Opposing Activities of Chromatin Modifiers in Balancing Stem Cell Division, Differentiation, and Death
Jamy Peng, Ph.D.
Department of Developmental Neurobiology
Comprehensive Cancer Care Center
St. Jude Children's Research Hospital
Pioneers in Biomedical Research Seminar: Opposing Activities of Chromatin Modifiers in Balancing Stem Cell Division, Differentiation, and Death
About this Seminar
Neural stem cell division, neurogenesis, and gliogenesis give rise to all cells in the brain. Dr. Peng's lab studies the modifiers of histone H3 lysine 27 (H3K27), which regulate genetic programs for neural stem cell amplification and differentiation. Dysfunction in H3K27 modifiers lead to developmental disorders and pediatric brain tumors. The lab has uncovered regulators of these H3K27 modifiers that control stem cell division, differentiation, and death. These advances illuminate epigenetic regulation of neural stem cells and pathogenic mechanisms in brain defects and malignancy.
This is a free event hosted by the Fralin Biomedical Research Institute and co-sponsored by the institute's Cancer Research Group. The Pioneers in Biomedical Research Seminar Series, which runs annually from September to May, has featured leading biomedical researchers from throughout the country since the program began in 2012. The lectures are also open to all members of the Virginia Tech community including graduate students, undergraduates, faculty, and staff, as well as the public.
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