In Person Seminar: Deciphering the Metabolic Origins of Heart Failure: Towards Novel Therapeutic Targets
Daniel Kelly, Ph.D.
Willard and Rhoda Ware Professor
Director
Penn and CHOP Cardiovascular Institutes
Perelman School of Medicine
University of Pennsylvania
Children's Hospital of Philadelphia
Pioneers in Biomedical Research Seminar: Deciphering the Metabolic Origins of Heart Failure: Towards Novel Therapeutic Targets
Date: March 22, 2024
Time: 11 a.m. - 12 p.m.
About this Seminar
During the development of heart failure, the myocardium undergoes fuel metabolic reprogramming that reduces the capacity for ATP production. This ultimately leads to an “energy starvation” that contributes to the pathogenesis of heart failure. The Kelly Lab has delineated the transcriptional regulatory circuitry that controls mitochondria function and fuel oxidation in the developing heart. In addition, metabolomic and proteomic profiling has identified nodal points for re-balancing the metabolic derangements of the failing heart. Dr. Kelly’s presentation will cover these topics.
Additional Details
This is a free event hosted by the Fralin Biomedical Research Institute and co-sponsored by the institute's Center for Vascular and Heart Research. The Pioneers in Biomedical Research Seminar Series, which runs annually from September to May, has featured leading biomedical researchers from throughout the country since the program began in 2012. The lectures are also open to all members of the Virginia Tech community including graduate students, undergraduates, faculty, and staff, as well as the public.
You May Also Be Interested In...
-
Home Item
Addictive Nicotine and Stress Induce Convergent Mechanisms That Increase Alcohol Self‐administration , homeFeb. 21, 2025, 11:00 a.m. | John Dani, Ph.D., Professor of Neurological Sciences, Chair, Department of Neuroscience, Scientific Director, UPENN, CNS Consortium, Perlman School of Medicine, University of Pennsylvania | Co-Sponsored by the Fralin Biomedical Research Institute Center for Human Neuroscience Research
-
Home Item
Exploring the Functional Role of Gene Variation in Nicotine and Alcohol Abuse , homeFeb. 21, 2025, 1 p.m. | Mariella De Biasi, Ph.D., Professor, Director, Program for Cholingeric Mechanisms in Addiction, Perlman School of Medicine, University of Pennsylvania | Co-Sponsored by the Fralin Biomedical Research Institute Center for Human Neuroscience Research
-
Home Item
The Relationship between Mitochondrial Function and Heart Failure , homeFeb. 28, 2025, 11:00 a.m. | Rong Tian, M.D., Ph.D., Professor, Department of Anesthesiology and Bioengineering, University of Washington | Co-Sponsored by the Fralin Biomedical Research Institute Center for Vascular and Heart Research
-
Home Item
Suicide by Firearm in the United States: A Collaborative Path for Prevention , homeMarch 6, 2025, 5:30 p.m. (Reception at 5 p.m.) | Marian Betz, M.D., M.P.H. Professor, Departments of Epidemiology and Emergency Medicine, Deputy Director, Injury & Violence Prevention Center, University of Colorado School of Public Health; Member, National Academy of Medicine | Maury Strauss Distinguished Public Lecture
-
Home Item
Thinking the Right Thoughts , homeMarch 7, 2025, 11:00 a.m. | Nathaniel Daw, Ph.D., Professor, Computational and Theoretical Neuroscience, Department of Psychology, Princeton University | Co-Sponsored by the Fralin Biomedical Research Institute Center for Human Neuroscience Research
-
Home Item
The Emergence of Network Activity Patterns - An Early Window to Autism Spectrum Disorder , homeMarch 14, 2025, 11:00 a.m. | Natalia De Marco Garcia, Ph.D., Associate Professor, Department of Neuroscience, The Brain and Mind Research Institute, Weill Cornell Medical College | Co-Sponsored by the Center for Neurobiology Research, Fralin Biomedical Research Institute