Virginia Tech® home

Archived Seminar: Design and Optimization of CAR T cells and their Application to Glioblastoma

Pioneers in Biomedical Research Seminar presented by the Fralin Biomedical Research Institute at VTC

Archived Seminar: Design and Optimization of CAR T Cells and Their Application to Glioblastoma

Date: Sept. 18, 2020
Time: 11:00 a.m. - 12:00 p.m.

Abstract

Encouraging clinical experience with chimeric antigen receptor (CAR) T cells supports the notion that even immune privileged sites such as the brain may be amenable to CAR therapy. In the context of hematologic B-cell malignancies, CD19-CARs have been shown to accumulate in the cerebrospinal fluid (CSF) and reduce the incidence of metastatic disease in the central nervous system. However, brain tumors pose significant challenges for CAR T cell therapy, including heterogeneous antigen expression, immunosuppressive networks in the tumor microenvironment that limit CAR T cell function and persistence, and suboptimal T cell trafficking to the tumor site. This presentation will describe our clinical experience with CAR T cells for glioblastoma (GBM), one of the most common and aggressive primary malignant brain tumors, and our efforts to overcome therapeutic challenges.

Additional Details 

This is a free event hosted by the Fralin Biomedical Research Institute and co-sponsored by the institute's Cancer Research Group. The Fralin Biomedical Research Institute Pioneers in Biomedical Research Program offers the expertise of a range of scientists who are exploring frontiers in biomedical research. These seminars are open to Virginia Tech and Carilion Clinic faculty, students, and staff.

 

You May Also Be Interested In...

  • Home Item
    Inheriting Chromatin Domains in Mammals and the Mechanisms Involved , home

    Sept. 5, 2025, 11:00 a.m. | Thelma Escobar, Ph.D., Assistant Professor, Department of Biochemistry, Institute for Stem Cell & Regenerative Medicine, University of Washington | Co-Sponsored by the Fralin Biomedical Research Institute and Cancer Research Center — D.C.

  • Home Item
    Flow Induced Endothelial Planar Polarity for Signaling Regulation , home

    Sept. 19, 2025, 11:00 a.m. | Julia Mack, Ph.D., Assistant Adjunct Professor, David Geffen School of Medicine, Division of Cardiology, University of California Los Angeles | Co-Sponsored by the Fralin Biomedical Research Institute Center for Vascular and Heart Research

  • Home Item
    The Bitter Truth: Alcohol Use and Its Effects on Chemosensory Function , home

    Oct. 3, 2025, 11:00 a.m. | Paule Valery Joseph, Ph.D., Lasker Clinical Research Scholar, NIH Distinguished Scholar; Acting Chief, Section of Sensory Science and Metabolism Unit, Co-Director of the National Smell and Taste Center, National Institute on Deafness and Other Communication Disorders; National Institute of Alcohol Abuse and Alcoholism, National Institutes of Health | Co-Sponsored by the Fralin Biomedical Research Institute Center for Health Behaviors Research and Addiction Recovery Research Center

  • Home Item
    Organization and Control of Hippocampal Networks , home

    Oct. 17, 2025, 11:00 a.m. | Ivan Soltesz, Ph.D., James R. Doty Professor of Neurosurgery and Neurosciences, Stanford University | Co-Sponsored by the Fralin Biomedical Research Institute Center for Neurobiology Research

  • Home Item
    Thinking the Right Thoughts , home

    Oct. 31, 2025, 11 a.m. | Nathaniel Daw, Ph.D., Professor, Computational and Theoretical Neuroscience, Department of Psychology, Princeton University | Co-Sponsored by the Fralin Biomedical Research Institute Center for Human Neuroscience Research

Christine Brown, Ph.D. to present at Fralin Biomedical Research Institute

Christine Brown, Ph.D. 

Professor in the Department of Hematology and Hematopoietic Cell Transplantation; Heritage Provider Network Professor in Immunotherapy; and Deputy Director of the T Cell Therapeutics Research Laboratory, at City of Hope