Archived Seminar: Chemistry of the Adaptive Mind
Pioneers in Biomedical Research Seminar presented by the Fralin Biomedical Research Institute at VTC
About This Lecture
The human brain faces a variety of computational tradeoffs, such as the flexibility/stability tradeoff. In this lecture, Dr. Cools will argue that the major ascending neuromodulatory systems originating from the midbrain are well suited to dynamically regulate these computational tradeoffs depending on our constantly changing task demands. Her working hypothesis follows from a number of general principles of chemical neuromodulation, which she will illustrate by reviewing evidence from recent pharmacological PET/fMRI studies on (cost/benefit decision making about) cognitive control. These studies also begin to elucidate the mechanisms underlying the huge variability in catecholaminergic drug effects across different individuals and behaviours.
This is a free event hosted by the Fralin Biomedical Research Institute and co-sponsored by the institute's Center for Human Neuroscience Research. The Pioneers in Biomedical Research Seminar Series, which runs annually from September to May, has featured leading biomedical researchers from throughout the country since the program began in 2012. Presented virtually via Zoom primarily for research and clinical audiences, the lectures are also open to all members of the Virginia Tech community including graduate students, undergraduates, faculty, and staff, as well as the public.
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Roshan Cools, Ph.D.
Professor; Chair of Cognitive Neuropsychiatry, Department of Psychiatry, Radboud University Nijmegan Medical Centre; Principal Investigator, Donders Institute for Brain, Cognition and Behavior, Radboud University