Archived Seminar: Design and Optimization of CAR T cells and their Application to Glioblastoma
Pioneers in Biomedical Research Seminar presented by the Fralin Biomedical Research Institute at VTC
Archived Seminar: Design and Optimization of CAR T Cells and Their Application to Glioblastoma
Date: Sept. 18, 2020
Time: 11:00 a.m. - 12:00 p.m.
Abstract
Encouraging clinical experience with chimeric antigen receptor (CAR) T cells supports the notion that even immune privileged sites such as the brain may be amenable to CAR therapy. In the context of hematologic B-cell malignancies, CD19-CARs have been shown to accumulate in the cerebrospinal fluid (CSF) and reduce the incidence of metastatic disease in the central nervous system. However, brain tumors pose significant challenges for CAR T cell therapy, including heterogeneous antigen expression, immunosuppressive networks in the tumor microenvironment that limit CAR T cell function and persistence, and suboptimal T cell trafficking to the tumor site. This presentation will describe our clinical experience with CAR T cells for glioblastoma (GBM), one of the most common and aggressive primary malignant brain tumors, and our efforts to overcome therapeutic challenges.
Additional Details
This is a free event hosted by the Fralin Biomedical Research Institute and co-sponsored by the institute's Cancer Research Group. The Fralin Biomedical Research Institute Pioneers in Biomedical Research Program offers the expertise of a range of scientists who are exploring frontiers in biomedical research. These seminars are open to Virginia Tech and Carilion Clinic faculty, students, and staff.
You May Also Be Interested In...
-
Home ItemUnderstanding the Limits of Exercise Responsiveness in Older Adults , home
Sept. 20, 2024, 11:00 a.m. | Ian R. Lanza, Ph.D., Professor of Medicine, Mayo Clinic College of Medicine and Science | Co-Sponsored by the Center for Exercise Medicine Research, Fralin Biomedical Research Institute
-
Home ItemFrom Variant Functionality to Resistance in Cancer , home
Sept. 27, 2024, 11:00 a.m. | Tiki Hayes, Ph.D., Assistant Professor, Department of Molecular and Medical Pharmacology, UCLA David Geffen School of Medicine | Co-Sponsored by the Fralin Biomedical Research Institute Cancer Research Center – D.C.
-
Home ItemDisrupting Health Care Using Deep Data and Remote Monitoring , home
Oct. 4, 2024, 11:00 a.m. | Michael Snyder, Ph.D., Professor, Genetics, Director, Center for Genomics and Personalized Medicine, Stanford Medicine | Co-Sponsored by the Fralin Biomedical Research Institute Center for Exercise Medicine Research
-
Home ItemMechanisms of Longevity: From Mice to Whales , home
Oct. 10, 2024, 5:30 p.m. (Reception at 5 p.m.) | Vera Gorbunova, Ph.D., Doris Johns Cherry Professor of Biology, Co-director, Rochester Aging Research Center, University of Rochester | Maury Strauss Distinguished Public Lecture
-
Home ItemContinuous Decision-Making , home
Oct. 11, 2024, 11:00 a.m. | Benjamin Hayden, Ph.D., Professor and McNair Scholar of Neurosurgery, Baylor College of Medicine | Co-Sponsored by the Fralin Biomedical Research Institute Center for Human Neuroscience Research
Christine Brown, Ph.D.
Professor in the Department of Hematology and Hematopoietic Cell Transplantation; Heritage Provider Network Professor in Immunotherapy; and Deputy Director of the T Cell Therapeutics Research Laboratory, at City of Hope