Archived Seminar: The Fabric of the Neocortex
Pioneers in Biomedical Research Seminar presented by the Fralin Biomedical Research Institute at VTC
The neocortex is responsible for perception, cognition and action. Despite significant advances in our understanding of its structural and functional organization, its underlying computational principles remain largely unknown. The problem lies in understanding how billions of neurons communicating through trillions of synaptic connections orchestrate their activities to give rise to our mental faculties. If there are underlying principles and rules that govern this complexity, then discovering these principles could reduce the impenetrable complexity of the cortex to a manageable scale. One such principle is provided by the hypothesis that the neocortex is composed of repeating circuit motifs that contain numerous cell types wired together according to stereotypical rules which perform canonical computations. Dr. Tolias will describe our findings so far towards our quest to determine what constitutes the elementary computational circuit motif in the neocortex, characterize its structure and function, and decipher its canonical computation(s). First, to define the component cell types we use Patch-seq, a method we developed that combines whole-cell patch-clamp recordings and single-cell RNA sequencing. Patch-seq enables linking molecularly-defined cell types to their corresponding morphological, physiological, and functional phenotypes providing a comprehensive cell types classification scheme. Second, to decipher the principles that govern the connectivity of neocortical circuits we employ multiple whole-cell patching and electron microscopy. Third, to discover the mathematical operations implemented by different cell types and the underlying canonical algorithms of cortical circuit, we use machine-learning including deep learning methods and build models from large scale neural recordings using two- and three-photon imaging.
This is a free event hosted by the Fralin Biomedical Research Institute and co-sponsored by the institute's Center for Neurobiology Research and the Center for Glial Biology in Health, Disease, and Cancer. The Fralin Biomedical Research Institute Pioneers in Biomedical Research Program offers the expertise of a range of scientists who are exploring frontiers in biomedical research. These seminars are open to Virginia Tech and Carilion Clinic faculty, students, and staff.
You May Also Be Interested In...
Home ItemVirtual Seminar: Limb Salvage: An Ideal Role of a Bioengineer in Medicine and Surgery , home
Sept. 17, 2021, 3:00 p.m. | Edmund Y.S. Chao, Ph.D. | Seminar
Home ItemVirtual Seminar: Src Inhibitory Peptides Based on Connexin43 as a Promising Therapy Against Glioblastoma , home
Oct. 1, 2021, 11:00 a.m. | Arantxa Tabernero, Ph.D. | Pioneers in Biomedical Research Seminar Series
Home ItemIn Person Seminar: When Your Heart Skips More Than a Beat: Connexin Hemichannels in Cardiac Pathology , home
Oct. 8, 2021, 11:00 a.m. | Jorge Contreras, Ph.D. | Pioneers in Biomedical Research Seminar Series
Home ItemVirtual Public Lecture: Digital Innovations Are Essential For Leading Organizations: A Houston Methodist Hospital Experience , home
Oct. 14, 2021 5:30 p.m. | Roberta L. Schwartz, Ph.D. | Maury Strauss Distinguished Public Lecture | Dr. Schwartz is an elected fellow of the American Academy of Healthcare Executives
Home ItemVirtual Seminar: Dopamine Circuits in Reward and Aversion , home
Oct. 15, 2021, 11:00 a.m. | Stephan Lammel, Ph.D. | Pioneers in Biomedical Research Seminar Series
Andreas Tolias, Ph.D.
Professor and Brown Foundation Endowed Chair of Neuroscience, Founder and Director of the Center for Neuroscience and Artificial Intelligence, Department of Neuroscience, Baylor College of Medicine