Archived Seminar: Parkinson's Disease and Why Development Matters
Pioneers in Biomedical Research Seminar presented by the Fralin Biomedical Research Institute at VTC
Parkinson’s Disease (PD) is defined clinically by motor symptoms that usually arise late in life and are the result of the loss of dopaminergic neurons, but a variety of nonmotor symptom including depression can precede these symptoms by many years, and genes causing PD are normally expressed throughout the lifespan, including development. It is with this in mind, that we have been examining the effect of PD-causing gene mutations on brain development. Our data show that a knockin mutation of the most prevalent genetic cause of PD, LRRK2-G2019S, alters the structure and function of corticostriatal circuits, and suggest that LRRK2-G2019S coopts synaptic circuits early in life, biasing the actions of cellular pathways in ways that have enduring consequences for learning and stress-related responses in young adulthood. The changes we observe serve to outline novel pathways that can be used to understand, detect, or treat PD.
This is a free event hosted by the Fralin Biomedical Research Institute and co-sponsored by the institute's Center for Neurobiology Research and the Center for Glial Biology in Health, Disease, and Cancer. The Fralin Biomedical Research Institute Pioneers in Biomedical Research Program offers the expertise of a range of scientists who are exploring frontiers in biomedical research. These seminars are open to Virginia Tech and Carilion Clinic faculty, students, and staff.
You May Also Be Interested In...
Home ItemVirtual Seminar: Limb Salvage: An Ideal Role of a Bioengineer in Medicine and Surgery , home
Sept. 17, 2021, 3:00 p.m. | Edmund Y.S. Chao, Ph.D. | Seminar
Home ItemVirtual Seminar: Src Inhibitory Peptides Based on Connexin43 as a Promising Therapy Against Glioblastoma , home
Oct. 1, 2021, 11:00 a.m. | Arantxa Tabernero, Ph.D. | Pioneers in Biomedical Research Seminar Series
Home ItemIn Person Seminar: When Your Heart Skips More Than a Beat: Connexin Hemichannels in Cardiac Pathology , home
Oct. 8, 2021, 11:00 a.m. | Jorge Contreras, Ph.D. | Pioneers in Biomedical Research Seminar Series
Home ItemVirtual Public Lecture: Digital Innovations Are Essential For Leading Organizations: A Houston Methodist Hospital Experience , home
Oct. 14, 2021 5:30 p.m. | Roberta L. Schwartz, Ph.D. | Maury Strauss Distinguished Public Lecture | Dr. Schwartz is an elected fellow of the American Academy of Healthcare Executives
Home ItemVirtual Seminar: Dopamine Circuits in Reward and Aversion , home
Oct. 15, 2021, 11:00 a.m. | Stephan Lammel, Ph.D. | Pioneers in Biomedical Research Seminar Series
Deanna Benson, Ph.D.
Professor in the Nash Family Department of Neuroscience and the Friedman Brain Institute at the Icahn School of Medicine at Mount Sinai