Chemistry of the Adaptive Mind

The human brain faces a variety of computational tradeoffs, such as the flexibility/stability tradeoff. In this lecture, Dr. Cools will argue that the major ascending neuromodulatory systems originating from the midbrain are well suited to dynamically regulate these computational tradeoffs depending on our constantly changing task demands. Her working hypothesis follows from a number of general principles of chemical neuromodulation, which she will illustrate by reviewing evidence from recent pharmacological PET/fMRI studies on (cost/benefit decision making about) cognitive control. These studies also begin to elucidate the mechanisms underlying the huge variability in catecholaminergic drug effects across different individuals and behaviours.

Additional Details 

This is a free event hosted by the Fralin Biomedical Research Institute and co-sponsored by the institute's Center for Human Neuroscience Research. The Fralin Biomedical Research Institute Pioneers in Biomedical Research Program offers the expertise of a range of scientists who are exploring frontiers in biomedical research. These seminars are open to Virginia Tech and Carilion Clinic faculty, students, and staff.

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