home ItemMechanics of Convective Cell Motion , home
Jan. 10, 2025, 11:00 a.m. | Michael Murrell, Ph.D., Associate Professor, Department of Biomedical Engineering and Physics, Yale University | Co-Sponsored by the Fralin Biomedical Research Institute Cancer Research Center – Roanoke
-
Home ItemThe Role of Pericytes in Pulmonary Vascular Diseases , home
Jan. 17, 2025, 11:00 a.m. | Vinicio de Jesus Perez, M.D., FCCP, FAHA, Assistant Professor, Wall Center Adult PH Clinic Division of Pulmonary and Critical Care Medicine, Stanford School of Medicine | Co-Sponsored by the Fralin Biomedical Research Institute Center for Vascular and Heart Research
-
Home ItemNeural Circuits for Social Behaviors , home
Jan. 24, 2025, 11:00 a.m. | Marcelo de Oliveira Dietrich, M.D., Ph.D., Associate Professor, Department of Comparative Medicine and Neuroscience, Yale School of Medicine | Co-Sponsored by the Center for Neurobiology Research, Fralin Biomedical Research Institute
-
Home ItemThe Role of Exercise-Induced Blood Factor in Partial Reversal of Age-Related Loss of Plasticity in the Brain , home
Jan. 31, 2025, 11:00 a.m. | Saul Villeda, Ph.D., Associate Professor, Chair, Department of Biomedical Science, University of California, San Francisco | Co-Sponsored by the Center for Exercise Medicine Research, Fralin Biomedical Research Institute