Archived Seminar: Reprogramming the Brain Cancer Stem Cell
Pioneers in Biomedical Research Seminar presented by the Fralin Biomedical Research Institute at VTC
About This Lecture
Glioblastoma contains subsets of tumor-propagating stem-like cells (i.e. glioma stem cells, GSCs) that are critical determinants of therapeutic resistance and tumor recurrence. GSCs are induced and maintained by dynamic cell reprogramming mechanisms (intra-tumoral induced multipotency) activated by both tumor cell autonomous and paracrine microenvironment-derived signals. Dr. Laterra's talk will describe the molecular basis of these events focusing on the roles of reprogramming transcription factors and downstream miRNA networks that regulate the epigenetic programming of the tumor propagating GSC phenotype.
This is a free event hosted by the Fralin Biomedical Research Institute and co-sponsored by the institute's Cancer Research Group. The Pioneers in Biomedical Research Seminar Series, which runs annually from September to May, has featured leading biomedical researchers from throughout the country since the program began in 2012. Presented virtually via Zoom primarily for research and clinical audiences, the lectures are also open to all members of the Virginia Tech community including graduate students, undergraduates, faculty, and staff, as well as the public.
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John Laterra, M.D., Ph.D.
Professor, Department of Neurology, Department of Neuroscience, and Department of Oncology; Director, Division of Neuro-Oncology, Department of Neurology; Co-Director, Brain Cancer Program, Johns Hopkins Sidney Kimmel Comprehensive Cancer Center; John Hopkins Medicine
Research Scientist, Kennedy Krieger Institute