Archived Seminar: Parkinson's Disease and Why Development Matters
Pioneers in Biomedical Research Seminar presented by the Fralin Biomedical Research Institute at VTC
Archived Seminar: Parkinson's Disease and Why Development Matters
Date: Sept. 25, 2020
Time: 11:00 a.m. - 12:00 p.m.
Parkinson’s Disease (PD) is defined clinically by motor symptoms that usually arise late in life and are the result of the loss of dopaminergic neurons, but a variety of nonmotor symptom including depression can precede these symptoms by many years, and genes causing PD are normally expressed throughout the lifespan, including development. It is with this in mind, that we have been examining the effect of PD-causing gene mutations on brain development. Our data show that a knockin mutation of the most prevalent genetic cause of PD, LRRK2-G2019S, alters the structure and function of corticostriatal circuits, and suggest that LRRK2-G2019S coopts synaptic circuits early in life, biasing the actions of cellular pathways in ways that have enduring consequences for learning and stress-related responses in young adulthood. The changes we observe serve to outline novel pathways that can be used to understand, detect, or treat PD.
Additional Details
This is a free event hosted by the Fralin Biomedical Research Institute and co-sponsored by the institute's Center for Neurobiology Research and the Center for Glial Biology in Health, Disease, and Cancer. The Fralin Biomedical Research Institute Pioneers in Biomedical Research Program offers the expertise of a range of scientists who are exploring frontiers in biomedical research. These seminars are open to Virginia Tech and Carilion Clinic faculty, students, and staff.
You May Also Be Interested In...
-
Home Item
Social Learning in Borderline Personality Disorder , homeApril 4, 2025, 11:00 a.m. | Sarah Fineberg, M.D., Ph.D., Assistant Professor, Department of Psychiatry, Yale School of Medicine | Co-Sponsored by the Fralin Biomedical Research Institute Center for Human Neuroscience Research
-
Home Item
Bringing Precision Medicine to Psychiatry , homeApril 10, 2025, 5:30 p.m. (Reception at 5 p.m.) | Jordan Smoller, M.D., Sc.D., MGH Trustees Endowed Chair in Psychiatric Neuroscience; Professor of Psychiatry, Harvard Medical School; Professor of Epidemiology, T.H. Chan Harvard School of Public Health; Director, Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital | Maury Strauss Distinguished Public Lecture
-
Home Item
Extracellular Vesicles in the Pathogenesis, Diagnosis and Treatment of the Heart , homeApril 11, 2025, 11:00 a.m. | Susmita Sahoo, Ph.D., Associate Professor, Department of Medicine and Cardiology, Icahn School of Medicine at Mount Sinai | Co-Sponsored by the Fralin Biomedical Research Institute Center for Vascular and Heart Research
-
Home Item
A Human-Centric View of Cerebellar Development , homeApril 18, 2025, 11:00 a.m. | Kathleen Millen, Ph.D., Professor, Department of Pediatrics/Genetics, Associate Director and Principal Investigator, Seattle Children's Hospital Research Institute, The University of Washington School of Medicine | Co-Sponsored by the Center for Neurobiology Research, Fralin Biomedical Research Institute
-
Home Item
Molecular and Neurobiological Studies in Rett Syndrome and Other MECP2 Disorders , homeMay 1, 2025, 5:30 p.m. (Reception at 5 p.m.) | Huda Zoghbi, M.D., Professor, Pediatrics, Molecular and Human Genetics, Neuroscience, and Neurology; Director, Jan and Dan Duncan Neurological Research Institute, Baylor College of Medicine; Member, National Academy of Medicine | Maury Strauss Distinguished Public Lecture
Deanna Benson, Ph.D.
Professor in the Nash Family Department of Neuroscience and the Friedman Brain Institute at the Icahn School of Medicine at Mount Sinai