Regulation of Endothelial Cell Specialization
Karen K. Hirschi, Ph.D.
Director, Developmental Genomics Center
Professor, Department of Cell Biology
University of Virginia
In Person Pioneers in Biomedical Research Seminar: Regulation of Endothelial Cell Specialization
Date: Sept. 16, 2022
Time: 11 a.m. - 12 p.m.
Location: Fralin Biomedical Research Institute at VTC, Room G101A/B, 4 Riverside Circle, Roanoke, Virginia
Virtual attendance: Join via Zoom.
About this Seminar
During the process of blood vessel development, primordial endothelial cells are formed and become specified toward arterial or venous fates to generate a circulatory network that provides nutrients and oxygen to, and removes metabolic waste from, all tissues. Specification of arterial and venous endothelial cells occurs in conjunction with suppression of endothelial cell cycle progression, and endothelial cell hyperproliferation is associated with potentially lethal arterial-venous malformations. However, the mechanistic role that cell cycle state plays in arterial-venous specification has been unknown. Dr. Hirschi’s studies demonstrate that endothelial cell cycle control plays a key role in arterial-venous network formation, and distinct cell cycle states provide distinct windows of opportunity for the molecular induction of arterial vs. venous specification. This work has broad implications for vascular tissue engineering and regenerative medicine, as well as the treatment of vascular disorders.
Additional Details
This is a free event hosted by the Fralin Biomedical Research Institute and co-sponsored by the institute's Center for Vascular and Heart Research. The Pioneers in Biomedical Research Seminar Series, which runs annually from September to May, has featured leading biomedical researchers from throughout the country since the program began in 2012. The lectures are also open to all members of the Virginia Tech community including graduate students, undergraduates, faculty, and staff, as well as the public.
You May Also Be Interested In...
-
Home ItemInter-Organelle Communication Pathways and Dynamics Revealed by Imaging , home
Sept. 9, 2022, 11 a.m. | Jennifer Lippincott-Schwartz, Ph.D., Senior Group Leader, Howard Hughes Medical Institute, Janelia Research Campus | Pioneers in Biomedical Research Seminar Series | Co-Sponsored by the Fralin Biomedical Research Institute Center for Neurobiology Research
-
Home ItemRegulation of Endothelial Cell Specialization , home
Sept. 16, 2022, 11 a.m. | Karen K. Hirschi, Ph.D., Professor and Director, Developmental Genomics Center, University of Virginia | Pioneers in Biomedical Research Seminar Series | Co-Sponsored by the Fralin Biomedical Research Institute Center for Vascular and Heart Research
-
Home ItemAlbinism: Can It Become a Treatable Disease? , home
Sept. 16, 2022, 1 p.m. | Brian Brooks, M.D., Ph.D., Senior Investigator, National Eye Institute, National Institutes of Health | Timothy A. Johnson Medical Scholar Lecture Series
-
Home ItemSocially-Directed Science and Technology: Design at the Intersection of History, Sustainability, and Equity with Applications to Biotechnology and Biomaterials , home
Sept. 22, 2022, 5:30 p.m. (Reception at 5 p.m.) | Christine Ortiz, Ph.D., Morris Cohen Professor of Materials Science and Engineering, Massachusetts Institute of Technology | Maury Strauss Distinguished Public Lecture
-
Home ItemConnectomics of Addiction Recovery , home
Sept. 23, 2022, 11:00 am. | Sarah Yip, Ph.D., Associate Professor of Child Study, Yale School of Medicine | Pioneers in Biomedical Research Seminar Series | Co-Sponsored by the Fralin Biomedical Research Institute Addiction Recovery Research Center and Center for Health Behaviors Research
-
Home ItemTitle TBD , home
Sept. 23, 2022, 1 p.m. | Shahid Nimjee, M.D., Ph.D., Associate Professor of Neurological Surgery, The Ohio State University | Timothy A. Johnson Medical Scholar Lecture Series